Taurine increases in the nucleus accumbens microdialysate after acute ethanol administration to naive and chronically alcoholised rats

Dahchour, Abdelkhader; Quertemont, Etienne; De Witte, Philippe

doi:10.1016/0006-8993(96)00537-9

Article (Scientific journals)

Taurine increases in the nucleus accumbens microdialysate after acute ethanol administration to naive and chronically alcoholised rats

Dahchour, Abdelkhader; Quertemont, Etienne; De Witte, Philippe

1996 • In Brain Research, 735, p. 9-19

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DOI
10.1016/0006-8993(96)00537-9

PubMed
8905164

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Keywords :

Ethanol; Taurine; Nucleus Accumbens; Glutamate; GABA; Microdialysis

Abstract :

[en] The extracellular changes of amino acids glutamate, taurine and GABA in the nucleus accumbens of freely moving rats were estimated using the microdialysis technique following acute and chronic ethanol injections (1, 2, and 3 g/kg body weight). Compared to baseline values, taurine increased by 154%, 142% and 162%, 20 min after the acute injection of, respectively, 1, 2 and 3 g/kg body weight ethanol, while 40 min after ethanol injection, taurine had increased by 124%, 146% and 168%. No changes in either glutamate or GABA were detected at any time points assayed. In the rats which had received chronic ethanol administration prior to a further acute ethanol injection (1, 2, and 3 g/kg body weight), taurine increased by 138%, 144% and 180%, 20 min after the ethanol injection, and at 40 min post ethanol injection taurine had increased by 134%, 160% and 158%, compared to the basal baseline value. No significant changes were observed in either glutamate or GABA microdialysate content in these chronic studies. The biological role played by taurine after acute ethanol injection in the nucleus accumbens remains unclear but may be associated with a yet, undefined mechanism, in reducing the cytotoxicity of ethanol.

Research Center/Unit :

Centre de Neurosciences Cognitives et Comportementales - ULiège

Disciplines :

Pharmacy, pharmacology & toxicology
Psychiatry
Neurosciences & behavior

Author, co-author :

Dahchour, Abdelkhader; Université Catholique de Louvain - UCL > Biologie du comportement

Quertemont, Etienne ; Université de Liège - ULiège > Département des sciences cognitives > Psychologie quantitative

De Witte, Philippe; Université Catholique de Louvain - UCL > Biologie du comportement

Language :

English

Title :

Taurine increases in the nucleus accumbens microdialysate after acute ethanol administration to naive and chronically alcoholised rats

Publication date :

1996

Journal title :

Brain Research

ISSN :

0006-8993

eISSN :

1872-6240

Publisher :

Elsevier, Amsterdam, Netherlands

Volume :

735

Pages :

9-19

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique
IREB - Institut de Recherches Scientifiques sur les Boissons
LIPHA

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Bibliography

[1] Allan, A.M. and Harris, R.A., Acute and chronic ethanol treatment alter GABA receptor operated-chloride channel, Pharmacol. Biochem. Behav., 27 (1987) 665-670.
[2] Allan, A.M. and Harris, R.A., Ethanol and barbiturates enhance GABA-stimulated influx of 35Cl- in isolated brain membranes, Pharmacology , 27 (1987) 125.
[3] Allan, A.M. and Harris, R.A., γ-Aminobutyric acid and alcohol action: neurochmical studies, Life Sci., 39 (1986) 2005-2015.
[4] Aragon, C.M.G. and Amit, Z., Taurine and ethanol-induced conditioned taste aversion, Pharmacol. Biochem. Behav., 44 (1993) 263-266.
[5] Aragon, C.M.G., Trudeau, L.E. and Amit, Z., Effect of taurine on ethanol-induced changes in open-field locomotor activity, Psychopharmacology, 107 (1992) 337-340.
[6] Boggan, W.O., Medberry, C., Hopkins, D.H., Effect of taurine on some pharmacological properties of ethanol, Pharmacol. Biochem. Behav., 9 (1978) 469-472.
[7] Buck, K.J. and Harris, R.A., Benzodiazepine agonist and inverse agonist actions on GABAA receptor-operated chloride channels. II. Chronic effects of ethanol, J. Pharmacol. Exp. Ther., 253 (1990) 713-719.
[8] Dahchour, A., Quertemont, E. and De Witte, Ph., Acute ethanol increases taurine but neither glutamate nor GABA in the nucleus accumbens of male rats: a microdialysis study, Alcohol Alcoholism, 29 (1994) 485-487.
[9] Danysz, W., Dyr, W., Jankowska, E., Glazewski, S. and Kostowski, W., The involvement of NMDA receptors in acute and chronic effects of ethanol, Alcohol Clin. Exp. Res., 16 (1992)499-504.
[10] Davison, N.A. and Kaczmarek, L.N., Taurine: a possible neurotransmitter? Nature, 234 (1971) 107-108.
[11] Deitrich, R.A., Dunwiddie, T.V., Harris, R.A. and Erwin, V.G., Mechanism of action of ethanol: initial central nervous system actions, Pharmacol. Rev., 41 (1989) 489-537.
[12] Dildy-Mayfield, J.E. and Leslie, S.W., Mechanism of inhibition of N-methyl-D-aspartate-stimulated increases in free intracellular Ca2+ concentration by ethanol, J. Neurochem., 5619911536-1543.
[13] Donzanti, B.A. and, Yamamoto, B.K., An improved and rappid HPLC-EC method for the isocratic separation of amino acids neurotransmitters from brain tissue and microdialysate perfusate, Life Sci., 43 (1988) 913-922.
[14] Fadda, F., Mosca, E., Colombo, G. and Gessa, G.L., Alcohol-preferring rats genetic sensitivity to alcohol-induced stimulation of dopamine metabolism, Physiol. Behav., 47 1990727-729.
[15] Glue, P. and Nutt, D., Overexcitement and disinhibition. Dynamic neurotransmitter interactions in alcohol withdrawal, Br. J. Psychiatry, 157 (1990) 491-499.
[16] Grant, K.A., Kinsely, J.S., Tabakoff, B., Barrette, J.E. and Balster, R.L., Ethanol-like discriminative stimulus effect of non-competitive N-methyl-D-aspartate agonists, Behav. Pharmacol., 2 (1991) 87-95.
[17] Graybiel, A.M., Neurotransmitters and neuromodulators in the basal ganglia, Trends Neurosci., 13 (1990) 244-250.
[18] Gullans, S.R. and Verbalis, J.G., Control of brain volume during hyperosmolar and hypoosmolar conditions, Annu. Rev. Med., 44 (1993) 289-301.
[19] Heidbreder, C. and De Witte, Ph., Ethanol differentially affects extracellular monoamines and GABA in the nucleus accumbens, Pharmacol. Biochem. Behav., 46 (1993) 477-481.
[20] Hernandez, L. and Hoebel, B.G., Food reward and cocaine increase extracellular dopamine in the nucleus accumbens as measured by microdialysis, Life Sci., 42 (1988) 705-712.
[21] Hoebel, B.G. and Novin, D., The Neural Basis of Feeding and Reward, Haer Institute, Brunswick, ME, 1982.
[22] Hoffman, P.L., Rab, C.S., Moses, F. and Tabakoff, B., NMDA receptors and ethanol inhibition of calcium flux and cyclic GMP production, J. Neurochem., 52 (1989) 1937-1940.
[23] Hoffman, P.L., Grant, K.A., Snell, L.D., Reinlib, L., Iorio, K. and Tabakoff, B., NMDA receptors: role in ethanol withdrawal seizures. In P.W. Kalivas, and H.H. Samson, The Neurobiology of Drug and Alcohol Addiction, The New York Academy of Sciences, New York, 1992, pp. 52-60.
[24] Huxtable, R.J., Taurine in the central nervous system and the mammalian action of taurine, Prog. Neurobiol., 32 (1989) 471-533.
[25] Imperato, A. and DiChiara, G., Preferential stimulation of dopamine release in the nucleus accumbens of freely moving rats by ethanol, J. Pharmacol. Exp. Ther., 239 (1986) 219-228.
[26] Iwata, H., Matsuda, T., Lee, E., Yamagami, S. and Baba, A., Effect of ethanol on taurine concentration in the brain, Experientia, 36 (1980) 332-333.
[27] Khatib, S.A., Murphy, J.M. and McBride, W.G., Biochemical evidence for activation of specific monoamine pathways by alcohol. Alcohol, 5 (1988) 295-299.
[28] Kimelberg, H.K., Cheema, M., O'Connor, E.R., Tong, H., Goderie, S.K. and Rossman, P.A., Ethanol-induced aspartate and taurine release from primary astrocyte cultures, J. Neurochem., 60 (1993) 1682-1689.
[29] Kontro, P., Interactions of taurine and dopamine in the striatum. In R.J. Huxtable, F. Franconi and A. Giotti, The Biology of Taurine: Methods and Mechanisms, Plenum Press, New York, 1987, pp. 347-355.
[30] Koob, G.F. and Bloom, F.E., Cellular and molecular mechanisms of drug dependence, Science, 242 (1988) 715-721.
[31] Korpi, E.R., Role of GABAA receptors in the actions of alcohol and in alcoholism: recent advances, Alcohol Alcoholism, 29 (1994) 115-129.
[32] Kuriyama, K. and Ueha, T., Functional alterations in cerebral GABAA receptor complex associated with formation of alcohol dependence analysis using GABA-dependent 36Cl- influx into neuronal membrane vesicles, Alcohol Alcoholism, 27 (1992) 335-343.
[33] Li, Y.P. and Lombardini, J.B., Inhibition by taurine of the phosphorylation of specific synaptosomal proteins in rat cortex: effects of taurine on the stimulation of calcium uptake in mitochondria and inhibition of phosphoinositide turnover, Brain Res., 553 (1991) 89-96.
[34] Liljequist, R., Interaction of taurine and related compounds with GABAergic neurones in the nucleus raphe dorsalis, Pharmacol. Biochem. Behav., 44 (1993) 107-112.
[35] Lombardini, J.B., Regional and subcellular studies on taurine in the rat cerebral nervous systems. In R.J. Huxtable and A. Barbeau (Eds.), Taurine, Raven Press, New York, 1976, p. 311.
[36] Lovinger, D.M., White, G. and Weight, F.F., Ethanol inhibits NMDA-activated ion current in hippocampal neurons, Science, 243 (1989) 1721-1724.
[37] Magnusson, K.R., Madl, J.E., Clements, J.R., Wu, J.Y., Larson, A.A. and Beitz, A.J., Co-localization of taurine and cysteine sulfinic acid decarboxylase-like immunoreactivity in the hippocampus of the rat, J. Neurosci., 8 (1988) 4451.
[38] Mark, G., Rada, P., Pothos, E. and Hoebel, B.G., Effect of feeding and drinking on acetylcholine release in the nucleus accumbens, striatum and hippocampus of freely behaving rats, J. Neurochem., 58 (1992) 2269-2274.
[39] McBroom, M.J., Elkhawad, A.O. and Dlouha, H., Taurine and ethanol-induced sleeping time in mice: route and time course effects, Gen. Pharmacol., 17 (1986) 97-100.
[40] Mereu, G. and Gessa, G. L., Loww doses of ethanol inhibit the firing of neurons in the substantia nigra pars reticulata: a GABAergic effect? Brain Res., 360 (1985) 325-330.
[41] Mogenson, G.J., Jones, D.L., Yim, C.Y., From motivation to action: functional interface between limbic and motor systems, Prog. Neurobiol., 14 (1980) 69-97.
[42] Mogenson, G.J., Limbic-motor integration. In A. Epstein and A.R. Morrison (Eds.), Progress in Psychobiology and Physiological Psychology, Academic Press, New York, 12, 1987, pp. 117-170.
[43] Morrow, A.L., Suzdak, P.D., Karanian, J.R., Paul, S.M., Chronic ehanol administration alters g-aminobutyric acid, pentobarbital and ethanol mediated 36Cl- uptake in cerebral cortical synaptosomes, J. Pharmacol. Exp. Ther., 246 (1988) 158-164.
[44] Murphy, J.M., McBride, W.G., Gatto, G.J., Lumeng, L. and Li, T.K., Effects of acute ethanol administration on monoamine and metabolite content in forebrain regions of ethanol-tolerant and non-tolerant alcohol-preferring (P) rat, Pharmacol. Biochem. Behav., 29 (1988) 169-174.
[45] Nagelhus, E.A., Amiry-Moghaddam, M., Lehmann, A. and Ottersen, O.P., Taurine as an organic osmolyte in the intact brain immunocytochemical and biochemical studies. In R.J. Huxtable and D. Michalk, Taurine in Health and Disease, Plenum Press, New York, 1994, pp. 325-334.
[46] Nauta, W.J.H., Smith, G.P., Domesick, V.B. and Faull, R.L.M., Efferent connections and nigral afferents of the nucleus accumbens septi in the rat, Neuroscience, 3 (1978) 385-401.
[47] Nie, Z., Yuan, X., Madamba, S.G. and Siggins, G.R., Ethanol decreases glutamatergic synaptic transmission in rat nucleus accumbens in vitro: naloxone reversal, J. Pharmacol. Exp. Ther., 266 (1993) 1705-1712.
[48] North, R.A., Cellular actions of opiates and cocaine. In P.W. Kalivas, and H.H. Samson, The Neurobiology of Drug and Alcohol Addiction, The New York Academy of Sciences, New York, 1992, pp. 1-6.
[49] Oja, S.S. and Kontro, P., Taurine. In Lajtha (Ed.), Handbook of Neurochemistry, Vol. 3, Plenum Press, New York, 1983, pp. 501-533.
[50] Oja, S.S. and Saransaari, P., Relations of taurine release and influx to cell volumes in cerebral cortical slices. In R.J. Huxtable and D. Michalk, Taurine in Health and Disease, Plenum Press, New York, 1994, pp. 269-277.
[51] Ollat, H., Parvez, H. and Parvez, S., Alcohol and central neurotransmission, Neurochem. Int., 13 (1988) 275-300.
[52] Pasantes-Morales, H., Chacón, E., Sánchez-Olea, R. and Morán, J., Volume regulation in cultured neurons: pivotal role of taurine. In R.J. Huxtable and D. Michalk, Taurine in Health and Disease, Plenum Press, New York, 1994, pp. 317-323.
[53] Paxinos, G. and Watson, C., The Rat Brain in Stereotaxic Coordinates, Academic Press, New York, 1982.
[54] Proctor, W.R., Allan, A.M. and Dunwiddie, T.V., Brain region-dependent sensitivity of GABAA receptor-mediated responses to modulation by ethanol, Alcohol. Clin. Exp. Res., 16 124-130.
[55] Reggiani, A., Brabaccia, M. L., Spano, P. F. and Trabucchi, M., Dopamine metabolism and receptor function after acute and chronic ethanol, J. Neurochem., 35 (1980) 34-37.
[56] Robinson, T.E. and Whishaw, I.Q., Normalization of extracellular dopamine in striatum following recovery from a partial unilateral 6-OHDA lesion of the substantia nigra: a microdialysis study in freely moving rats, Brain Res., 450 (1988) 209-224.
[57] Samson, H.H. and Harris, R.A., Neurobiology of alcohol abuse, Trends Pharmacol. Sci., 13 1992206-211.
[58] Sanna, E., Serra, M., Cossu, A., Colombo, G., Follesa, P., Cuccheddu, T., Concas, A. and Biggio, G., Chronic ethanol intoxication induces differential effects on GABAA and NMDA receptor function in the rat brain, Alcohol. Clin. Exp. Res., 17 (1993) 115-123.
[59] Sanna, E., Concas, A., Serra, M., Santoro, G., Biggio, G., Ex vivo binding of t-[-35S]butylbicyclophosphorothionate: a biochemical tool to study the pharmacology of ethanol at the gamma-aminobutyric acid-coupled chloride channel, J. Pharmacol. Exp. Ther., 256 (1991) 922-928.
[60] Schuller-Levis, G., Quinn, M.R., Wright, C. and Park, E., Taurine protects against oxidant-induced lung injury possible mechanism(s) of action. In R.J. Huxtable and D. Michalk, Taurine in Health and Disease, Plenum Press, New York, 1994, pp. 31-39.
[61] Schwartz, R.D., Suzdak, P.D., Paul, S.M., Gamma-aminobutyric acid (GABA) and barbiturate-mediated 36Cl- uptake in rat brain synaptosomes: evidence for rapid desensitization of the GABA receptor-coupled chloride channel, Mol. Pharmacol., 30 (1986) 419-426.
[62] Simson, P.E., Criswell, H.E., Johnson, K.B., Hicks, R.E. and Breese, G.R. Ethanol inhibits NMDA-evoked electrophysiological activity in vivo, J. Pharmacol. Exp. Ther., 257 (1991) 225-231.
[63] Stinus, L., Le Moal, M. and Koob, G.F., Nucleus accumbens and amygdala are possible substrates for the aversive stimulus effect of opiate withdrawal, Neuroscience, 37 (1990) 767-773.
[64] Sutton, J. and Simmonds, M. A., Effect of acute and chronic ethanol on the γ-aminobutyric acid system in rat brain, Biochem. Pharmacol., 22 (1973) 1685-1692.
[65] Tabakoff, B. and Hoffman, P.L., Alcohol: neurobiology. In J.H. Lowinson, P. Ruiz and R.B. Millwan (Eds.), Substance Abuse: A Comprehension Textbook, Williams and Wilkins, Baltimore, 1992, pp. 152-185.
[66] Tappaz, M., Almarghini, K. and Do, K., Cysteine sulfinate decarboxylase in brain identification, characterization and immunocytochemical localization in astrocytes. In R.J. Huxtable and D. Michalk, Taurine in Health and Disease, Plenum Press, New York, 1994, pp. 257-268.
[67] Ticku, M.K., Lowrimore, P. Lehoulier, P., Ethanol enhances GABA-induced 36Cl- influx in primary spinal cord cultured neurons, Brain Res. Bull., 17 (1986) 123-126.
[68] Wade, J.V., Olson, J.P., Samson, F.E., Nelson, S.R. and Pazdernik, T.L., A possible role for taurine in osmoregulation within the brain, J. Neurochem., 51 (1988) 740-745.
[69] Weight, F.F., Lovinger, D.M. and White, G., Alcohol inhibition of NMDA channel function. Alcohol Alcohol., Suppl., 1 (1991) 163-169.
[70] Wise, R.A., Opiate reward sites and substrates, Neurosci. Biobehav. Rev., 13 (1989) 129-71.
[71] Wright, C.E., Tallan, H.H., Lin, Y.Y. and Gaull, G.E., Taurine: biological update, Annu. Rev. Biochem., 55 (1986) 427-453.
[72] Wu, J.-Y., Lin, C.-T., Johansen, F.F. and Liu, J.-W., Taurine neurons in rat hippocampal formation are relatively inert to cerebral ischemia. In R.J. Huxtable and D. Michalk, Taurine in Health and Disease, Plenum Press, New York, 1994, pp. 289-298.
[73] Yoshimoto, K., Murphy, J. M., McBride, W.G., Lumeng, L. and Li, T.K., Alcohol stimulates the release of dopamine and serotonin in the nucleus accumbens, Alcohol, 9 199217-22.