Article (Scientific journals)
Are blood transfusions associated with greater mortality rates? Results of the Sepsis Occurrence in Acutely Ill Patients study.
Vincent, Jean-Louis; Sakr, Yasser; Sprung, Charles et al.
2008In Anesthesiology, 108 (1), p. 31-9
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Keywords :
Adult; Aged; Blood Transfusion/mortality/trends; Critical Illness/mortality; Female; Humans; Male; Middle Aged; Prospective Studies; Sepsis/mortality/therapy; Survival Rate/trends
Abstract :
[en] BACKGROUND: Studies have suggested worse outcomes in transfused patients and improved outcomes in patients managed with restricted blood transfusion strategies. The authors investigated the relation of blood transfusion to mortality in European intensive care units (ICUs). METHODS: The Sepsis Occurrence in Acutely Ill Patients study was a multicenter, observational study that included all adult patients admitted to 198 European ICUs between May 1 and May 15, 2002 and followed them until death, until hospital discharge, or for 60 days. Patients were classified depending on whether they had received a blood transfusion at any time during their ICU stay. RESULTS: Of 3,147 patients, 1,040 (33.0%) received a blood transfusion. These patients were older (mean age, 62 vs. 60 yr; P = 0.035) and were more likely to have liver cirrhosis or hematologic cancer, to be a surgical admission, and to have sepsis. They had a longer duration of ICU stay (5.9 vs. 2.5 days; P < 0.001) and a higher ICU mortality rate (23.0 vs. 16.3%; P < 0.001) but were also more severely ill on admission (Simplified Acute Physiology Score II, 40.2 vs. 34.7; P < 0.001; Sequential Organ Failure Assessment score, 6.5 vs. 4.5; P < 0.001). There was a direct relation between the number of blood transfusions and the mortality rate, but in multivariate analysis, blood transfusion was not significantly associated with a worse mortality rate. Moreover, in 821 pairs matched according to a propensity score, there was a higher 30-day survival rate in the transfusion group than in the other patients (P = 0.004). CONCLUSION: This observational study does not support the view that blood transfusions are associated with increased mortality rates in acutely ill patients.
Disciplines :
Anesthesia & intensive care
Author, co-author :
Vincent, Jean-Louis
Sakr, Yasser
Sprung, Charles
Harboe, Svein
Damas, Pierre ;  Université de Liège - ULiège > Département des sciences cliniques > Anesthésie et réanimation
Language :
English
Title :
Are blood transfusions associated with greater mortality rates? Results of the Sepsis Occurrence in Acutely Ill Patients study.
Publication date :
2008
Journal title :
Anesthesiology
ISSN :
0003-3022
eISSN :
1528-1175
Publisher :
Lippincott Williams & Wilkins, Philadelphia, United States - Pennsylvania
Volume :
108
Issue :
1
Pages :
31-9
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 27 January 2012

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