The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways.

[en] The lymphotoxin-beta receptor (LTbetaR) plays critical roles in inflammation and lymphoid organogenesis through activation of NF-kappaB. In addition to activation of the classical NF-kappaB, ligation of this receptor induces the processing of the cytosolic NF-kappaB2/p100 precursor to yield the mature p52 subunit, followed by translocation of p52 to the nucleus. This activation of NF-kappaB2 requires NIK and IKKalpha, while NEMO/IKKgamma is dispensable for p100 processing. IKKbeta-dependent activation of canonical NF-kappaB is required for the expression but not processing of p100 and for the expression of proinflammatory molecules including VCAM-1, MIP-1beta, and MIP-2 in response to LTbetaR ligation. In contrast, IKKalpha controls the induction by LTbetaR ligation of chemokines and cytokines involved in lymphoid organogenesis, including SLC, BLC, ELC, SDF1, and BAFF.

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Dejardin, Emmanuel ; Université de Liège - ULiège > GIGA-R : Virologie - Immunologie

Droin, Nathalie

Delhase, Mireille

Haas, Elvira

Cao, Yixue

Makris, Constantin

Li, Zhi-Wei

Karin, Michael

Ware, Carl

Green, Douglas

Language :

English

Title :

The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways.

Publication date :

October 2002

Journal title :

Immunity

ISSN :

1074-7613

eISSN :

1097-4180

Publisher :

Cell Press, Cambridge, United States - Massachusetts

Volume :

Pages :

525-535

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 14 November 2011

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793

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