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Prevention cardio-vasculaire par les statines: faut-il encore doser le cholesterol?

Scheen, André; Kulbertus, Henri

2003 • In Revue Médicale de Liège, 58 (4), p. 191-7

Peer reviewed

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https://hdl.handle.net/2268/10458

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12868320

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Keywords :

Cardiovascular Diseases/prevention & control; Clinical Trials as Topic; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use; Hypercholesterolemia/drug therapy; Risk Factors

Abstract :

[en] Statins, the most popular lipid-lowering agents, have proven their efficacy in preventing cardiovascular events in subjects with lower and lower initial plasma cholesterol levels. Besides, the protective effect does not seem to be directly related neither to the degree of the cholesterol reduction nor to the final level of plasma cholesterol level reached under treatment. Such observations suggest that statins may exert vascular protective effects, at least in part, independently of their specific cholesterol-lowering effect (so-called pleiotropic effects). The present paper will discuss the arguments pro and contra the dosage of cholesterolaemia before initiating a therapy with statin and during treatment follow up, both in subjects with previous cardiovascular events (secondary prevention) and in subjects with a high cardiovascular absolute risk but without previous clinical expression of atherosclerosis (primary prevention).

Disciplines :

Pharmacy, pharmacology & toxicology
Cardiovascular & respiratory systems

Author, co-author :

Scheen, André ; Université de Liège - ULiège > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale

Kulbertus, Henri ; Université de Liège - ULiège > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine)

Language :

French

Title :

Prevention cardio-vasculaire par les statines: faut-il encore doser le cholesterol?

Alternative titles :

[en] Statins for cardiovascular prevention: is there still a place for cholesterol measurement?

Publication date :

2003

Journal title :

Revue Médicale de Liège

ISSN :

0370-629X

eISSN :

2566-1566

Publisher :

Université de Liège. Revue Médicale de Liège, Liège, Belgium

Volume :

58

Issue :

4

Pages :

191-7

Peer reviewed :

Peer reviewed

Additional URL :

http://www.rmlg.ulg.ac.be

Available on ORBi :

since 07 April 2009

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Scopus citations^®

21

Scopus citations^®
without self-citations

0

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