Reference : Native and recombinant bovine placental lactogens.
Scientific journals : Article
Life sciences : Veterinary medicine & animal health
Native and recombinant bovine placental lactogens.
Alvarez Oxiley, Andrea Vivian [Université de Liège - ULiège > > > Doct. sc. vété. (Bologne)]
Melo de Sousa, Noelita mailto [Université de Liège - ULiège > Département de sciences fonctionnelles > Physiologie de la reproduction >]
Beckers, Jean-François mailto [Université de Liège - ULiège > Département de sciences fonctionnelles > Physiologie de la reproduction >]
Reproductive Biology
Yes (verified by ORBi)
[en] Cow ; Glycosylation ; Native ; Recombinant ; Placental lactogen
[en] The bovine placenta produces a wide variety of proteins that are structurally and functionally similar to the pituitary proteins from the GH/PRL gene family. Bovine placental lactogen (bPL) is a 200-amino acid long glycoprotein hormone that exhibits both lactogenic and somatogenic properties. The apparent molecular masses of purified native (n) bPL molecules (31-33 kDa) exceed 23 041 Da, which is the theoretical molecular mass of the protein core. At least six isoelectric variants (pI: 4.85-6.3) of bPL were described in cotyledonary extracts and three different bPL isoforms (pI: 4.85-5.25) were found in fetal sera. The bPL molecules that are detected in higher concentrations in peripheral circulation exhibit a more acidic pI than those present in placental homogenates. This may reflect an important glycosylation process occurring just prior to the bPL secretion. The bPL mRNA is transcribed in trophectoderm binucleate cells starting from Day 30 of pregnancy until the end of gestation. In mothers, bPL is involved in the regulation of ovarian function, mammogenesis, lactogenesis, and pregnancy stage-dependent adaptation of nutrient supplies to the fetus. Due to the higher fetal, compared to maternal concentrations of circulating hormone, it has been suggested that bPL primarily targets fetal tissues.
Researchers ; Professionals ; Students

File(s) associated to this reference

Fulltext file(s):

Restricted access
AlvarezAV_ReprodBiol_2008.pdfPublisher postprint633.24 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.