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15 January 2012
Article (Scientific journals)
Milestones on Steroids and the Nervous System: 10 Years of Basic and Translational Research.
Panzica, G. C.; Balthazart, Jacques  ; Frye, C. A. et al.
2012 • In Journal of Neuroendocrinology, 24 (1), p. 1-15
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Abstract :
[en] During the last 10 years, the conference on 'Steroids and Nervous System' held in Torino (Italy) has been an important international point of discussion for scientists involved in this exciting and expanding research field. The present review aims to recapitulate the main topics that have been presented through the various meetings. Two broad areas have been explored: the impact of gonadal hormones on brain circuits and behaviour, as well as the mechanism of action of neuroactive steroids. Relationships among steroids, brain and behaviour, the sexual differentiation of the brain and the impact of gonadal hormones, the interactions of exogenous steroidal molecules (endocrine disrupters) with neural circuits and behaviour, and how gonadal steroids modulate the behaviour of gonadotrophin-releasing hormone neurones, have been the topics of several lectures and symposia during this series of meetings. At the same time, many contributions have been dedicated to the biosynthetic pathways, the physiopathological relevance of neurosteroids, the demonstration of the cellular localisation of different enzymes involved in neurosteroidogenesis, the mechanisms by which steroids may exert some of their effects, both the classical and nonclassical actions of different steroids, the role of neuroactive steroids on neurodegeneration, neuroprotection, and the response of the neural tissue to injury. In these 10 years, this field has significantly advanced and neuroactive steroids have emerged as new potential therapeutic tools to counteract neurodegenerative events.
Disciplines :
Neurosciences & behavior
Author, co-author :
Panzica, G. C.
Balthazart, Jacques ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau
Frye, C. A.
Garcia-Segura, L. M.
Herbison, A. E.
Mensah-Nyagan, A. G.
McCarthy, M. M.
Melcangi, R. C.
Language :
Title :
Milestones on Steroids and the Nervous System: 10 Years of Basic and Translational Research.
Publication date :
Journal title :
Journal of Neuroendocrinology
Publisher :
Blackwell Publishing, Oxford, United Kingdom
Volume :
Issue :
Pages :
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
(c) 2011 The Authors. Journal of Neuroendocrinology (c) 2011 Blackwell Publishing Ltd.


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