Reference : L'etude clinique du mois. L'etude LIPS: prevention par la fluvastatine des accidents ...
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
Human health sciences : Cardiovascular & respiratory systems
L'etude clinique du mois. L'etude LIPS: prevention par la fluvastatine des accidents cardiaques apres angioplastie coronaire percutanee.
[en] Clinical study of the month. The LIPS study: fluvastatin for prevention of cardiac events following percutaneous coronary angioplasty
Scheen, André mailto [Université de Liège - ULiège > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale >]
Revue Médicale de Liège
Yes (verified by ORBi)
[en] Adolescent ; Adult ; Aged ; Aged, 80 and over ; Angioplasty, Balloon/adverse effects ; Anticholesteremic Agents/pharmacology/therapeutic use ; Coronary Artery Disease/surgery ; Fatty Acids, Monounsaturated/pharmacology/therapeutic use ; Female ; Humans ; Hypercholesterolemia/complications ; Indoles/pharmacology/therapeutic use ; Male ; Middle Aged ; Myocardial Infarction/prevention & control ; Placebos ; Postoperative Complications/prevention & control ; Prospective Studies
[en] The prospective placebo-controlled LIPS study ("Lescol Intervention Prevention Study") demonstrated a significant cardiovascular protection by fluvastatin in patients with coronary artery disease (stable or unstable angina, silent ischemia), without major hypercholesterolaemia (135-270 mg/dl) following successful completion of their first percutaneous coronary intervention. When compared to the placebo group (n = 833), the fluvastatin group (n = 844) showed a relative risk reduction by 22% (relative risk: 0.78; 95% confidence interval: 0.64-0.95; p = 0.01) of major adverse cardiac events after a median time of follow-up of 3.9 years. This effect is observed independently of baseline total cholesterol, of the presence of diabetes mellitus or the existence of multivessel disease. These results suggest that fluvastatin may favorably influence the restenosis process after percutaneous coronary intervention, even in the absence of severe hypercholesterolaemia.
Researchers ; Professionals ; Students

File(s) associated to this reference

Fulltext file(s):

Open access
20020708_12.pdfNo commentaryPublisher postprint432.26 kBView/Open

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.