[en] The NEO-Five-Factor Inventory divides human personality traits into five dimensions: neuroticism,
extraversion, openness, conscientiousness and agreeableness. In this study, we sought to identify
regions harboring genes with large effects on the five NEO personality traits by performing
genome-wide linkage analysis of individuals scoring in the extremes of these traits ( > 90th
percentile). Affected-only linkage analysis was performed using an Illumina 6K linkage array
in a family-based study, the Erasmus Rucphen Family study. We subsequently determined
whether distinct, segregating haplotypes found with linkage analysis were associated with the
trait of interest in the population. Finally, a dense single-nucleotide polymorphism genotyping
array (Illumina 318K) was used to search for copy number variations (CNVs) in the associated
regions. In the families with extreme phenotype scores, we found significant evidence of
linkage for conscientiousness to 20p13 (rs1434789, log of odds (LOD) = 5.86) and suggestive
evidence of linkage (LOD > 2.8) for neuroticism to 19q, 21q and 22q, extraversion to 1p, 1q, 9p
and12q, openness to 12q and 19q, and agreeableness to 2p, 6q, 17q and 21q. Further analysis
determined haplotypes in 21q22 for neuroticism (P-values = 0.009, 0.007), in 17q24 for
agreeableness (marginal P-value = 0.018) and in 20p13 for conscientiousness (marginal
P-values = 0.058, 0.038) segregating in families with large contributions to the LOD scores.
No evidence for CNVs in any of the associated regions was found. Our findings imply that
there may be genes with relatively large effects involved in personality traits, which may be
identified with next-generation sequencing techniques.
Disciplines :
Psychiatry
Author, co-author :
Amin, Najaf; Erasmus University Medical Center, Rotterdam, The Netherlands > Department of Epidemiology
Schuur, M.; Erasmus University Medical Center, Rotterdam, The Netherlands > Department of Epidemiology
Gusareva, Elena ; Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Bioinformatique
Isaacs, Aaron; Erasmus University Medical Center, Rotterdam, The Netherlands > Department of Epidemiology
Aulchenko, Yuri; Erasmus University Medical Center, Rotterdam, The Netherlands > Department of Epidemiology
Kirichenko, A. V.; Institute of Cytology and Genetics, Russian Academy of Science, Novosibirsk, Russia
Zorkoltseva, I. V.; Institute of Cytology and Genetics, Russian Academy of Science, Novosibirsk, Russia
Axenovich, Tatyana; Novosibirsk State University, Novosibirsk, Russia > Department of Cytology and Genetics
Oostra, B. A.; Erasmus University Medical Center, Rotterdam, The Netherlands > Department of Epidemiology
Janssens, ACJW; Erasmus University Medical Center, Rotterdam, The Netherlands > Department of Epidemiology
van Duijn, Cornelia M; Erasmus University Medical Center, Rotterdam, The Netherlands > Department of Epidemiology
Language :
English
Title :
A genome-wide linkage study of individuals with high scores on NEO personality traits
Publication date :
09 August 2011
Journal title :
Molecular Psychiatry
ISSN :
1359-4184
eISSN :
1476-5578
Publisher :
Nature Publishing Group, Houndmills, United Kingdom
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