Reference : Computational toxicology: Physiologically based pharmacokinetic models (PBPK) for lif...
Scientific journals : Article
Life sciences : Environmental sciences & ecology
Life sciences : Aquatic sciences & oceanology
Computational toxicology: Physiologically based pharmacokinetic models (PBPK) for lifetime exposure and bioaccumulation of polybrominated dephenyl ethers (PBDEs) in marine mammals
Weijs, Liesbeth [> >]
Covaci, Adrian [> >]
Yang, Raymond S H [> >]
Das, Krishna mailto [Université de Liège - ULiège > Département de Biologie, Ecologie et Evolution > Océanologie >]
Blust, Ronny [> >]
Environmental Pollution
Elsevier Science
Yes (verified by ORBi)
United Kingdom
[en] marine mammals ; pollution ; harbour porpoise ; Phocoena phocoena ; PBPK models ; PBDEs ; time trends ; Black Sea ; North Sea
[en] Due to migration of harbour porpoises towards more polluted areas like the North Sea and their sensitivity towards pollution, there is a need for proper conservation measures for this species. As a consequence, knowledge about the pollutant’s kinetics is required. The present study is the first to investigate the kinetics of PBDEs in marine mammals using PBPK modeling as a non-destructive tool for describing the chemical’s kinetics in a protected animal species. The models were developed and parameterized using data from the literature and Black Sea harbour porpoises through computer opti- mization. The predictability of these models in time was assessed by reverse dosimetry modeling using data from North Sea porpoises (1990e2008). From these predictions, PBDE 99 levels were found to decrease the fastest, followed by PBDE 153, 47 and 100. Results show that the PBPK models can be applied for harbour porpoises from different regions and also simulate time trends.
Fonds Wetenschappelijk Onderzoek - FWO ; Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS

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