Voxel-based distribution of metabolic impairment in corticobasal degeneration

[en] This report emphasizes the precise topographic distribution of cerebral metabolic impairment in corticobasal degeneration (CBD) and the pathophysiological differences between CBD and progressive supranuclear palsy (PSP). Statistical parametric mapping (SPM96) analysis of 18FDG positron emission tomography (PET) data was performed in 22 patients with CBD compared with 46 healthy subjects (HS) and 21 patients with PSP who were studied at rest. A statistical threshold of p <0.001 was fixed, further corrected for multiple or independent comparisons (p <0.05). In comparison with HS, the metabolic impairment in CBD was asymmetrically distributed in the putamen, thalamus, precentral (Brodmann's area, BA 4), lateral premotor (BA 6/44) and supplementary motor areas (SMA, BA 6), dorsolateral prefrontal (8/9/46) cortex, and the anterior part of the inferior parietal lobe (BA 40) including the intraparietal sulcus (BA 7/40). A similar hypometabolic pattern was observed for most individual analyses. When PSP was compared with CBD, metabolic impairment predominated in the midbrain, anterior cingulate (BA 24/32), and orbitofrontal regions (BA 10). The reverse contrast showed more posterior involvement in CBD (BA 6 and 5/7/40) including SMA. Our data suggest that multiple components of neural networks related to both movement execution and production of skilled movements are functionally disturbed in CBD compared with both HS and PSP.

Research Center/Unit :

GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège

Disciplines :

Neurology
Radiology, nuclear medicine & imaging
Neurosciences & behavior

Author, co-author :

Garraux, Gaëtan ; Université de Liège - ULiège > Centre de Recherches du Cyclotron et Département des sciences cliniques > Neurologie

Salmon, Eric ; Université de Liège - ULiège > Centre de Recherches du Cyclotron et Département des sciences cliniques > Neurologie

Peigneux, Philippe ; Université de Liège - ULiège > Centre de Recherches du Cyclotron et Département des sciences cognitives

Kreisler, Alexandre; Université de Lille > CHRU > Neurologie

Degueldre, Christian ; Université de Liège - ULiège > Centre de recherches du cyclotron

Lemaire, Christian ; Université de Liège - ULiège > Centre de recherches du cyclotron

Destee, Alain; Université de Lille > CHRU > Neurologie

Franck, Georges ; Université de Liège - ULiège > Département des sciences cliniques > Neurologie

Language :

English

Title :

Voxel-based distribution of metabolic impairment in corticobasal degeneration

Publication date :

September 2000

Journal title :

Movement Disorders

ISSN :

0885-3185

eISSN :

1531-8257

Publisher :

John Wiley & Sons

Volume :

Issue :

Pages :

894-904

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

http://www3.interscience.wiley.com/journal/76508371/abstract

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique

Available on ORBi :

since 16 April 2009

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