Article (Scientific journals)
Viral expression directs the fate of B cells in BLV-infected sheep.
Florins, Arnaud-Francois; De Brogniez, Alix; Elemans, M. et al.
2012In Journal of Virology, 86 (1), p. 621-624
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Abstract :
[en] The host immune response is believed to tightly control viral replication of deltaretroviruses such as human T-lymphotropic virus type 1 (HTLV-1) and bovine leukemia virus (BLV). However, this assumption has not been definitely proven in vivo. In order to further evaluate the importance of immune response in the BLV model, we studied the fate of cells in which viral expression was transiently induced. Using a dual fluorochrome labeling approach, we show that ex vivo induction of viral expression induces higher death rates of B cells in vivo. Furthermore, cyclosporine treatment of these animals indicated that an efficient immune response is required to control virus expressing cells.
Disciplines :
Oncology
Author, co-author :
Florins, Arnaud-Francois ;  Université de Liège - ULiège > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc.
De Brogniez, Alix ;  Université de Liège - ULiège > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc.
Elemans, M.
Bouzar, A.-B.
François, C.
Reichert, M.
Asquith, B.
Willems, Luc  ;  Université de Liège - ULiège > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc.
Language :
English
Title :
Viral expression directs the fate of B cells in BLV-infected sheep.
Publication date :
January 2012
Journal title :
Journal of Virology
ISSN :
0022-538X
eISSN :
1098-5514
Publisher :
American Society for Microbiology (ASM), Washington, United States - District of Columbia
Volume :
86
Issue :
1
Pages :
621-624
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 30 November 2011

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