How HTLV-1 may subvert miRNAs for persistence and transformation.

[en] Distinct mechanisms are used by viruses to interact with cellular miRNAs. The role of microRNAs in viral replication and persistence ranges from viral-encoded microRNAs to suppressors of RNA interference. Viruses can also exploit cellular miRNAs for influencing cellular metabolism to ensure efficient replication or latency. In particular, two recent studies provide examples of how HTLV-1 may co-opt or subvert cellular miRNAs for persistent replication and oncogenic purposes. The pathways modulated by these described miRNAs are critically involved in apoptosis, proliferation and innate immune response.

Disciplines :

Oncology

Author, co-author :

Bouzar, Amel ; Université de Liège - ULiège > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc.

Willems, Luc ; Université de Liège - ULiège > GIGA-Research

Language :

English

Title :

How HTLV-1 may subvert miRNAs for persistence and transformation.

Publication date :

2008

Journal title :

Retrovirology

eISSN :

1742-4690

Publisher :

BioMed Central, London, United Kingdom

Volume :

Pages :

101

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 07 April 2009

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