Structure and development of cochlear afferent innervation in mammals.

[en] In mammals, sensorineural deafness results from damage to the auditory receptors of the inner ear, the nerve pathways to the brain or the cortical area that receives sound information. In this review, we first focused on the cellular and molecular events taking part to spiral ganglion axon growth, extension to the organ of Corti, and refinement. In the second half, we considered the functional maturation of synaptic contacts between sensory hair cells and their afferent projections. A better understanding of all these processes could open insights into novel therapeutic strategies aimed to re-establish primary connections from sound transducers to the ascending auditory nerve pathways.

Research Center/Unit :

Giga-Neurosciences - ULiège

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Defourny, Jean ; Université de Liège - ULiège > Doct. sc. bioméd. & pharma. (Bologne)

Lallemend, Francois

Malgrange, Brigitte ; Université de Liège - ULiège > GIGA - Neurosciences

Language :

English

Title :

Structure and development of cochlear afferent innervation in mammals.

Publication date :

2011

Journal title :

American Journal of Physiology - Cell Physiology

ISSN :

0363-6143

eISSN :

1522-1563

Publisher :

American Physiological Society, Bethesda, United States - Maryland

Volume :

301

Issue :

Pages :

C750-61

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique
Fonds Léon Fredericq
FRSM - Fonds de la Recherche Scientifique Médicale

Available on ORBi :

since 13 November 2011

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