Evidence-Based Medicine/methods; Meta-Analysis as Topic
Abstract :
[en] Meta-analysis is becoming a key partner of Evidence-Based Medicine. This statistical tool is currently used in most systematic reviews and allows to quantitatively synthesize the results of several studies by a single weighted average whose precision is indicated by the confidence interval. A standardized graphical representation allows, at first glance, to derive a lot of useful information, especially the number of studies taken into account for the analysis, the mean effect observed in each study with its confidence interval, the relative size (number of subjects) of each study, the homogeneity/heterogeneity of between-study results, finally the overall mean effects with its confidence interval. The meta-analysis plays a key-role in epidemiology, for the evaluation of a risk or a protective factor, and in therapeutics, for summarizing the results of numerous clinical trials with a specific drug or a pharmacological class in a given disease.
Disciplines :
General & internal medicine
Author, co-author :
Scheen, André ; Université de Liège - ULiège > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale
Language :
French
Title :
Comment j'explore ... les secrets d'une meta-analyse.
Alternative titles :
[en] How I explore...the secrets of a meta-analysis
Publication date :
2003
Journal title :
Revue Médicale de Liège
ISSN :
0370-629X
eISSN :
2566-1566
Publisher :
Université de Liège. Revue Médicale de Liège, Liège, Belgium
Numéraux spéciaux. - De la médecine factuelle aux recommandations thérapeutiques. Rev Med Liège, 2000, 55, 201-479.
Guyatt G, Rennie D (Eds). - Users' guides to the medical literature. A manual for evidence-based clinical practice. The Evidence-Based Medicine Working Group, AMA Press, Chicago, USA, 2002, 706p.
Scheen AJ. - La Cochrane Collaboration, porte-parole de la médecine factuelle. Rev Med Liège, 2001, 56, 796-798.
Sacks HS, Berrier J, Reitman D, et al. - Meta-analyses of randomised clinical trials. N Engl J Med, 1987, 316, 450-455.
L'Abbe KA, Detsky AS, O'Rourke K. - Meta-analysis in clinical research. Ann Intern Med, 1987, 107, 224-233.
Boissel JP, Blanchard J, Panake E, et al. - Considerations for the meta-analysis of randomised clinical trials. Summary of a panel discussion. Control Clin Trials, 1989, 10, 254-281.
Crowley P, Chahners I, Keirse MJNC. - The effects of corticosteroid administration before preterm delivery: an overview of the evidence from controlled trials. Br J Obstet Gynaecol, 1990, 97, 11-25.
Egger M, Smith GD. - Meta-analysis. Potentials and promise. BMJ, 1997, 315, 1371-1374.
Boissel JP. - Les avantages de la méta-analyse des essais cliniques. Thérapie, 1994, 50, 161-164.
Durand DV. - Problèmes soulevés par la réalisation et l'interprétation des méta-analyses. Thérapie, 1994, 50, 165-168.
Cucherat M. - Méta-analyses des essais thérapeutiques. Masson, Paris, Evaluation et statistiques, 1997, 390 p.
Bossard N, Landais P, Thalabard JC. - La démarche méta-analytique. Concepts méthododogiques généraux. Méd & Thér, 1998, 4, 617-625.
Bossard N, Landais P, Thalabard JC. - La démarche méta-analytique. Réflexion sur les méthodes. Méd & Thér, 1998, 4, 626-631.
Glass GV. - Primary, secondary and meta-analysis of research. Educ Res, 1976, 5, 3-8.
Reginster JY, Betz R. - Evidence-based medicine. Apport des études épidémiologiques. Rev Med Liège, 2000, 55, 211-215.
Scheen AJ. - Evidence-based medicine. Apport des essais cliniques contrôlés. Rev Med Liège, 2000, 55, 216-219.
Feinstein AR. - Meta-analysis: statistical alchemy for the 21st century. J Clin Epidemiol, 1995, 48, 71-79.
LeLorier J, Gregoire G, Benhaddad A, et al. - Discrepancies between meta-analyses and subsequent large randomized, controlled trials. N Engl J Med, 1997, 337, 536-542.
Egger M, Smith GD, Schneider M, Minder C. - Bias in meta-analysis detected by a simple, graphical test. BMJ, 1997, 315, 629-634.
Cook DJ, Guyatt GH, Ryan G, et al. - Should unpublished data be included in meta-analyses? Current convictions and controversies. JAMA, 1993, 269, 2749-2753.
Scheen AJ. - Comment je traite ... L'homéopathie peutelle trouver sa légitimité dans les résultats "positifs" d'une méta-analyse? Rev Med Liège, 1997, 52, 694-697.
Scheen AJ. - La mesure de l'efficacité thérapeutique, étape essentielle dans la médecine factuelle. Rev Med Liège, 2000, 55, 206-210.
Lewis S, Clarke M. - Forest plots: trying to see the wood and the trees. BMJ, 2001, 322, 1479-1480.
Eysenck HJ. - Problems with meta-analysis, in Systematic reviews (Chalmers I, Altman DG, Eds). BMJ Publishing Group, London, 1995, 64-74.
Similar publications
Sorry the service is unavailable at the moment. Please try again later.
This website uses cookies to improve user experience. Read more
Save & Close
Accept all
Decline all
Show detailsHide details
Cookie declaration
About cookies
Strictly necessary
Performance
Strictly necessary cookies allow core website functionality such as user login and account management. The website cannot be used properly without strictly necessary cookies.
This cookie is used by Cookie-Script.com service to remember visitor cookie consent preferences. It is necessary for Cookie-Script.com cookie banner to work properly.
Performance cookies are used to see how visitors use the website, eg. analytics cookies. Those cookies cannot be used to directly identify a certain visitor.
Used to store the attribution information, the referrer initially used to visit the website
Cookies are small text files that are placed on your computer by websites that you visit. Websites use cookies to help users navigate efficiently and perform certain functions. Cookies that are required for the website to operate properly are allowed to be set without your permission. All other cookies need to be approved before they can be set in the browser.
You can change your consent to cookie usage at any time on our Privacy Policy page.
