[en] Objective
The aim of this study was to assess the impact of HIV-1 and placental malaria co-infection on newborn biometry and Apgar scores.
Methods
146 HIV-1 infected and 149 HIV-1 uninfected consent mothers and their newborns were recruited. Placental biopsies examination confirmed the presence or absence of placental malaria. Birth weight (BW), placental weight, cranial circumference, brachial perimeter, height, Body Mass Index (BMI) and Apgar scores at 1’, 5’, 10’ were taken.
The Chi2 test and t -Student test were used for data statistical analysis.
Results
The global placental malarial infection prevalence was 72% but was 91% in HIV-1 infected vs. 53.7% in HIV-1 uninfected mothers (p <0.0001). The mean BW of HIV-1 co-infected mother’s newborns was slightly inferior to that of HIV-1 uninfected mother’s babies (3,033±524g vs. 3,236±565g) but this difference was not statistically significant (p >0.05). No other significant biometric differences were noted (p >0.05). But, the co-infection influenced negatively Apgar scores at 5’ (p <0.05).
Conclusion
HIV-1 co-infected mothers were more frequently exposed to placental malaria infection. The co-infection reduced the Apgar scores taken at the fifth minute. [fr] But
Évaluation de l’impact de la co-infection paludéenne placentaire et du VIH sur la biométrie et l’indice d’Apgar du nouveau-né à Kinshasa.
Patients et méthodes
Cent quarante-six mères VIH+ et 149 VIH−, consentantes et leurs nouveau-nés ont été évalués. L’infection paludéenne placentaire a été confirmée par examen anatomopathologique. Les paramètres biométriques (poids de naissance [PN], poids du placenta [PP], périmètre crânien [PC], périmètre brachial [PB], taille, indice de masse corporel [IMC]) et les indices d’Apgar à la 1’, 5’, 10’ ont été prélevés. Les tests Chi2 et t -Student ont servi aux analyses statistiques des données.
Résultats
La prévalence globale de l’infection paludéenne placentaire était de 72 %, mais de 91 % pour les mères VIH+ vs 53,7 % pour les mères VIH− (p <0,0001). La co-infection a eu une légère influence sur le PN moyen (3,033±524g vs 3,236±565g) mais cette différence n’était pas statistiquement significative (p >0,05). Les autres paramètres biométriques n’ont pas été influencés par la co-infection (p >0,05). En revanche, la co-infection a une eu influence négative sur l’indice d’Apgar prélevé à la cinquième minute (p <0,05).
Conclusion
Les mères VIH+ ont été les plus exposées à l’infection paludéenne placentaire. La co-infection réduit l’indice d’Apgar à la cinquième minute.
Disciplines :
Reproductive medicine (gynecology, andrology, obstetrics)
Author, co-author :
Modia O'Yandjo, A.
Foidart, Jean-Michel ; Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique
RIGO, Jacques ; Centre Hospitalier Universitaire de Liège - CHU > Néonatologie CHR
Language :
English
Title :
Influence of HIV-1 and placental malaria co-infection on newborn biometry and Apgar scores in Kinshasa Democratic Republic of Congo
Alternative titles :
[en] Influence de la co-infection paludéenne placentaire et VIH sur la biométrie et l’indice d’Apgar du nouveau-né à Kinshasa, République démocratique du Congo
Publication date :
2011
Journal title :
Journal de Gynécologie, Obstétrique et Biologie de la Reproduction
K. Hewitt, R. Steketee, V. Mwapasa, J. Whitworth, and N. French Interactions between HIV and malaria in non-pregnant adults: evidence and implications AIDS 20 2006 1993
WHO. AIDS epidemic Update 2007. Regional Summaries 16 April 2008. http://www.unaids.org.
P.B. Bloland, J.J. Wirima, R.W. Steketee, B. Chilima, A. Hightower, and J.G. Breman Maternal HIV infection and infant mortality in Malawi: evidence for increased mortality due to placental malaria infection AIDS. 9 1995 721 726
B.J. Brabin, M. Ginny, J. Sapau, K. Galme, and J. Paino Consequence of maternal anaemia on outcome of pregnancy i malaria endemic area in Papua New Guinea Ann Trop Med Parasitol. 84 1990 11
M. Cot, and P. Deleron Paludisme associé la grossesse: conséquences et perspectives d'intervention Med Trop 63 2003 369 380 (Pubitemid 44490452)
C.J. Uneke Impact of placental Plasmodium falciparum malaria on pregnancy and perinatal outcome in sub-Saharan Africa: II: effects of placental malaria on perinatal outcome Yale J Biol Med. 80 2007 95 103
I.A. McGregor, M.E. Wilson, and W.Z. Billewicz Malaria infection of placenta in the Gambia West Africa; its incidence and relationship to stillbirth, birthweight, and placental weight Trans R Soc Trop Med Hyg 77 1983 232
R.W. Steketee, and B.L. Nahlen HIV increases the risk of malaria in women of all gravidities in Kisumu, Kenya AIDS 17 2003 595 603 (Pubitemid 36293113)
R.W. Steketee, B.L. Nahlen, M.E. Parise, and M. Menendez The burden of malaria in pregnancy in malaria-endemic areas. (Review) (70 refs) Am J Trop Med Hyg. 64 2001 28 35 (Pubitemid 32552569)
V. Idemyor Human immunodeficiency virus (HIV) and malaria interaction in sub-Saharan Africa: the collision of two Titans HIV Clin Trials 8 2007 246 253 (Pubitemid 47327462)
OMS. Paludisme et VIH: interactions et répercutions sur les politiques de santé publique. Rapport d'une consultation technique. Genve, Suisse 23-25 juin 2004. http://www.who.int/hiv/en.
J.P. Van geertruyden, and U. D'Alessandro Malaria and HIV-a silent alliance Trends Parasitol. 23 2007 465 467
A. Ayouba, C. Badaut, A. Kfutwah, C. Cannou, A. Juillerat, and S. Gangnard Specific stimulation of HIV-1 replication in human placental trophoblasts by an antigen of Plasmodium falciparum AIDS. 22 2008 785 787 (Pubitemid 351450649)
F.H. Verhoeff, B.J. Brabin, L. Chimsuku, P. Kazembe, W.B. Russell, and R.L. Broadhead An evaluation of the effects of intermittent sulfadoxine- pyrimethamine treatment in pregnancy on parasite clearance and risk of low birth weith in rural Malawi Ann Trop Med Parasitol. 92 1998 141 150 (Pubitemid 28140462)
M.R. Kamya, A.F. Gasasira, A. Yeka, N. Bakyaita, S.L. Nsobya, and D. Francis Effect of HIV-1 infection on antimalarial treatment outcomes in Uganda: a population-based study J Infect Dis. 193 2006 9
S.H. Kapiga, H. Bang, SpiegelmanD, G.I. Msamanga, J. Coley, and D.J. Hunter Corrolates of plasma HIV-1 RNA viral load among HIV-1-seropositive women in Dar es Salaam Tanzania J Acquir Immune Defic Syndr Hum Retrovirol 30 2002 316 323 (Pubitemid 34774080)
I. Inion, F. Mwanyumba, P. Gaillard, V. Chohan, C. Verhofstede, and P. Claeys Placental malaria and perinatal transmission of human immunodeficiency virus type 1 J Infect Dis 188 2003 1675 1678 (Pubitemid 38010678)
V. Mwapasa, RogersonSJ, M.E. Molyneux, E.T. Abrams, D.D. Kamwendo, and V.M. Lema The effect of Plasmodium falciparum malaria on peripheral and placental HIV-1 RNA concentrations in pregnant Malawian women AIDS. 18 2004 1051 1059 (Pubitemid 38591197)
J.G. Ayisi, A.M. van Eijk, R.D. Newman, F.O. ter Kuile, Y.P. Shi, and C. Yang Maternal malaria infection and perinatal HIV transmission in a malarious area of western Kenya Emerg Inf Dis. 10 2004 643 652 (Pubitemid 38420295)
J.G. Kublin, P. Patnaik, C.S. Jere, W.C. Miller, I.F. Hoffman, and N. Chimbiya Effect of plasmodium falciparum malaria on concentration of HIV-1-RNA in the blood of adults in rural Malawi: prospective cohort study Lancet 365 2005 233
H. Brahmbhatt, G. Kigozi, F. Wabwire-Mangen, D. Serwadda, N. Sewankambo, and T. Lutalo The effects of placental malaria on mother-to-child HIV transmission in Rakai, Uganda AIDS. 17 2003 2539 2541 (Pubitemid 38393330)
F.O. ter Kuile, M.E. Parise, F.H. Verhoeff, V. Udhayakumar, R.D. Newman, and A.M. van Eijk The burden of co-infection with human immunodeficiency virus type 1 and malaria in pregnant women in sub-Saharan Africa Am J Trop Med Hyg. 71 2004 41 54 (Pubitemid 39121303)
I.F. Hoffman, C.S. Jere, T.E. Taylor, P. Munthali, J.R. Dyer, and J.J. Wirima The effect of Plasmodium falciparum malaria on HIV-1 RNA blood plasma concentration AIDS 13 1999 487
V. Leroy, J. Ladner, J.E.M. Nyirazira, A. De clercq, A. Bazubagira, and P. van De perre Effect of VIH-1 infection on pregnancy outcome in women in Kigali, Rwanda, 1992-1994 AIDS 12 1998 643 650 (Pubitemid 28162104)
A.M. van Eijk, J.G. Ayisi, F.O. ter Kuile, A. Misore, J.O. Otieno, and M.S. Kolczak Malaria in pregnancy BJOG 112 2005 1189
