Evaluation de l'insulinosecretion et de l'insulinosensibilite

Animals; Diabetes Mellitus, Type 2/physiopathology; Glucose Clamp Technique; Homeostasis/drug effects/physiology; Humans; Hypoglycemic Agents/pharmacology; Insulin/physiology/secretion; Insulin Resistance/physiology

Abstract :

[en] Insulin secretion and insulin sensitivity interact in concert to maintain glucose homeostasis. Various pathologies, especially type 2 diabetes, are characterized by defects in secretion and/or action of insulin and numerous drugs are able to partially correct these two defects. Therefore, the assessment of insulin secretion and insulin sensitivity is of interest to guide the choice of pharmacological treatments and to evaluate their efficacy. It could be performed by studying the couple of fasting insulin/glucose plasma concentrations or by performing dynamic tests, which mainly use the administration of glucose. The intimate relationship between insulin secretion and insulin sensitivity requires either appropriate tests that open the homeostatic feedback loop ("glucose clamp"), or sophisticated modeling approaches ("HOMA", "minimal model"). Insulin secretion should ideally be measured according to the corresponding insulin sensitivity. Dynamic tests are generally more informative than static measurements in the fasting state.

Disciplines :

Endocrinology, metabolism & nutrition

Author, co-author :

Scheen, André ; Université de Liège - ULiège > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale

Language :

French

Title :

Evaluation de l'insulinosecretion et de l'insulinosensibilite

Alternative titles :

[en] Evaluation of insulinosecretion and insulinosensitivity

Publication date :

2007

Journal title :

Thérapie

ISSN :

0040-5957

Publisher :

EDP Sciences, Les Ulis, France

Volume :

Issue :

Pages :

311-8

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 08 April 2009

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6404 (33 by ULiège)

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