Other (Scientific journals)
Chimerism and outcomes after allogeneic hematopoietic cell transplantation following nonmyeloablative conditioning
Baron, Frédéric; Sandmaier, B. M.
2006In Leukemia, 20 (10), p. 1690-1700
Peer Reviewed verified by ORBi
 

Files


Full Text
BaronChimLeuk06.pdf
Publisher postprint (216.62 kB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
hematopoietic cell transplantation; nonmyeloablative conditioning; donor chimerism; T-cells; NK cells
Abstract :
[en] Allogeneic hematopoietic cell transplantation ( HCT) following nonmyeloablative conditioning has been extensively evaluated in patients with hematologic malignancies who are ineligible for conventional HCT because of age or medical comorbidities. Nonmyeloablative regimens have led to an initial state of mixed hematopoietic chimerism defined as coexistence of donor- and host-derived hematopoiesis. While nonmyeloablative regimens have been associated with reduced regimen-related toxicities in comparison with conventional myeloablative conditioning, graft rejection, graft-versus-host disease ( GVHD), and disease progression have remained significant challenges. In this article, after briefly introducing current techniques for chimerism assessment, we describe factors affecting donor chimerism levels after nonmyeloablative conditioning, and then review data suggesting that chimerism assessment early after HCT might help identify patients at risk for graft rejection, GVHD and relapse/progression. Finally, we discuss how these observations have opened the way to further research protocols evaluating manipulation of postgrafting immunosuppression, and/or infusion of donor immune cells.
Disciplines :
Oncology
Hematology
Author, co-author :
Baron, Frédéric  ;  Université de Liège - ULiège > Département des sciences cliniques > Hématologie
Sandmaier, B. M.
Language :
English
Title :
Chimerism and outcomes after allogeneic hematopoietic cell transplantation following nonmyeloablative conditioning
Publication date :
October 2006
Journal title :
Leukemia
ISSN :
0887-6924
eISSN :
1476-5551
Publisher :
Nature Publishing Group, London, United Kingdom
Volume :
20
Issue :
10
Pages :
1690-1700
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 08 November 2011

Statistics


Number of views
149 (0 by ULiège)
Number of downloads
255 (0 by ULiège)

Scopus citations®
 
146
Scopus citations®
without self-citations
127
OpenCitations
 
129

Bibliography


Similar publications



Contact ORBi