Article (Scientific journals)
Retinoic acid induces TGFbeta-dependent autocrine fibroblast growth.
Fadloun, A.; Kobi, D.; Delacroix, Laurence et al.
2008In Oncogene, 27 (4), p. 477-89
Peer Reviewed verified by ORBi
 

Files


Full Text
Fadloun-Oncogene-2008.pdf
Publisher postprint (488.58 kB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Animals; Autocrine Communication/drug effects/genetics; Base Sequence; COS Cells; Cell Proliferation/drug effects; Cells, Cultured; Cercopithecus aethiops; Connective Tissue Growth Factor; Consensus Sequence; Fibroblasts/drug effects/physiology; Gene Expression Profiling; Gene Expression Regulation/drug effects; Immediate-Early Proteins/genetics; Intercellular Signaling Peptides and Proteins/genetics; Mice; Receptor Cross-Talk/drug effects; Receptors, Retinoic Acid/metabolism; Response Elements; Transcription Factor TFIID/genetics/metabolism/physiology; Transforming Growth Factor beta/genetics/physiology; Tretinoin/pharmacology
Abstract :
[en] To evaluate the role of murine TFIID subunit TAF4 in activation of cellular genes by all-trans retinoic acid (T-RA), we have characterized the T-RA response of taf4(lox/-) and taf4(-/-) embryonic fibroblasts. T-RA regulates almost 1000 genes in taf4(lox/-) cells, but less than 300 in taf4(-/-) cells showing that TAF4 is required for T-RA regulation of most, but not all cellular genes. We further show that T-RA-treated taf4(lox/-) cells exhibit transforming growth factor (TGF)beta-dependent autocrine growth and identify a set of genes regulated by loss of TAF4 and by T-RA corresponding to key mediators of the TGFbeta signalling pathway. T-RA rapidly and potently induces expression of connective tissue growth factor (CTGF) via a conserved DR2 type response element in its proximal promoter leading to serum-free autocrine growth. These results highlight the role of TAF4 as a cofactor in the cellular response to T-RA and identify the genetic programme of a novel cross talk between the T-RA and TGFbeta pathways that leads to deregulated cell growth.
Research center :
Giga-Neurosciences - ULiège
IGBMC
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Fadloun, A.
Kobi, D.
Delacroix, Laurence ;  Université de Liège - ULiège > Département des sciences cliniques > GIGA-R:Immunopath. - Maladies infect. et médec. inter. gén.
Dembele, D.
Michel, I.
Lardenois, A.
Tisserand, J.
Losson, R.
Mengus, G.
Davidson, I.
Language :
English
Title :
Retinoic acid induces TGFbeta-dependent autocrine fibroblast growth.
Publication date :
2008
Journal title :
Oncogene
ISSN :
0950-9232
eISSN :
1476-5594
Publisher :
Nature Publishing Group, Basingstoke, United Kingdom
Volume :
27
Issue :
4
Pages :
477-89
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
ANR - Agence Nationale de la Recherche [FR]
Available on ORBi :
since 14 November 2011

Statistics


Number of views
52 (5 by ULiège)
Number of downloads
0 (0 by ULiège)

Scopus citations®
 
17
Scopus citations®
without self-citations
11
OpenCitations
 
17

Bibliography


Similar publications



Contact ORBi