Reference : Expression of interstitial collagenase (matrix metalloproteinase-1) is related to the...
Scientific journals : Article
Human health sciences : Reproductive medicine (gynecology, andrology, obstetrics)
http://hdl.handle.net/2268/103324
Expression of interstitial collagenase (matrix metalloproteinase-1) is related to the activity of human endometriotic lesions
English
Kokorine, Isabelle [ > > ]
NISOLLE, Michelle mailto [Centre Hospitalier Universitaire de Liège - CHU > > Gynécologie-Obstétrique CHR >]
Donnez, Jacques [ > > ]
Eeckhout, Yves [ > > ]
Courtoy, Pierre [ > > ]
Marbaix, Etienne [ > > ]
1997
Fertility and Sterility
Elsevier
68
2
246-251
Yes (verified by ORBi)
International
0015-0282
1556-5653
New York
NY
[en] Endometriosis ; collagenase ; MMP-1 ; extracellular matrix ; progesterone receptors
[en] Objective: To determine whether interstitial collagenase (matrix metalloproteinase-1), known to play a pivotal role in the initiation of menstruation, contributes to the pathogenesis of endometriosis.

Design: Serial sections of peritoneal red and black endometriotic lesions, ovarian endometriotic cysts, and rectovaginal adenomyotic nodules were analyzed by in situ hybridization for the expression of matrix metalloproteinase-1 by silver staining for the integrity of the fibrillar extracellular matrix and by immunolabeling for the abundance of sex steroid receptors.

Setting: Academic hospital and research laboratory.

Patient(s): Premenopausal women undergoing laparoscopy for endometriosis.

Intervention(s): Biopsy of endometriotic lesions, combined with endometrium whenever possible.

Main Outcome Measure(s): Expression of matrix metalloproteinase-1 messenger RNA (mRNA).

Result(s): Matrix metalloproteinase-1 mRNA was expressed focally in red peritoneal and ovarian endometriosis irrespective of the phase of the menstrual cycle but was not detectable in black peritoneal and rectovaginal lesions. Foci of matrix metalloproteinase-1 expression closely correlated with matrix breakdown and with the absence of P receptors in adjacent epithelial cells.

Conclusion(s): Correlation of matrix metalloproteinase-1 expression with activity of endometriotic tissue suggests its involvement in tissue remodeling and bleeding, and possibly in the secondary shedding and reimplantation of endometriotic lesions.
http://hdl.handle.net/2268/103324
10.1016/S0015-0282(97)81510-5

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