[en] Deficits in inhibitory abilities are frequently observed in normal aging and Alzheimer disease (AD). However, few studies have explored the generality of these deficits in a single group of participants. A battery of tasks assessing perceptual and motor inhibitory functioning was administered to young and older healthy participants (Study 1), as well as to mild Alzheimer patients (Study 2). Results did not agree with a selective impairment of motor or perceptual inhibition in either AD or normal aging but rather suggest that a decrease in cognitive resources available in working memory could explain inhibitory performance both in normal aging and AD.
Research center :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège Centre de Neurosciences Cognitives et Comportementales - ULiège
Disciplines :
Neurosciences & behavior
Author, co-author :
Stawarczyk, David ; Université de Liège - ULiège > Département de Psychologie : cognition et comportement > Psychopathologie cognitive
Grandjean, Julien ; Université de Liège - ULiège > Département de Psychologie : cognition et comportement > Neuropsychologie
Salmon, Eric ; Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.
Collette, Fabienne ; Université de Liège - ULiège > Département de Psychologie : cognition et comportement > Neuropsychologie
Language :
English
Title :
Perceptual and motor abilities in normal aging and Alzheimer’s disease: a preliminary study
Publication date :
2012
Journal title :
Archives of Gerontology and Geriatrics
ISSN :
0167-4943
eISSN :
1872-6976
Publisher :
Elsevier Science
Volume :
54
Pages :
e152-e161
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Adam S., Van der Linden M., Collette F., Lemauvais L., Salmon E. Further exploration of controlled and automatic memory processes in early Alzheimer's disease. Neuropsychology 2005, 19:420-427.
Amieva H., Lafont S., Auriacombe S., Le Carret N., Dartigues J.F., Orgogozo J.M. Inhibitory breakdown and dementia of the Alzheimer type: a general phenomenon?. J. Clin. Exp. Neuropsychol. 2002, 24:503-516.
Amieva H., Phillips L.H., Della Sala S., Henry J.D. Inhibitory functioning in Alzheimer's disease. Brain 2004, 127:949-964.
Andres P., Van der Linden M. Age-related differences in supervisory attentional system functions. J. Gerontol. Ser. B, Psychol. Sci. Soc. Sci. 2000, 55:373-380.
Andres P., Guerrini C., Phillips L.H., Perfect T.J. Differential effects of aging on executive and automatic inhibition. Dev. Neuropsychol. 2008, 33:101-123.
Balota D.A., Faust M. Attention in dementia of the Alzheimer's type. Handbook of Neuropsychology 2001, vol. 6. Elsevier Science, Amsterdam, pp. 51-80. second ed.
Belanger S., Belleville S., Gauthier S. Inhibition impairments in Alzheimer's disease, mild cognitive impairment and healthy aging: effect of congruency proportion in a Stroop task. Neuropsychologia 2010, 48:581-590.
Belleville S., Rouleau N., Van der Linden M. Use of the Hayling task to measure inhibition of prepotent responses in normal aging and Alzheimer's disease. Brain Cogn. 2006, 62:113-119.
Bjorklund D.F, Harnishfeger K.K. The evolution of inhibition mechanisms and their role in human cognition and behavior. Interference and Inhibition in Cognition 1995, 141-173. Academic Press, San Diego, CA. F.N. Dempster, C.J. Brainerd (Eds.).
Bondi M.W., Serody A.B., Chan A.S., Eberson-Shumate S.C., Delis D.C., Salmon D.P. Cognitive and neuropathologic correlates of Stroop Color-Word Test performance in Alzheimer's disease. Neuropsychology 2002, 16:335-343.
Buchner A., Mayr S. Auditory negative priming in younger and older adults. Q. J. Exp. Psychol. A, Hum. Exp. Psychol. 2004, 57:769-787.
Butler K.M., Zacks R.T., Henderson J.M. Suppression of reflexive saccades in younger and older adults: age comparisons on an antisaccade task. Mem. Cognit. 1999, 27:584-591.
Collette F., Van der Linden M. Attention disorders in degenerative syndromes. Applied Neuropsychology of Attention: Theory, Diagnosis and Rehabilitation 2002, 305-338. Psychology Press, London. M. Leclercq, P. Zimmerman (Eds.).
Collette F., Van der Linden M., Salmon E. Executive dysfunction in Alzheimer's disease. Cortex 1999, 35:57-72.
Collette F., Amieva H., Adam S., Hogge M., Van der Linden M., Fabrigoule C., Salmon E. Comparison of inhibitory functioning in mild Alzheimer's disease and frontotemporal dementia. Cortex 2007, 43:866-874.
Collette F., Germain S., Hogge M., Van der Linden M. Inhibitory control of memory in normal ageing: dissociation between impaired intentional and preserved unintentional processes. Memory 2009, 17:104-122.
Collette F., Schmidt C., Scherrer C., Adam S., Salmon E. Specificity of inhibitory deficits in normal aging and Alzheimer's disease. Neurobiol. Aging 2009, 30:875-889.
Deltour J.J. Echelle de vocabulaire Mill Hill de J.C. Raven 1993, Editions l'Application des Techniques Modernes, Braine-le-Chateau, Belgium.
Dempster F.N., Corkill A.J. Individual differences in susceptibility to interference and general cognitive ability. Acta Psychol. 1999, 101:395-416.
Dempster F.N., Corkill A.J. Interference and inhibition in cognition and behavior: unifying themes for educational psychology. Educ. Psychol. Rev. 1999, 11:1-88.
Eenshuistra R.M., Ridderinkhof K.R., van der Molen M.W. Age-related changes in antisaccade task performance: inhibitory control or working-memory engagement?. Brain Cogn. 2004, 56:177-188.
Eriksen B.A, Eriksen C.W. Effects of noise letters upon the identification of a target letter in a nonsearch task. Percept. Psychophys. 1974, 16:143-149.
Fabrigoule C., Rouch I., Taberly A., Letenneur L., Commenges D., Mazaux J.M., Orgogozo J.M. Cognitive process in preclinical phase of dementia. Brain 1998, 121:135-141.
Faust M.E., Balota D.A. Inhibition of return and visuospatial attention in healthy older adults and individuals with dementia of the Alzheimer type. Neuropsychology 1997, 11:13-29.
Fernandez-Duque D., Black S.E. Attentional networks in normal aging and Alzheimer's disease. Neuropsychology 2006, 20:133-143.
Gamboz N., Russo R., Fox E. Age differences and the identity negative priming effect: an updated meta-analysis. Psychol. Aging 2002, 17:525-530.
Germain S., Collette F. Dissociation of perceptual and motor inhibitory processes in young and elderly participants using the Simon task. J. Int. Neuropsychol. Soc. 2008, 14:1014-1021.
Gregoire J., Van der Linden M. Effects of age on forward and backward digit spans. Aging Neuropsychol. Cogn. 1997, 4:140-149.
Harnishfeger K.K. The development of cognitive inhibition: theories, definitions, and research evidence. Interference and Inhibition in Cognition 1995, 175-204. Academic Press, San Diego, CA. F.N. Dempster, C.J. Brainerd (Eds.).
Harnishfeger K.K., Bjorklund D.F. The ontogeny of inhibitory mechanisms: a renewed approach to cognitive development. Emerging Themes in Cognitive Development 1993, vol. 1:28-49. Springer-Verlag, New York.
Hartley A.A., Kieley J.M. Adult age differences in the inhibition of return of visual attention. Psychol. Aging 1995, 10:670-683.
Hasher L., Zacks R.T., May C.P. Inhibitory control, circadian arousal, and age. Attention and Performance XVII: Cognitive Regulation of Performance: Interaction of Theory and Application 1999, 653-675. The MIT Press, Cambridge, MA. D. Gopher, A. Koriat (Eds.).
Hasher L., Tonev S.T., Lustig C., Zacks R. Inhibitory control, environmental support, and self-initiated processing in aging. Perspectives on Human Memory and Cognitive Aging. Essays in Honour of Fergus Craik 2001, 286-297. Psychology Press, New York. M. Benjamin, M. Moscovitch, H.L.I. Roediger (Eds.).
Hogge M., Salmon E., Collette F. Interference and negative priming in normal aging and in mild Alzheimer's disease. Psychologica Belgica 2008, 48:1-23.
Houghton G., Tipper S.P. A model of inhibitory mechanisms in selective attention. Inhibitory Processes in Attention, Memory, and Language 1994, 53-112. Academic Press, San Diego, CA. D. Dagenbach, T.H. Carr (Eds.).
Jennings J.R., Mendelson D.N., Redfern M.S., Nebes R.D. Detecting age differences in inhibition processes with a test of perceptual and motor inhibition. Exp. Aging Res. 2011, 37:179-197.
Kane M.J., Hasher L., Stoltzfus E.R., Zacks R.T., Connelly S.L. Inhibitory attentional mechanisms and aging. Psychol. Aging 1994, 9:103-112.
Kensinger E.A, Shearer D.K., Locascio J.J., Growdon J.H., Corkin S. Working memory in mild Alzheimer's disease and early Parkinson's disease. Neuropsychology 2003, 17:230-239.
Kieley J.M., Hartley A.A. Age-related equivalence of identity suppression in the Stroop color-word task. Psychol. Aging 1997, 12:22-29.
Kramer A.F, Humphrey D.G., Larish J.F., Logan G.D., Strayer D.L. Aging and inhibition: beyond a unitary view of inhibitory processing in attention. Psychol. Aging 1994, 9:491-512.
Langley L.K., Overmier J.B., Knopman D.S., Prod'Homme M.M. Inhibition and habituation: preserved mechanisms of attentional selection in aging and Alzheimer's disease. Neuropsychology 1998, 12:353-366.
Langley L.K., Fuentes L.J., Hochhalter A.K., Brandt J., Overmier J.B. Inhibition of return in aging and Alzheimer's disease: performance as a function of task demands and stimulus timing. J. Clin. Exp. Neuropsychol. 2001, 23:431-446.
Logan G.D. On the ability to inhibit thought and action: a users' guide to the stop signal paradigm. Inhibitory Processes in Attention, Memory, and Language 1994, 189-239. Academic Press, San Diego, CA. D. Dagenbach, T.H. Carr (Eds.).
Logan G.D., Cowan W.B., Davis K.A. On the ability to inhibit simple and choice reaction time responses: a model and a method. J. Exp. Psychol. Hum. Percept. Perform. 1984, 10:276-291.
Mattis S. Dementia Rating Scale 1973, NFER-Nelson, Windsor.
May C.P., Hasher L. Synchrony effects in inhibitory control over thought and action. J. Exp. Psychol. Hum. Percept. Perform. 1998, 24:363-379.
McDowd J.M., Oseas-Kreger D.M. Aging, inhibitory processes, and negative priming. J. Gerontol. 1991, 46:340-345.
McKhann G., Drachman D., Folstein M., Katzman R., Price D., Stadlan E.M. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984, 34:939-944.
Nassauer K.W., Halperin J.M. Dissociation of perceptual and motor inhibition processes through the use of novel computerized conflict tasks. J. Int. Neuropsychol. Soc. 2003, 9:25-30.
Nielson K.A., Langenecker S.A., Garavan H. Differences in the functional neuroanatomy of inhibitory control across the adult life span. Psychol. Aging 2002, 17:56-71.
Nigg J.T. On inhibition/disinhibition in developmental psychopathology: views from cognitive and personality psychology and a working inhibition taxonomy. Psychol. Bull. 2000, 126:220-246.
Orsini A., Chiacchio L., Cinque M., Cocchiaro C., Schiappa O., Grossi D. Effects of age, education and sex on two tests of immediate memory: a study of normal subjects from 20 to 99 years of age. Percept. Mot. Skills 1986, 63:727-732.
Roberts R.J., Pennington B.F. An interactive framework for examining prefrontal cognitive processes. Dev. Neuropsychol. 1996, 12:105-126.
Roberts R.J., Hager L.D., Heron C. Prefrontal cognitive processes: working memory and inhibition in the antisaccade task. J. Exp. Psychol. Gen. 1994, 123:374-393.
Salthouse T.A., Becker J.T. Independent effects of Alzheimer's disease on neuropsychological functioning. Neuropsychology 1998, 12:242-252.
Schneider W., Eschman A., Zuccolotto A. E-Prime User's Guide 2002, Psychology Software Tools Inc., Pittsburgh, PA.
Sergeant J. A theory of attention: an information processing perspective. Attention, Memory, and Executive Function 1996, 57-69. Paul H Brookes Publishing, Baltimore, MD. G.R. Lyon, N.A. Krasnegor (Eds.).
Sergeant J., van der Meere J. Additive factor method applied to psychopathology with special reference to childhood hyperactivity. Acta Psychol. 1990, 74:277-295.
Spieler D.H., Balota D.A., Faust M.E. Stroop performance in healthy younger and older adults and in individuals with dementia of the Alzheimer's type. J. Exp. Psychol. Hum. Percept. Perform. 1996, 22:461-479.
Stroop J. Studies of interference in serial verbal reactions. J. Exp. Psychol. 1935, 18:643-662.
Tipper S.P. The negative priming effect: inhibitory priming by ignored objects. Q. J. Exp. Psychol. A, Hum. Exp. Psychol. 1985, 37:571-590.
Wilson S.P., Harnishfeger K.K. The development of efficient inhibition: evidence from directed-forgetting tasks. Dev. Rev. 1998, 18:86-123.
Witthoft M., Sander N., Suss H.M., Wittmann W.W. Adult age differences in inhibitory processes and their predictive validity for fluid intelligence. Neuropsychol. Dev. Cogn. Sect B, Aging Neuropsychol. Cogn. 2009, 16:133-163.
Wodka E.L., Simmonds D.J., Mahone E., Mostofsky S.H. Moderate variability in stimulus presentation improves motor response control. J. Clin. Exp. Neuropsychol. 2009, 31:483-488.
Zimmerman P., Fimm B. Tests d'évaluation de l'attention (TEA) 1994, Psytest, Würselen, Deutschland.