Reference : Taurine and ethanol preference : a microdialysis study using Sardinian alcohol-prefer...
Scientific journals : Article
Human health sciences : Psychiatry
Human health sciences : Pharmacy, pharmacology & toxicology
Social & behavioral sciences, psychology : Neurosciences & behavior
Taurine and ethanol preference : a microdialysis study using Sardinian alcohol-preferring and non-preferring rats
Quertemont, Etienne mailto [Université de Liège - ULg > Département des sciences cognitives > Psychologie quantitative >]
Lallemand, Frédéric [Université Catholique de Louvain - UCL > > Biologie du Comportement > >]
Colombo, Giancarlo [University of Cagliari > Department of Neurosciences > > >]
De Witte, Philippe [Université Catholique de Louvain - UCL > > Biologie du Comportement > >]
European Neuropsychopharmacology
Elsevier Science
Yes (verified by ORBi)
The Netherlands
[en] Ethanol ; Taurine ; Microdialysis ; Amino Acids ; Alcohol-preferring rats ; Alcohol-non-preferring rats
[en] Recent intracerebral microdialysis studies of different rat brain regions have shown that an acute ethanol injection induced a rapid dose-dependent increase in taurine microdialysate content during the first 60-min period. In taurine-supplemented rats, a reduced aversion for high ethanol doses was observed in a place conditioning paradigm, suggesting that taurine may be implicated in the regulation of some adverse effects of ethanol. The present study compares the effects of acute ethanol injections (1.0 and 2.0 g/ kg, i.p.) on taurine nucleus accumbens microdialysate content in Sardinian ethanol-preferring (sP) and Sardinian ethanol-non preferring (sNP) rats. While neither saline nor 1.0 g/kg ethanol injections had significant effect on taurine microdialysate concentration, 2.0 g/kg ethanol administration induced a rapid and significant increase in taurine microdialysate content in both sP and sNP rats. However, this ethanol-induced taurine release was significantly reduced in sP rats by comparison to sNP rats. As taurine is suggested to be released by brain cells to modulate different ethanol adverse effects, this lower taurine responsiveness to ethanol in sP rats by comparison to both sNP and Wistar rats may be a relevant indicator of reduced ethanol aversive effects in such animals and therefore be related to their higher alcohol consumption.
Centre de Neurosciences Cognitives et Comportementales
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Institut de Recherches Economiques sur les Boissons (IREB) ; LIPHA
Researchers ; Professionals

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