Article (Scientific journals)
Increased midbrain gray matter in Tourette's syndrome
Garraux, Gaëtan; Goldfine, Andrew; Bohlhalter, Stephan et al.
2006In Annals of Neurology, 59 (2), p. 381-385
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Keywords :
Tourette syndrome; MRI; gray matter
Abstract :
[en] Objective: To investigate cerebral structure in Tourette's syndrome (TS). Methods: Voxel-based morphometry study of high-resolution MRIs in 31 TS patients compared with 31 controls. Results: Increased gray matter mainly in the left mesencephalon in 31 TS patients. Interpretation: This result constitutes strong and direct evidence supporting Devinsky's hypothesis (Devinsky O. Neuroanatomy of Gilles de la Tourette's syndrome. Possible midbrain involvement. Arch Neurol 1983;40:508514) according to which midbrain disturbances play an important pathogenic role in TS.
Disciplines :
Neurology
Radiology, nuclear medicine & imaging
Author, co-author :
Garraux, Gaëtan  ;  Université de Liège - ULiège > Centre de Recherches du Cyclotron et Département des sciences cliniques > Neurologie
Goldfine, Andrew;  Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
Bohlhalter, Stephan;  Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
Lerner, Alicia;  Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
Hanakawa, Takashi;  Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
Hallett, Mark;  Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
Language :
English
Title :
Increased midbrain gray matter in Tourette's syndrome
Publication date :
February 2006
Journal title :
Annals of Neurology
ISSN :
0364-5134
eISSN :
1531-8249
Publisher :
Wiley Liss, Inc., Hoboken, United States - New Jersey
Volume :
59
Issue :
2
Pages :
381-385
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
NINDS - National Institute of Neurological Disorders and Stroke [US-MD] [US-MD]
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Horlait-Dapsens Foundations [BE]
Fondation Léon Fredericq [BE]
BAEF - Belgian American Educational Foundation [BE]
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