Article (Scientific journals)
Comparative study of dichlorodiphenyldichloroethylene in blood and semen of two young male populations: Lack of relationship to infertility, but evidence of high exposure of the mothers
Charlier, Corinne; Foidart, Jean-Michel
2005In Reproductive Toxicology, 20 (2, Jul-Aug), p. 215-220
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Keywords :
dichlorodiphenyldichloroethylene; hypofertility; mother exposure; semen quality; xenoestrogens
Abstract :
[en] The purpose of the study was to investigate the possible effect of an environmental organochlorine, dichlorodiphenyldichloroethylene (p,p'-DDE), on male fertility assessed by main sperm variables, conducted through a case-control study on young men attending the andrology laboratory in the context of infertility investigation in the couple. Blood and semen samples were obtained from 73 young men considered as fertile based on semen analysis (controls) and 82 classified as subfertile or unfertile (cases). Standard clinical analysis of semen was performed and identification and quantification of p,p'-DDE in serum and in seminal plasma were done by gas chromatography. No p,p'-DDE was detected in the seminal plasma of either group. Blood concentration of p,p'-DDE in both groups was very low and did not differ between cases and controls; however, blood samples were obtained from 23 mothers in the control group, and from 19 in the case group, and p,p'-DDE serum level was significantly higher in the mothers of subfertile men. These data suggest that male infertility could be associated with exposure of the mothers to p,p'-DDE with deleterious effects restricted to intra-uterine life and thus undetected in blood or seminal plasma of subfertile men.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Charlier, Corinne  ;  Université de Liège - ULiège > Département de pharmacie > Chimie toxicologique
Foidart, Jean-Michel ;  Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique
Language :
English
Title :
Comparative study of dichlorodiphenyldichloroethylene in blood and semen of two young male populations: Lack of relationship to infertility, but evidence of high exposure of the mothers
Publication date :
2005
Journal title :
Reproductive Toxicology
ISSN :
0890-6238
eISSN :
1873-1708
Publisher :
Pergamon In Cooperation With the Reproductive Toxicology Center, Elmsford, United States - New York
Volume :
20
Issue :
2, Jul-Aug
Pages :
215-220
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 07 April 2009

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