Role of Biochemical Markers of Bone Turnover as Prognostic Indicator of Successful Osteoporosis Therapy

[en] Most of the currently available anti-osteoporosis medications promptly and significantly influence the rate of bone turnover. Biochemical markers of bone turnover now provide a high sensitivity to change, allowing the detection of these bone turnover changes within a couple of weeks. Since the anti-fracture efficacy of inhibitors of bone resorption or stimulators of bone formation appears to be largely independent of baseline bone turnover, biochemical markers do not appear to play a significant role in the selection of one particular drug, for an individual patient. However, there are consistent data showing that short-term changes in biochemical markers of bone turnover may be significant predictors of future changes in bone mineral density or fracture reduction, hence suggesting that bone turnover markers play a significant role in the monitoring of anti-osteoporosis therapy.

Disciplines :

Rheumatology

Author, co-author :

Reginster, Jean-Yves ; Université de Liège - ULiège > Département des sciences de la santé publique > Epidémiologie et santé publique

Collette, Julien ; Centre Hospitalier Universitaire de Liège - CHU > Chimie médicale

NEUPREZ, Audrey ; Université de Liège - ULiège > Département des Sicences de la Santé Publique > Epidémiologie et santé publique

Zegels, Brigitte ; Université de Liège - ULiège > Département des sciences de la santé publique > Epidémiologie et santé publique

Deroisy, Rita ; Centre Hospitalier Universitaire de Liège - CHU > Médecine de l'appareil locomoteur

Bruyère, Olivier ; Université de Liège - ULiège > Département des sciences de la santé publique > Epidémiologie et santé publique

Language :

English

Title :

Role of Biochemical Markers of Bone Turnover as Prognostic Indicator of Successful Osteoporosis Therapy

Publication date :

10 February 2008

Journal title :

BONE

ISSN :

8756-3282

eISSN :

1873-2763

Publisher :

Elsevier, Netherlands

Volume :

Pages :

832-836

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

http://www.elsevier.com/wps/find/journaldescription.cws_home/525233/description#description

Available on ORBi :

since 14 April 2009

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