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Non Small Cell Lung Carcinoma (Nsclc) at Stage 3. A Fourteen Years Retrospective Study of 449 Patients. Indications of Surgery in a Multidisciplinary Management
RADERMECKER, Marc; Dekoster, Guy; Minet, P. et al.
1989In Acta Chirurgica Belgica, 89 (3, May-Jun), p. 153-8
 

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Abstract :
[en] Through a fourteen years retrospective study of all the patients treated at the State University of Liege, we have focused on the survival of 449 patients with, at least, a clinical stage 3 NSCLC disease (NORMS UICC). The whole study was divided in two periods (1972-1978, period 1, and 1979-1985, period 2) because, everything remaining nearly equal as far as the clinical material was concerned, period 2 was characterized by a different therapeutic attitude. Since 1979, the NSCLC stage 3's surgical indications have been widely extended. We have performed surgical resections in patients with NSCLC N2 disease because of positive homolateral mediastinal lymph nodes or with T3 disease. This led the NSCLC stage 3 resection rate to move from 26% in period 1 to 47% in period 2. We report here the effects of such a management on the short and long term survival and the stage 3 NSCLC global prognosis. We noted a modest significant increase in the NSCLC stage 3 global prognosis with a five year survival of 4% and 6% (period 1 and 2 respectively; P = 0.03). The 172 resected patients' outcome did not change (five year survival 11% (P1) and 12% (P2]. Although patients were not randomized, our results suggest that adjuvant therapy should not be added whenever the patient underwent a complete resection. On the other hand, it seems very useful indeed whenever the resection was partial. NSCLC patient at stage 3 who underwent a complete resection achieved a 37% five years survival.
Disciplines :
Surgery
Author, co-author :
RADERMECKER, Marc ;  Centre Hospitalier Universitaire de Liège - CHU > Chirurgie cardio-vasculaire
Dekoster, Guy ;  Université de Liège - ULiège > Département des sciences de la santé publique > Département des sciences de la santé publique
Minet, P.
Lavigne, Jean-Paul ;  Centre Hospitalier Universitaire de Liège - CHU > Chirurgie cardio-vasculaire
Honoré, D.
Limet, Raymond ;  Université de Liège - ULiège > Département des sciences cliniques > Chirurgie cardio-vasculaire et thoracique
Language :
English
Title :
Non Small Cell Lung Carcinoma (Nsclc) at Stage 3. A Fourteen Years Retrospective Study of 449 Patients. Indications of Surgery in a Multidisciplinary Management
Publication date :
1989
Journal title :
Acta Chirurgica Belgica
ISSN :
1784-3421
eISSN :
2577-0160
Publisher :
Taylor & Francis, United Kingdom
Volume :
89
Issue :
3, May-Jun
Pages :
153-8
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