Reference : Medial temporal lobe metabolic impairment in dementia associated with motor neuron disease
Scientific journals : Article
Human health sciences : Neurology
http://hdl.handle.net/2268/11307
Medial temporal lobe metabolic impairment in dementia associated with motor neuron disease
English
Garraux, Gaëtan mailto [Université de Liège - ULiège > Centre de Recherches du Cyclotron et Département des sciences cliniques > Neurologie > > >]
Salmon, Eric mailto [Université de Liège - ULiège > Centre de Recherches du cyclotron et Département des sciences cliniques > Neurologie > >]
Degueldre, Christian mailto [Université de Liège - ULiège > > Centre de recherches du cyclotron >]
Lemaire, Christian mailto [Université de Liège - ULiège > > Centre de recherches du cyclotron >]
Franck, Georges [Université de Liège - ULiège > Département des sciences cliniques > Neurologie > >]
15-Oct-1999
Journal of the Neurological Sciences
Elsevier Science Bv
168
2
145-150
Yes (verified by ORBi)
International
0022-510X
Amsterdam
Netherlands
[en] Motor neuron disease ; Dementia ; Positron emission tomography ; Medial temporal lobe
[en] In the course of their disease certain patients with frontotemporal dementia (FTD) develop clinical features compatible with a motor neuron disease (FTD-MND). Previous reports have suggested that the functional pattern is similar in FTD and FTD-MND. However, some neuropathological studies suggest greater involvement of medial temporal regions in FTD-MND than in FTD. Using statistical parametric mapping (SPM96), we compared the metabolic patterns obtained at rest with positron emission tomography in 10 FTD patients and three FTD-MND patients with those obtained from 46 healthy subjects (HS). Mean age, duration of illness and dementia stage did not differ statistically between the FTD and FTD-MND groups. In comparison with HS, both groups showed frontal and anterior temporal hypometabolism at P<0.001. When the FTD-MND group was compared to the FTD group, significant hypometabolism was only observed in bilateral amygdala, bilateral hippocampus, and bilateral enthorinal and parahippocampal regions (Brodmann's areas, BA 28/36) at P<0.005. We found no significant differences in regional glucose uptake when FTD patients were contrasted to FTD-MND patients. Our results suggest statistically comparable frontal and lateral temporal hypometabolism in both conditions but greater impairment of medial temporal lobe activity in FTD-MND. Our results and a review of the literature support the hypothesis that there is a functional continuum between classical motor neuron disease (cMND), FTD-MND, and FTD.
Centre de Recherches du Cyclotron - CRC
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Researchers ; Professionals
http://hdl.handle.net/2268/11307
10.1016/S0022-510X(99)00188-4
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T06-3XMPN76-G&_user=532038&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000026659&_version=1&_urlVersion=0&_userid=532038&md5=662ed1c5847c566a8f623fda1a3cf90f

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