Cerebral blood flow; Arterial spin labeling; fMRI; Motor system; Deactivation
Abstract :
[en] Arterial spin labeling (ASL) perfusion functional magnetic resonance imaging (fMRI) is an attractive alternative to BOLD fMRI. Nevertheless, current ASL fMRI techniques are limited by several factors that hamper more routine applications in humans. One of these factors is restricted brain coverage so that whole-brain ASL fMRI studies have never been reported. The present study tested the ability of a multislice continuous ASL (CASL) fMRI approach using a small surface coil placed on the subject's neck to map changes in regional cerebral blood flow (rCBF) throughout the brain while healthy individuals (N = 15) performed memory-guided sequential finger movements at a mean rate of similar to0.5 Hz. As predicted by results from a large number of studies, reliable task-related increases in flow were detected across subjects not only in primary and associative cortical areas but also in subcortical brain regions. When normalized to baseline, rCBF increased 31% in the hand representation area (HRA) of left primary motor cortex (M1) 13% in the left supplementary motor area proper (SMA), 10% in the left dorsolateral prefrontal cortex (DLPFC), 10-18% in the bilateral intraparietal sulci, 6% in the HRA of left putamen, 10% in the left thalamus, and 17% in the right anterior cerebellum. In addition to these increases, 6% and 4% decreases in rCBF were detected in the HRA of the right M1 and the bilateral posterior cingulate sulci, respectively. These results demonstrate that perfusion-based fMRI using CASL with a separate labeling coil can now be used to characterize task-related flow changes in most of the brain volume with adequate accuracy and sensitivity.
Disciplines :
Radiology, nuclear medicine & imaging
Author, co-author :
Garraux, Gaëtan ; Université de Liège - ULiège & Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD
Hallett, Mark; Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room 5N226, 10 Center Dr., MSC 1428, Bethesda, MD 20892-1428, USA
Talagala, S Lalith; cNIH MRI Research Facility, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-1428, USA
Language :
English
Title :
CASL fMRI of subcortico-cortical perfusion changes during memory-guided finger sequences
Publication date :
March 2005
Journal title :
NeuroImage
ISSN :
1053-8119
eISSN :
1095-9572
Publisher :
Academic Press Inc Elsevier Science, San Diego, United States - California
NINDS - National Institute of Neurological Disorders and Stroke F.R.S.-FNRS - Fonds de la Recherche Scientifique Fondation Léon Fredericq BAEF - Belgian American Educational Foundation OTAN - Organisation du traité de l'Atlantique Nord Horlait-Dapsens Foundations
G.K. Aguirre, J.A. Detre, E. Zarahn, and D.C. Alsop Experimental design and the relative sensitivity of BOLD and perfusion fMRI NeuroImage 15 2002 488 500
J.D. Allison, K.J. Meador, D.W. Loring, R.E. Figuaroa, and J.C. Wright Functional MRI cerebral activation and deactivation during finger movement Neurology 54 2000 135 142
D.C. Alsop, and J.A. Detre Reduced transit-time sensitivity in noninvasive magnetic resonance imaging of human cerebral blood flow J. Cereb. Blood Flow Metab. 16 1996 1236 1249
E.L. Barbier, L. Lamalle, and M. Decorps Methodology of brain perfusion imaging J. Magn. Reson. Imaging 13 2001 496 520
F. Binkofski, G.R. Fink, S. Geyer, G. Buccino, O. Gruber, N.J. Shah, J.G. Taylor, R.J. Seitz, K. Zilles, and H.J. Freund Neural activity in human primary motor cortex areas 4a and 4p is modulated differentially by attention to action J. Neurophysiol. 88 2002 514 519
Brett, M., Anton, J.L., Valabregue, R., Poline, J.B., 2002. Region of interest analysis using an SPM toolbox. Presented at the 8th International Conference on Functional Mapping of the Human Brain, Sendai, Japan. Available on CD-Rom in NeuroImage, Vol. 16, no. 2, abstract 497.
J.A. Butman, A.J. Rebmann, and S.L. Talagala Abstract. Measurement of regional cervical-cerebral arterial transit time at high temporal resolution using dynamic susceptibility contrast Proceedings of the 10th Annual Meeting of ISMRM, Honolulu, HI, USA 2002 1076
R.B. Buxton, L.R. Frank, E.C. Wong, B. Siewert, S. Warach, and R.R. Edelman A general kinetic model for quantitative perfusion imaging with arterial spin labeling Magn. Reson. Med. 40 1998 383 396
M.J. Catalan, M. Honda, R.A. Weeks, L.G. Cohen, and M. Hallett The functional neuroanatomy of simple and complex sequential finger movements: a PET study Brain 121 1998 253 264
K.-H. Chuang, S. Chesnick, A.P. Koretsky, and S.L. Talagala Abstract. Optimization of the labeling time for continuous arterial spin labeling MRI Proc. ISMRM 11 2004 1364
J.G. Colebatch, M.-P. Deiber, R.E. Passingham, K.J. Friston, and R.S.J. Frackowiak Regional cerebral blood flow during voluntary arm and hand movements J. Neurophysiol. 65 1991 1392 1401
M.-P. Deiber, V. Ibanez, N. Sadato, and M. Hallett Cerebral structures participating in motor preparation in humans: a positron emission tomography study J. Neurophysiol. 75 1996 233 247
J.A. Detre, J.S. Leigh, D.S. Williams, and A.P. Koretsky Perfusion imaging Magn. Reson. Med. 23 1992 37 45
T.Q. Duong, D.S. Kim, K. Ugurbil, and S.G. Kim Localized cerebral blood flow response at submillimeter columnar resolution Proc. Natl. Acad. Sci. U. S. A. 98 2001 10904 10909
H.M. Duvernoy The human brain Surface, Blood Supply, and Three Dimensional Sectional Anatomy second ed. 1999 Springer-Verlag Wien New York
R.R. Edelman, B. Siewert, D.G. Darby, V. Thangaraj, A.C. Nobre, M.M. Mesulam, and S. Warach Qualitative mapping of cerebral blood flow and functional localization with echo-planar MR imaging and signal targeting with alternating radio frequency Radiology 192 1994 513 520
S.D. Forman, J.D. Cohen, M. Fitzgerald, W.F. Eddy, M.A. Mintun, and D.C. Noll Improved assessment of significant activation in functional magnetic resonance imaging (fMRI): use of a cluster-size threshold Magn. Reson.Med. 33 1995 636 647
R.S. Frackowiak, G.L. Lenzi, T. Jones, and J.D. Heather Quantitative measurement of regional cerebral blood flow and oxygen metabolism in man using 15O and positron emission tomography: theory, procedure, and normal values J. Comput. Assist. Tomogr. 4 1980 727 736
K.J. Friston, C.D. Frith, P.F. Liddle, R.J. Dolan, A.A. Lammerstma, and R.S.J. Frackowiak The relationship between global and local changes in PET scans J. Cereb. Blood Flow Metab. 10 1990 458 466
K.J. Friston, A.P. Holmes, K.J. Worsley, J.B. Poline, C.D. Frith, and R.S.J. Frackowiak Statistical parametric maps in functional imaging: a general linear approach Hum. Brain Mapp. 2 1995 189 210
K.J. Friston, A.P. Holmes, C.J. Price, C. Buchel, and K.J. Worsley Multisubject fMRI studies and conjunction analyses NeuroImage 10 1999 385 396
C.R. Genovese, N.A. Lazar, and T. Nichols Thresholding of statistical maps in functional neuroimaging using the false discovery rate NeuroImage 15 2002 870 878
S. Geyer, A. Ledberg, A. Schleicher, S. Kinomura, T. Schormann, U. Burgel, T. Klingberg, J. Larsson, K. Zilles, and P.E. Roland Two different areas within the primary motor cortex of man Nature 382 1996 805 807
J.B. Gonzalez-At, D.C. Alsop, and J.A. Detre Cerebral perfusion and arterial transit time changes during task activation determined with continuous arterial spin labeling Magn. Reson. Med. 43 2000 739 746
S.T. Grafton, E. Hazeltine, and R. Ivry Functional mapping of sequence learning in normal humans J. Cogn. Neurosci. 7 1995 497 510
F. Hamzei, C. Dettmers, R. Rzanny, J. Liepert, C. Buchel, and C. Weiller Reduction of excitability ("inhibition") in the ipsilateral primary motor cortex is mirrored by fMRI signal decreases NeuroImage 17 2002 490 496
B. Haslinger, P. Erhard, F. Weilke, A.O. Ceballos-Baumann, P. Bartenstein, v.E. Grafin, M. Schwaiger, B. Conrad, and H. Boecker The role of lateral premotor-cerebellar-parietal circuits in motor sequence control: a parametric fMRI study Brain Res. Cogn. Brain Res. 13 2002 159 168
L. Hernandez-Garcia, G.R. Lee, A.L. Vazquez, and D.C. Noll Fast, pseudo-continuous arterial spin labeling for functional imaging using a two-coil system Magn. Reson. Med. 51 2004 577 585
P. Herscovitch, and M.E. Raichle What is the correct value for the brain-blood partition coefficient for water J. Cereb. Blood Flow Metab. 5 1985 65 69
A.P. Holmes, and K.J. Friston Generalisability, random effects, and population inference NeuroImage 7 1998 754
J.C. Hsieh, H. Cheng, H.M. Hsieh, K.K. Liao, Y.T. Wu, T.C. Yeh, and L.T. Ho Loss of interhemispheric inhibition on the ipsilateral primary sensorimotor cortex in patients with brachial plexus injury: fMRI study Ann. Neurol. 51 2002 381 385
I.H. Jenkins, M. Jahanshahi, M. Jueptner, R.E. Passingham, and D.J. Brooks Self-initiated versus externally triggered movements: II. The effects of movement predictability on regional cerebral blood flow Brain 123 2000 1216 1228
S.G. Kim Quantification of relative cerebral blood flow change by flow-sensitive alternating inversion recovery (FAIR) technique: application to functional mapping Magn. Reson. Med. 34 1995 293 301
L. Maillard, K. Ishii, K. Bushara, D. Waldvogel, A.E. Schulman, and M. Hallett Mapping the basal ganglia. fMRI evidence for somatotopic representation of face, hand, and foot Neurology 55 2000 377 383
V. Menon, R.T. Anagnoson, G.H. Glover, and A. Pfefferbaum Basal ganglia involvement in memory-guided movement sequencing NeuroReport 11 2000 3641 3645
T. Mildner, R. Trampel, H.E. Moller, A. Schafer, C.J. Wiggins, and D.G. Norris Functional perfusion imaging using continuous arterial spin labeling with separate labeling and imaging coils at 3 T Magn. Reson. Med. 49 2003 791 795
B. Milner Interhemispheric differences in the localization of psychological processes in man Br. Med. Bull. 27 1971 272 277
R.C. Oldfield The assessment and analysis of handedness: the Edinburgh inventory Neuropsychologia 9 1970 97 113
N. Picard, and P.L. Strick Imaging the premotor areas Curr. Opin. Neurobiol. 11 2001 663 672
M.E. Raichle, A.M. MacLeod, A.Z. Snyder, W.J. Powers, D.A. Gusnard, and G.L. Shulman A default mode of brain function Proc. Natl. Acad. Sci. U. S. A. 98 2001 676 682
H. Reddy, P.M. Matthews, and M. Lassonde Functional MRI cerebral activation and deactivation during finger movement Neurology 55 2000 1244
N. Sadato, G. Campbell, V. Ibanez, M. Deiber, and M. Hallett Complexity affects regional cerebral blood flow change during sequential finger movements J. Neurosci. 16 1996 2693 2700
N. Sadato, V. Ibanez, G. Campbell, M.-P. Deiber, D. Le Bihan, and M. Hallett Frequency-dependent changes of regional cerebral blood flow during finger movements: functional MRI compared to PET J. Cereb. Blood. Flow Metab. 17 1997 670 679
K. Sakai, O. Hikosaka, S. Miyauchi, R. Takino, Y. Sasaki, and B. Pütz Transition of brain activation from frontal to parietal areas in visuomotor sequence learning J. Neurosci. 18 1998 1827 1840
A. Shmuel, E. Yacoub, J. Pfeuffer, P.F. Van de Moortele, G. Adriany, X. Hu, and K. Ugurbil Sustained negative BOLD, blood flow and oxygen consumption response and its coupling to the positive response in the human brain Neuron 36 2002 1195 1210
A.C. Silva, W. Zhang, D.S. Williams, and A.P. Koretsky Multi-slice MRI of rat brain perfusion during amphetamine stimulation using arterial spin labeling Magn. Reson. Med. 33 1995 209 214
S.L. Talagala, and D.C. Noll Functional MRI using steady-state arterial water labeling Magn. Reson. Med. 39 1998 179 183
S.L. Talagala, F.Q. Ye, P.J. Ledden, and S. Chesnick Whole brain 3D perfusion MRI at 3.0 T using CASL with a separate labeling coil Magn. Reson. Med. 52 2004 131 140
S.L. Talagala, K.-H. Chuang, S. Chesnick, P. van Gelderen, A.P. Koretsky, and J. Duyn Abstract. High sensitivity CASL perfusion MRI at 3T using a 16 channel receiver coil array Proc. ISMRM 11 2004 717
J. Talairach, and P. Tournoux Coplanar stereotaxic atlas of the human brain 3-Dimensional Proportional System: An Approach to Cerebral Imaging 1988 Thieme Medical Stuttgart
G.W. Thickbroom, M.L. Byrnes, P. Sacco, S. Ghosh, I.T. Morris, and F.L. Mastaglia The role of the supplementary motor area in externally timed movement: the influence of predictability of movement timing Brain Res. 874 2000 233 241
M.J. Thieben, A.J. Duggins, C.D. Good, L. Gomes, N. Mahant, F. Richards, E. McCusker, and R.S. Frackowiak The distribution of structural neuropathology in pre-clinical Huntington's disease Brain 125 2002 1815 1828
I. Toni, N.J. Shah, G.R. Fink, D. Thoenissen, R.E. Passingham, and K. Zilles Multiple movement representations in the human brain: an event-related fMRI study J. Cogn. Neurosci. 14 2002 769 784
J. Wang, D.C. Alsop, L. Li, J. Listerud, J.B. Gonzalez-At, M.D. Schnall, and J.A. Detre Comparison of quantitative perfusion imaging using arterial spin labeling at 1.5 and 4.0 Tesla Magn. Reson. Med. 48 2002 242 254
J. Wang, G.K. Aguirre, D.Y. Kimberg, A.C. Roc, L. Li, and J.A. Detre Arterial spin labeling perfusion fMRI with very low task frequency Magn. Reson. Med. 49 2003 796 802
J. Wang, G.K. Aguirre, D.Y. Kimberg, and J.A. Detre Empirical analyses of null-hypothesis perfusion FMRI data at 1.5 and 4 T NeuroImage 19 2003 1449 1462
D.S. Williams, J.A. Detre, J.S. Leigh, and A.P. Koretsky Magnetic resonance imaging of perfusion using spin inversion of arterial water Proc. Natl. Acad. Sci. U. S. A. 89 1992 212 216
E.C. Wong, R.B. Buxton, and L.R. Frank Implementation of quantitative perfusion imaging techniques for functional brain mapping using pulsed arterial spin labeling NMR Biomed. 10 1997 237 249
F.Q. Ye, A.M. Smith, Y. Yang, J. Duyn, V.S. Mattay, U.E. Ruttimann, J.A. Frank, D.R. Weinberger, and A.C. McLaughlin Quantitation of regional cerebral blood flow increases during motor activation: a steady-state arterial spin tagging study NeuroImage 6 1997 104 112
F.Q. Ye, K.F. Berman, T. Ellmore, G. Esposito, J.D. Van Horn, Y. Yang, J. Duyn, A.M. Smith, J.A. Frank, D.R. Weinberger, and A.C. McLaughlin H(2)(15)O PET validation of steady-state arterial spin tagging cerebral blood flow measurements in humans Magn. Reson. Med. 44 2000 450 456
M.N. Yongbi, F. Fera, Y. Yang, J.A. Frank, and J.H. Duyn Pulsed arterial spin labeling: comparison of multisection baseline and functional MR imaging perfusion signal at 1.5 and 3.0 T: initial results in six subjects Radiology 222 2002 569 575
T.A. Yousry, U.D. Schmid, H. Alkadhi, D. Schmidt, A. Peraud, A. Buettner, and P. Winkler Localization of the motor hand area to a knob on the precentral gyrus. A new landmark Brain 120 Pt 1 1997 141 157
G. Zaharchuk, P.J. Ledden, K.K. Kwong, T.G. Reese, B.R. Rosen, and L.L. Wald Multislice perfusion and perfusion territory imaging in humans with separate label and image coils Magn. Reson. Med. 41 1999 1093 1098
M.R. Zaini, S.C. Strother, J.R. Anderson, J.S. Liow, U. Kjems, C. Tegeler, and S.G. Kim Comparison of matched BOLD and FAIR 4.0 T-fMRI with [15O]water PET brain volumes Med. Phys. 26 1999 1559 1567
W. Zhang, A.C. Silva, D.S. Williams, and A.P. Koretsky NMR measurement of perfusion using arterial spin labeling without saturation of macromolecular spins Magn. Reson. Med. 33 1995 370 376
