Results of kidney transplantation from controlled donors after cardio-circulatory death: a single center experience.

[en] The aim of this study was to determine results of kidney transplantation (KT) from controlled donation after cardio-circulatory death (DCD). Primary end-points were graft and patient survival, and post-transplant complications. The influence of delayed graft function (DGF) on graft survival and DGF risk factors were analyzed as secondary end-points. This is a retrospective mono-center review of a consecutive series of 59 DCD-KT performed between 2005 and 2010. Overall graft survival was 96.6%, 94.6%, and 90.7% at 3 months, 1 and 3 years, respectively. Main cause of graft loss was patient's death with a functioning graft. No primary nonfunction grafts. Renal graft function was suboptimal at hospital discharge, but nearly normalized at 3 months. DGF was observed in 45.6% of all DCD-KT. DGF significantly increased postoperative length of hospitalization, but had no deleterious impact on graft function or survival. Donor body mass index >/=30 was the only donor factor that was found to significantly increase the risk of DGF (P < 0.05). Despite a higher rate of DGF, controlled DCD-KT offers a valuable contribution to the pool of deceased donor kidney grafts, with comparable mid-term results to those procured after brain death.

Disciplines :

Urology & nephrology
Anesthesia & intensive care
Surgery

Author, co-author :

Ledinh, H.

WEEKERS, Laurent ; Centre Hospitalier Universitaire de Liège - CHU > Néphrologie

BONVOISIN, Catherine ; Centre Hospitalier Universitaire de Liège - CHU > Néphrologie

Krzesinski, Jean-Marie ; Université de Liège - ULiège > Département des sciences cliniques > Néphrologie

MONARD, Josée ; Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdominale- endocrinienne et de transplantation

DE ROOVER, Arnaud ; Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdominale- endocrinienne et de transplantation

SQUIFFLET, Jean-Paul ; Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdominale- endocrinienne et de transplantation

Meurisse, Michel ; Université de Liège - ULiège > Département des sciences cliniques > Chirurgicale abdominale

DETRY, Olivier ; Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdominale- endocrinienne et de transplantation

Language :

English

Title :

Results of kidney transplantation from controlled donors after cardio-circulatory death: a single center experience.

Publication date :

February 2012

Journal title :

Transplant International

ISSN :

0934-0874

eISSN :

1432-2277

Publisher :

Springer International, Heidelberg, Germany

Volume :

Pages :

201-209

Peer reviewed :

Peer Reviewed verified by ORBi

Commentary :

Transplant International (c) Michel Meurisse.

Available on ORBi :

since 10 January 2012

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