[en] Background: Asthma diagnosis is based on the presence of symptoms and the demonstration of airflow variability. Airway inflammation measured by fractional exhaled nitric oxide, measured at a flow rate of 50 ml/s (FE(NO50) ) remains a controversial diagnostic tool. Aim: To assess the ability of FE(NO50) to identify bronchial hyperresponsiveness (BHR) to methacholine (provocative concentration of methacholine causing a 20% fall in FEV(1) ; PC20M /= 70% predicted and no demonstrated reversibility to beta(2) -agonist. Patients answered to a standardised symptom questionnaire and underwent FE(NO50) and methacholine challenge. Receiver-operating characteristic (ROC) curve and logistic regression analysis assessed the relationship between PC20M and FE(NO50) , taking into account covariates (smoking, atopy, age, gender and FEV(1) ). Results: A total of 82 patients had a PC20M 34 ppb has high predictive value of PC20M < 16 in patients with suspected asthma in whom bronchodilating test failed to demonstrate reversibility or was not indicated. However, FE(NO50)
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
SCHLEICH, FLorence ; Centre Hospitalier Universitaire de Liège - CHU > Pneumologie-Allergologie
ASANDEI, Raluca ; Centre Hospitalier Universitaire de Liège - CHU > Pneumologie-Allergologie
Manise, Maïté ; Université de Liège - ULiège > Département des sciences cliniques > Pneumologie - Allergologie
SELE, Jocelyne ; Centre Hospitalier Universitaire de Liège - CHU > Pneumologie-Allergologie
Seidel, Laurence ; Université de Liège - ULiège > Département des sciences de la santé publique > Informatique médicale et biostatistique
LOUIS, Renaud ; Centre Hospitalier Universitaire de Liège - CHU > Pneumologie-Allergologie
Language :
English
Title :
Is FE(NO50) useful diagnostic tool in suspected asthma?
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