Reference : Type II collagen peptides for measuring cartilage degradation
Scientific journals : Article
Human health sciences : Laboratory medicine & medical technology
Human health sciences : Hematology
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/111206
Type II collagen peptides for measuring cartilage degradation
English
Henrotin, Yves mailto [Université de Liège - ULiège > > Unité de recherche sur l'os et le cartillage (U.R.O.C.) >]
Deberg, Michelle mailto [Université de Liège - ULiège > > Unité de recherche sur l'os et le cartillage (U.R.O.C.) >]
Dubuc, J. E. [> > > >]
Quettier, E. [> > > >]
Christgau, S. [> > > >]
Reginster, Jean-Yves mailto [Université de Liège - ULiège > Département des sciences de la santé publique > Epidémiologie et santé publique >]
2004
Biorheology
Ios Press
41
3-4
543-547
Yes (verified by ORBi)
International
0006-355X
Amsterdam
Netherlands
[en] ageing ; osteoarthritis ; biological markers ; nitric oxide ; oxygen
[en] This paper describes two new immunoassays for a peptide of the triple helix of type II collagen (Coll 2-1) and its nitrated form (Coll 2-1 NO2). In healthy subjects aged between 20 and 65 years old, Coll 2-1 and Coll 2-1 NO2 levels in serum were in means 125.13+/-3.71 and 0.16+/-0.08 nmol/l, respectively. These levels did not significantly vary with age. However, up to 45 years of age, Coll 2-1 NO2 levels in women were significantly higher than in men. In patients with knee osteoarthritis (OA), Coll 2-1 in serum was found to be elevated compared to healthy controls (267.45+/-26.42 nmol/l vs 126.78+/-6.61 nmol/l). Further, we have demonstrated that an increase of the urinary levels of Coll 2-1 or Coll 2-1 NO2 over 1 year was predictive of joint space narrowing progression in OA patients. In conclusion, these preliminary results indicate that Coll 2-1 could be a predictive marker of knee OA progression.
http://hdl.handle.net/2268/111206

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