Early activation of cardiac and renal endothelin systems in experimental heart failure

[en] We investigated the time course of the expression of cardiac and renal endothelin systems in tachycardia-induced heart failure in dogs. Eleven beagles underwent rapid pacing at a progressively increased rate over a period of 5 wk, with a weekly clinical examination, echocardiography, measurement of circulating and urinary endothelin-1 (ET-1), and myocardial and renal tissue biopsies. Real-time quantitative PCR was used for determinations of tissue prepro-ET-1 (ppET-1), ET-1-converting enzyme (ECE-1), and ETA and ETB receptor mRNA. Cardiac and renal tissue ET-1 contents were evaluated by immunostaining and measured by radioimmunoassay at autopsy. Rapid pacing caused a progressive increase in end-systolic and end-diastolic ventricular volumes (P<0.05) from week 2 together with a decrease in ejection fraction and in mean velocity of circumferential shortening (P<0.05) from week 1. These changes were tightly correlated to myocardial ppET-1 and renal ETA receptor mRNA and less so to myocardial ECE-1 mRNA, and they occurred before any increase in plasma and urinary ET-1 (P<0.05 from week 4) and clinical signs of heart failure. Renal ppET-1 did not change. Both cardiac and renal ET-1 peptide contents were increased at autopsy. We conclude that tachycardia-induced heart failure in dogs is characterized by an early activation of the cardiac and renal tissue endothelin systems, which occurs before any changes in circulating and urinary ET-1 and is closely related to altered ventricular function.

Disciplines :

Cardiovascular & respiratory systems
Anatomy (cytology, histology, embryology...) & physiology

Author, co-author :

Motte, S.

van Beneden, R.

Mottet, J.

Rondelet, B.

Mathieu, M.

Havaux, X.

Lause, P.

Clercx, Cécile ; Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Pathologie médicale des petits animaux

Ketelslegers, J. M.

Naeije, R.

Mc Entee, Kathleen ; Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Sémiologie et clinique médicale des petits animaux

Language :

English

Title :

Early activation of cardiac and renal endothelin systems in experimental heart failure

Publication date :

01 December 2003

Journal title :

American Journal of Physiology - Heart and Circulatory Physiology

ISSN :

0363-6135

eISSN :

1522-1539

Publisher :

Amer Physiological Soc, Bethesda, United States - Maryland

Volume :

285

Issue :

Pages :

H2482-H2491

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 07 December 2011

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