Natural Killer cells - role in local tumor growth and metastasis

Langers, Inge; Renoux, Virginie; Thiry, Marc; Delvenne, Philippe; Jacobs, Nathalie

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Natural Killer cells - role in local tumor growth and metastasis

Langers, Inge; Renoux, Virginie; Thiry, Marc et al.

2012 • In Biologics: Targets and Therapy

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Keywords :

Natural killer; tumor; cytotoxicity

Abstract :

[en] Historically, the name of Natural Killer (NK) cells came from their natural ability to kill tumor cells in vitro. From the seventies to date, accumulating data highlighted the importance of NK cells in host immune response against cancer and in therapy-induced anti-tumor response. The recognition and the lysis of tumor cells by NK cells are regulated by a complex balance of inhibitory and activating signals. This review summarizes NK cell mechanisms to kill cancer cells, their role in host immune responses against tumor growth or metastasis and their implications in anti-tumor immunotherapies via cytokines, antibodies or in combination with other therapies. The regulatory role of NK cells in autoimmunity is also discussed.

Research Center/Unit :

GIGA-I3 - Giga-Infection, Immunity and Inflammation - ULiège
Giga-Cancer - ULiège

Disciplines :

Oncology
Immunology & infectious disease

Author, co-author :

Langers, Inge ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques

Renoux, Virginie ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques

Thiry, Marc ; Université de Liège - ULiège > Département des sciences de la vie > Biologie cellulaire

Delvenne, Philippe ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques

Jacobs, Nathalie ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Anatomie et cytologie pathologiques

Language :

English

Title :

Natural Killer cells - role in local tumor growth and metastasis

Publication date :

April 2012

Journal title :

Biologics: Targets and Therapy

ISSN :

1177-5475

eISSN :

1177-5491

Publisher :

Dove Medical Press, Auckland, New Zealand

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

http://reflexions.ulg.ac.be/CellulesNK

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique
Télévie

Available on ORBi :

since 02 March 2012

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137

Scopus citations^®
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134

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