Article (Scientific journals)
Nitric oxide and cardiac function: ten years after, and continuing.
MASSION, Paul; Feron, O.; Dessy, C. et al.
2003In Circulation Research, 93 (5), p. 388-98
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Keywords :
Animals; Heart/physiology/physiopathology; Heart Diseases/physiopathology; Humans; Myocardial Contraction/physiology; Nitric Oxide/metabolism; Nitric Oxide Synthase/metabolism; Nitric Oxide Synthase Type I
Abstract :
[en] Nitric oxide (NO) is produced from virtually all cell types composing the myocardium and regulates cardiac function through both vascular-dependent and -independent effects. The former include regulation of coronary vessel tone, thrombogenicity, and proliferative and inflammatory properties as well as cellular cross-talk supporting angiogenesis. The latter comprise the direct effects of NO on several aspects of cardiomyocyte contractility, from the fine regulation of excitation-contraction coupling to modulation of (presynaptic and postsynaptic) autonomic signaling and mitochondrial respiration. This multifaceted involvement of NO in cardiac physiology is supported by a tight molecular regulation of the three NO synthases, from cellular spatial confinement to posttranslational allosteric modulation by specific interacting proteins, acting in concert to restrict the influence of NO to a particular intracellular target in a stimulus-specific manner. Loss of this specificity, such as produced on excessive NO delivery from inflammatory cells (or cytokine-stimulated cardiomyocytes themselves), may result in profound cellular disturbances leading to heart failure. Future therapeutic manipulations of cardiac NO synthesis will necessarily draw on additional characterization of the cellular and molecular determinants for the net effect of this versatile radical on the cardiomyocyte biology.
Disciplines :
Anesthesia & intensive care
Author, co-author :
MASSION, Paul ;  Centre Hospitalier Universitaire de Liège - CHU > Soins intensifs
Feron, O.
Dessy, C.
Balligand, J*-L
Language :
English
Title :
Nitric oxide and cardiac function: ten years after, and continuing.
Publication date :
2003
Journal title :
Circulation Research
ISSN :
0009-7330
eISSN :
1524-4571
Publisher :
Lippincott Williams & Wilkins, Baltimore, United States - Maryland
Volume :
93
Issue :
5
Pages :
388-98
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 30 January 2012

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