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Consequences of total and subtotal myeloperoxidase deficiency: risk or benefit ?

Kutter, D.; Devaquet, P.; Vanderstocken, G. et al.

2000 • In Acta Haematologica, 104 (1), p. 10-5

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/101975

DOI
10.1159/000041062

PubMed
11111115

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Keywords :

Adolescent; Adult; Aged; Aged, 80 and over; Arthritis/enzymology/etiology; Cardiovascular Diseases/enzymology/prevention & control; Case-Control Studies; Chi-Square Distribution; Child; Child, Preschool; Chronic Disease; Female; Humans; Infection/enzymology/etiology; Male; Middle Aged; Myocardial Infarction/enzymology/prevention & control; Neoplasms/enzymology/etiology; Peroxidase/blood/deficiency/pharmacology; Risk Factors

Abstract :

[en] A group of 100 totally or subtotally myeloperoxidase (MPO)-deficient individuals was compared to a reference population of 118 probands selected at random. Data for a protective effect of the deficiency against cardiovascular damage are presented. On the other hand, a significantly higher occurrence of severe infections and chronic inflammatory processes was noted among the deficient patients. An increased incidence of cancer among the MPO-deficient individuals was not demonstrated.

Disciplines :

Hematology

Author, co-author :

Kutter, D.

Devaquet, P.

Vanderstocken, G.

Paulus, Jean-Michel ; Université de Liège - ULiège > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine)

Marchal, V.

GOTHOT, André ; Centre Hospitalier Universitaire de Liège - CHU > Hématologie biologique et immuno hématologie

Language :

English

Title :

Consequences of total and subtotal myeloperoxidase deficiency: risk or benefit ?

Publication date :

2000

Journal title :

Acta Haematologica

ISSN :

0001-5792

eISSN :

1421-9662

Publisher :

S. Karger

Volume :

104

Issue :

1

Pages :

10-5

Peer reviewed :

Peer Reviewed verified by ORBi

Commentary :

Copyright 2000 S. Karger AG, Basel

Available on ORBi :

since 08 November 2011

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185

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258

Bibliography

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