Chimerism and outcomes after allogeneic hematopoietic cell transplantation following nonmyeloablative conditioning

[en] Allogeneic hematopoietic cell transplantation ( HCT) following nonmyeloablative conditioning has been extensively evaluated in patients with hematologic malignancies who are ineligible for conventional HCT because of age or medical comorbidities. Nonmyeloablative regimens have led to an initial state of mixed hematopoietic chimerism defined as coexistence of donor- and host-derived hematopoiesis. While nonmyeloablative regimens have been associated with reduced regimen-related toxicities in comparison with conventional myeloablative conditioning, graft rejection, graft-versus-host disease ( GVHD), and disease progression have remained significant challenges. In this article, after briefly introducing current techniques for chimerism assessment, we describe factors affecting donor chimerism levels after nonmyeloablative conditioning, and then review data suggesting that chimerism assessment early after HCT might help identify patients at risk for graft rejection, GVHD and relapse/progression. Finally, we discuss how these observations have opened the way to further research protocols evaluating manipulation of postgrafting immunosuppression, and/or infusion of donor immune cells.

Disciplines :

Oncology
Hematology

Author, co-author :

Baron, Frédéric ; Université de Liège - ULiège > Département des sciences cliniques > Hématologie

Sandmaier, B. M.

Language :

English

Title :

Chimerism and outcomes after allogeneic hematopoietic cell transplantation following nonmyeloablative conditioning

Publication date :

October 2006

Journal title :

Leukemia

ISSN :

0887-6924

eISSN :

1476-5551

Publisher :

Nature Publishing Group, London, United Kingdom

Volume :

Issue :

Pages :

1690-1700

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 08 November 2011

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284 (0 by ULiège)

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Scopus citations^®

148

Scopus citations^®
without self-citations

129

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129

OpenAlex citations

165

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