Comparative study of dichlorodiphenyldichloroethylene in blood and semen of two young male populations: Lack of relationship to infertility, but evidence of high exposure of the mothers
Charlier, Corinne; Foidart, Jean-Michel
2005 • In Reproductive Toxicology, 20 (2, Jul-Aug), p. 215-220
[en] The purpose of the study was to investigate the possible effect of an environmental organochlorine, dichlorodiphenyldichloroethylene (p,p'-DDE), on male fertility assessed by main sperm variables, conducted through a case-control study on young men attending the andrology laboratory in the context of infertility investigation in the couple. Blood and semen samples were obtained from 73 young men considered as fertile based on semen analysis (controls) and 82 classified as subfertile or unfertile (cases). Standard clinical analysis of semen was performed and identification and quantification of p,p'-DDE in serum and in seminal plasma were done by gas chromatography. No p,p'-DDE was detected in the seminal plasma of either group. Blood concentration of p,p'-DDE in both groups was very low and did not differ between cases and controls; however, blood samples were obtained from 23 mothers in the control group, and from 19 in the case group, and p,p'-DDE serum level was significantly higher in the mothers of subfertile men. These data suggest that male infertility could be associated with exposure of the mothers to p,p'-DDE with deleterious effects restricted to intra-uterine life and thus undetected in blood or seminal plasma of subfertile men.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Charlier, Corinne ; Université de Liège - ULiège > Département de pharmacie > Chimie toxicologique
Foidart, Jean-Michel ; Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique
Language :
English
Title :
Comparative study of dichlorodiphenyldichloroethylene in blood and semen of two young male populations: Lack of relationship to infertility, but evidence of high exposure of the mothers
Publication date :
2005
Journal title :
Reproductive Toxicology
ISSN :
0890-6238
eISSN :
1873-1708
Publisher :
Pergamon In Cooperation With the Reproductive Toxicology Center, Elmsford, United States - New York
E. Carlsen, A. Giwercman, N. Keiding, and N.E. Skakkebaek Evidence for decreasing quality of semen during past 50 years Br Med J 305 1992 609 613
A. Oliva, A. Spira, and L. Multigner Contribution of environmental factors to the risk of male infertility Hum Reprod 16 2001 1768 1776
J. Auger, J.M. Kuntsmann, F. Czyglik, and P. Jouannet Decline in semen quality among fertile men in Paris during the past 20 years N Engl J Med 332 1995 281 285
D.S. Irvine Declining sperm quality: a review of facts and hypotheses Baillieres Clin Obst Gynaecol 11 1997 655 671
A. Osterlind Diverging trends in incidence and mortality of testicular cancer in Denmark Br J Cancer 53 1986 153 156
A.E. Giwereman, and N.E. Skakkebaek The human testis: an organ at risk? Int J Androl 15 1992 373 385
G. Bryan, P.E. Gibbs, and L.G. Hummerstone The decline of the gastropod Nucella lapidus around South-West England: evidence for the effect of tributylin from antifouling paints J Mar Biol Ass UK 66 1996 611 640
J. Bitman, H.C. Cecil, S.J. Harris, and G.F. Fries Estrogenic activity of o,p′-DDT in the mammalian uterus and avian oviduct Science 162 1968 371 372
T. Andersson, L. Forlin, and I. Harig Physiological disturbances in fish living in coastal water polluted with bleached kraft mill effluents Can J Fish Aqua Sci 45 1998 1525 1536
C.F. Facemire, T.S. Gross, and L.J. Guillette Reproductive impairment in the Florida panther: nature or nurture Environ Health Perspect 103 Suppl. 4 1995 174 188
R.M. Sharpe Declining sperm counts in men: is there an endocrine cause? J Endocrinol 137 1993 357 360
R. Kovacevic, M. Vojïnovic-Miloradov, I. Teodorovic, and S. Andric Effects of PCBs on androgen production by suspension of adult rat Leydig cells in vitro J Steroid Biochem Mol Biol 52 1995 595 597
N. Atanassova, C. McKinnel, and K.J. Turner Comparative effects of neonatal exposure of male rats to potent and weak estrogens on spermatogenesis at puberty and the relationship to adult testis size and fertility: evidence for stimulatory effects of low estrogen levels Endocrinology 141 2000 3898 3907
W.R. Kelce, C.R. Stone, S.C. Laws, L.E. Gray, J.A. Kemppainen, and E.M. Wilson Persistent DDT metabolite p,p′-DDE is a potent androgen receptor antagonist Nature 375 1995 581 585
WHO laboratory manual for examination of human semen and semen-cervical mucus interaction. 3rd ed. Cambridge (UK): Cambridge University Press; 1992.
C. Charlier, and G. Plomteux Determination of organochlorines pesticide residues in blood of healthy individuals Clin Chem Lab Med 40 2002 361 364
R. Rozati, P.P. Reddy, P. Reddanna, and R. Mujtaba Xenoestrogens and male infertility: myth or reality? Asian J Androl 2 2000 263 269
R.M. Sharpe Environment, lifestyle and male infertility Best Pract Res Clin Endocrin Metab 14 2000 489 503
I. Figa-Talamanca, M.E. Traina, and E. Urbani Occupational exposures to metals, solvents and pesticides: recent evidence on male reproductive effects and biological markers Occup Med 51 2001 174 188
M. Krstevska-Konstantinova, C. Charlier, and M. Craen Sexual precocity after immigration from developing countries to Belgium: evidence of previous exposure to organochlorine pesticides Hum Reprod 16 2001 1020 1026
D.M. de Krester Declining sperm count Br Med J 312 1996 457 458
C. Charlier, A. Albert, and P. Herman Breast cancer and serum level of organochlorines residues Occup Environ Med 60 2003 348 351
P. Cocco On the rumors about the silent spring. Review of the scientific evidence linking the occupational and environmental pesticide exposure to endocrine disruption health effects Cad Saùde Pùblica 18 2002 379 402
P. Sohoni, and J.P. Sumpter Several environmental estrogens are also anti-androgens J Endocrinol 158 1998 327 339
L. You, M. Casanova, S. Archibeque-Engle, M. Sar, L.Q. Fan, and H.A. Heck Impaired male sexual development in perinatal Sprague-Dawley and Long Evans hooded rats exposed in utero and lactationnally to p,p′-DDE Toxicol Sci 45 1998 162 173
L.J. Guillette, T.S. Gross, G.R. Masson, J.M. Matter, H.F. Percival, and A.R. Woodward Developmental abnormalities of the gonad and abnormal sex hormone concentrations in juvenile alligators from contaminated and control lakes in Florida Environ Health Perspect 102 1994 680 688
H. Bouwman, R.M. Cooppan, P.J. Becker, and S. Ngxongo Malaria control and levels of DDT in serum of two populations in Kwazulu J Toxicol Environ Health 33 1991 141 155
I. Figa-Talamanca, M.E. Traina, and E. Urbani Occupational exposures to metals, solvents and pesticides: recent evidence on male reproductive effects and biological markers Occup Med 51 2001 174 188
S. Koifman, R.J. Koifman, and A. Meyer Human reproductive system disturbances and pesticide exposure in Brazil Cad Saùde Pùblica 18 2002 435 445
G. Petrelli, and A. Mantovani Environmental risk factors and male fertility and reproduction Contraception 65 2002 297 300
L. Silvestroni, and S. Palleschi Effects of organochlorine xenobiotics on human spermatozoa Chemosphere 39 1999 1249 1252
F. Eertman, W. Dhooge, S. Stuyvaert, and F. Comhaire Endocrine disruptors: effects on male fertility and screening tools for their assessment Toxicol In Vitro 17 2003 515 524
