dementia; Alzheimer; cerebral activity; démence sénile; PET
Abstract :
[en] Different scales can be used to evaluate dementia severity in Alzheimers disease (AD). They do assess different cognitive or functional abilities, but their global scores are frequently in mutual correlation. Functional imaging provides an objective method for the staging of dementia severity. Positron emission tomography was used to assess the relationship between brain metabolism and four dementia scales that reflect a patients global cognitive abilities (mini mental state), caregivers evaluation of cognitive impairment (newly designed scale), daily living functioning (instrumental activities of daily living) and global dementia (clinical dementia rating). We wondered whether different clinical dementia scales would be related to severity of metabolic impairment in the same brain regions, and might reflect impairment of common cognitive processes. 225 patients with probable AD were recruited in a prospective multicentre European study. All clinical scales were related to brain metabolism in associative temporal, parietal or frontal areas. A factorial analysis demonstrated that all scales could be classified in a single factor. That factor was highly correlated to decrease of cerebral activity in bilateral parietal and temporal cortices, precuneus, and left middle frontal gyrus. This finding suggests that global scores for all scales provided similar information on the neural substrate of dementia severity. Capitalizing on the neuroimaging literature, dementia severity reflected by reduced metabolism in posterior and frontal associative areas in AD might be related to a decrease of controlled processes.
Research Center/Unit :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Disciplines :
Radiology, nuclear medicine & imaging Neurology
Author, co-author :
Salmon, Eric ; Université de Liège - ULiège > Centre de Recherches du Cyclotron et Département des sciences cliniques > Neurologie
Lespagnard, Solange ; Université de Liège - ULiège > Département des sciences cognitives > Neuropsychologie
Marique, Patricia; Université de Liège - ULiège > Departement des Sciences cognitives > Neuropsychologie
Peeters, F.; Université de Liège - ULiège > Departement des Sciences cognitives > Neuropsychologie
Herholz, Karl; Department of Neurology & Max-Planck Institute for Neurological Research, University Cologne, Cologne
Perani, Daniela; Vita Salute San Raffaele University, Via Olgenttina 60, 20132 Milan, Italy
Holthoff, Vera; Department of Psychiatry and Psychotherapy, Dresden University of Technology, Fletscherstr 74, 01307 Dresden, Germany
Kalbe, E.; Department of Neurology & Max-Planck Institute for Neurological Research, University Cologne, Cologne
Anchisi, D.; Vita Salute San Raffaele University, Via Olgenttina 60, 20132 Milan, Italy
Adam, Stéphane ; Université de Liège - ULiège > Département des sciences cognitives > Département des sciences cognitives
Collette, Fabienne ; Université de Liège - ULiège > Département des sciences cognitives > Neuropsychologie
Garraux, Gaëtan ; Université de Liège - ULiège > Centre de Recherches du Cyclotron et Département des sciences cliniques > Neurologie
Language :
English
Title :
Cerebral metabolic correlates of four dementia scales in Alzheimer's disease
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