[en] No consistent cerebral anatomical abnormality has ever been reported in primary focal hand dystonia (FHD). The present voxel-based morphometry study showed a significant bilateral increase in gray matter in the hand representation area of primary somatosensory and, to a lesser extent, primary motor cortices in 36 patients with unilateral FHD compared with 36 controls. The presence of anatomical changes in the perirolandic cortex for the unaffected hand as well as that for the affected hand suggests that these disturbances may be, at least in part, primary.
Disciplines :
Neurology
Author, co-author :
Garraux, Gaëtan ; Université de Liège - ULiège & Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD
Bauer, Andrew; Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD
Hanakawa, Takashi; Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD
Wu, Tao; Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD
Kansaku, Kenji; Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD
Hallett, M.; Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD
Language :
English
Title :
Changes in brain anatomy in focal hand dystonia
Publication date :
May 2004
Journal title :
Annals of Neurology
ISSN :
0364-5134
eISSN :
1531-8249
Publisher :
Wiley Liss, Inc., New York, United States - New York
NINDS - National Institute of Neurological Disorders and Stroke Horlait-Dapsens Foundations BAEF - Belgian American Educational Foundation OTAN - Organisation du traité de l'Atlantique Nord Fondation Léon Fredericq F.R.S.-FNRS - Fonds de la Recherche Scientifique
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