Article (Scientific journals)
Loss of T cell microRNA provides systemic protection against autoimmune pathology in mice
Tian, L.; De Hertogh, G.; Fedeli, M. et al.
2012In Journal of Autoimmunity
Peer Reviewed verified by ORBi
 

Files


Full Text
Humblet-J Autoimmun-2012.pdf
Publisher postprint (1.98 MB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Dicer; microRNA; T cells; immune tolerance; autoimmunity
Abstract :
[en] With an increasing number of studies demonstrating alterations in T cell microRNA expression during autoimmune disease, modulation of the T cell microRNA network is considered a potential therapeutic strategy. Due to the complex and often opposing interactions of individual microRNA, prioritization of therapeutic targets first requires dissecting the dominant effects of the T cell microRNA network. Initial results utilizing a unidirectional screen suggested that the tolerogenic functions were dominanat, with spontaneous colitis resulting from T cell-specific excision of Dicer. Here we performed a bidirectional screen for microRNA function by removing Dicer from the T cells of both wildtype mice and Transforming Growth Factor β (TGFβ) receptor-deficient mice. This allowed the impact of microRNA loss on T cell activation, effector T cell differentiation and autoimmune pathology to be systematically assessed. This bidirectional screen revealed a dominant immunogenic functionfor T cell microRNA, with potent suppression of T cell activation, IFNγ production and autoimmune pathology in all targeted organs except the colon, where Dicer-dependent microRNA demonstrated a dominant tolerogenic function. These results reverse the original conclusions of microRNA function in T cells by revealing a systemic pro-autoimmune function.
Disciplines :
Hematology
Author, co-author :
Tian, L.
De Hertogh, G.
Fedeli, M.
Staats, K. A.
Schonefeldt, S.
Humblet, Stéphanie ;  Université de Liège - ULiège > GIGA-R : Hématologie
Van Den Bosch, L.
Dellabona, P.
Dooley, J.
Liston, A.
Language :
English
Title :
Loss of T cell microRNA provides systemic protection against autoimmune pathology in mice
Publication date :
2012
Journal title :
Journal of Autoimmunity
ISSN :
0896-8411
eISSN :
1095-9157
Publisher :
Academic Press, London, United Kingdom
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 27 January 2012

Statistics


Number of views
104 (6 by ULiège)
Number of downloads
1823 (2 by ULiège)

Scopus citations®
 
18
Scopus citations®
without self-citations
14
OpenCitations
 
20

Bibliography


Similar publications



Contact ORBi