Article (Scientific journals)
Effect of collagen hydrolysate in articular pain: A 6-month randomized, double-blind, placebo controlled study
Bruyère, Olivier; Zegels, Brigitte; Leonori, Lorenzo et al.
2012In Complementary Therapies in Medicine, 20, p. 124-130
Peer Reviewed verified by ORBi
 

Files


Full Text
Effect of collagen hydrolysate in articular pain....pdf
Publisher postprint (277.94 kB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Joint; Nutrition; Collagen hydrolysate; Pain; Randomized controlled study
Abstract :
[en] Objective: Evaluation of the efficacy and safety of a food supplement made of collagen hydrolysate 1200 mg/day versus placebo during 6 months, in subjects with joint pain at the lower or upper limbs or at the lumbar spine. Design: Comparative double-blind randomized multicenter study in parallel groups. Setting: 200 patients of both genders of at least 50 years old with joint pain assessed as ≥30 mm on a visual analogical scale (VAS). Intervention: Collagen hydrolysate 1200 mg/day or placebo during 6 months. Main outcome measure: Comparison of the percentage of clinical responder between the active collagen hydrolysate group and the placebo group after 6 months of study. A responder subject was defined as a subject experiencing a clinically significant improvement (i.e. by 20% or more) in the most painful joint using the VAS score. All analyses were performed using an intent-totreat procedure. Results: At 6 months, the proportion of clinical responders to the treatment, according to VAS scores, was significantly higher in the collagen hydrolysate (CH) group 51.6%, compared to the placebo group 36.5% (p < 0.05). However, there was no significant difference between groups at 3 months (44.1% vs. 39.6%, p = 0.53). No significant difference in terms of security and tolerability was observed between the two groups. Conclusions: This study suggests that collagen hydrolysate 1200 mg/day could increase the number of clinical responders (i.e. improvement of at least 20% on the VAS) compared to placebo. More studies are needed to confirm the clinical interest of this food supplement.
Disciplines :
Public health, health care sciences & services
General & internal medicine
Author, co-author :
Bruyère, Olivier  ;  Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé
Zegels, Brigitte ;  Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé
Leonori, Lorenzo;  Centre Hospitalier Universitaire de Liège - CHU > BRULL
Rabenda, Véronique ;  Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé
Janssen, A.
Bourges, C.
Reginster, Jean-Yves  ;  Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé
Language :
English
Title :
Effect of collagen hydrolysate in articular pain: A 6-month randomized, double-blind, placebo controlled study
Publication date :
2012
Journal title :
Complementary Therapies in Medicine
ISSN :
0965-2299
Publisher :
Harcourt Brace & Company Ltd.
Volume :
20
Pages :
124-130
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
Nutraveris
Available on ORBi :
since 06 February 2012

Statistics


Number of views
161 (30 by ULiège)
Number of downloads
9 (9 by ULiège)

Scopus citations®
 
43
Scopus citations®
without self-citations
42
OpenCitations
 
34

Bibliography


Similar publications



Contact ORBi