Reference : First study of oral artenimol-R in advanced cervical cancer: clinical benefit, tolera...
Scientific journals : Article
Human health sciences : Oncology
First study of oral artenimol-R in advanced cervical cancer: clinical benefit, tolerability and tumor markers
Jansen, Frans Herwig mailto [ > > ]
Adoubi, Innocent [ > > ]
Kouassi, Comoe J.C. [ > > ]
De Cnodder, Tine [ > > ]
JANSEN, Nicolas mailto [Centre Hospitalier Universitaire de Liège - CHU > > Radiothérapie >]
Tschulakow, Alexander [ > > ]
Efferth, Thomas [ > > ]
Anticancer Research
JG Delinassios Anticancer Research
Yes (verified by ORBi)
[en] cervical cancer ; artesunate ; artenimol ; clinical symptoms ; tumor markers
[en] Background/Aim: Artenimol-R is cytotoxic in transformed cervical cells and safety in humans is yet to be established. The present study investigates the clinical benefits, safety and the tumor marker effect of orally administered Artenimol-R in patients with advanced cervix carcinoma. Patients and Methods: Ten patients were treated with Artenimol-R for 28 days. Clinical symptoms, vaginal discharge and pain were followed-up. Adverse events were recorded. Biopsy samples were analyzed by immunohistochemistry for the expression of relevant tumor markers. Results: Artenimol-R treatment induced clinical remission with a median time for the disappearance of the symptoms being 7 days. No adverse events of grade 3 or 4 occurred. The expression of p53, Epidermal growth factor receptor (EGFR), and antigen Ki-67 as a cellular marker of proliferation, as well as the number of blood vessels stained by the CD31 antibody decreased, whereas the expression of transferrin receptor protein 1 (CD71) increased. Conclusion: The current pilot study provides evidence on the improvement of the clinical symptoms and the good tolerability of Artenimol-R in patients with advanced carcinoma of the cervix uteri. A survival trial with Artenimol- R in advanced patients is warranted.

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