[en] Objective: To investigate cerebral structure in Tourette's syndrome (TS). Methods: Voxel-based morphometry study of high-resolution MRIs in 31 TS patients compared with 31 controls. Results: Increased gray matter mainly in the left mesencephalon in 31 TS patients. Interpretation: This result constitutes strong and direct evidence supporting Devinsky's hypothesis (Devinsky O. Neuroanatomy of Gilles de la Tourette's syndrome. Possible midbrain involvement. Arch Neurol 1983;40:508514) according to which midbrain disturbances play an important pathogenic role in TS.
Disciplines :
Neurology Radiology, nuclear medicine & imaging
Author, co-author :
Garraux, Gaëtan ; Université de Liège - ULiège > Centre de Recherches du Cyclotron et Département des sciences cliniques > Neurologie
Goldfine, Andrew; Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
Bohlhalter, Stephan; Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
Lerner, Alicia; Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
Hanakawa, Takashi; Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
Hallett, Mark; Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
Language :
English
Title :
Increased midbrain gray matter in Tourette's syndrome
Publication date :
February 2006
Journal title :
Annals of Neurology
ISSN :
0364-5134
eISSN :
1531-8249
Publisher :
Wiley Liss, Inc., Hoboken, United States - New Jersey
NINDS - National Institute of Neurological Disorders and Stroke F.R.S.-FNRS - Fonds de la Recherche Scientifique Horlait-Dapsens Foundations Fondation Léon Fredericq BAEF - Belgian American Educational Foundation
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