Reference : Allogeneic hematopoietic stem cell transplantation (HSCT) after reduced intensity con...
Scientific journals : Article
Human health sciences : Hematology
Allogeneic hematopoietic stem cell transplantation (HSCT) after reduced intensity conditioning
SERVAIS, Sophie [Centre Hospitalier Universitaire de Liège - CHU > > Frais communs médecine >]
Baron, Frédéric [Université de Liège - ULiège > > GIGA-R : Hématologie >]
Beguin, Yves mailto [Université de Liège - ULiège > > GIGA-R : Hématologie >]
Transfusion & Apheresis Science
Elsevier Science
Yes (verified by ORBi)
[en] reduced-intensity conditioning ; hematopoietic stem cell transplantation ; graft-versus-tumor effects ; graft-versus-host disease
[en] Allogeneic hematopoietic stem cell transplantation (HSCT) following myeloablative (conventional) conditioning regimen is associated with a high incidence of transplant-related morbidity and mortality, limiting its use to younger patients without medical co-morbidities. Over the past few years, it has become more evident that the alloreactivty of transplanted donor immunocompetent cells against host tumor cells (graft-versus-tumor effects, GVT effects) plays a major role in eradicating malignancies after allogeneic HSCT. Based on these observations, several groups of investigators have developed reduced intensity conditioning (RIC) regimens allowing patients who are ineligible for conventional HSCT to benefit from the potentially curative GVT effects of allogeneic transplantation. Retrospective studies have suggested that, in comparison with myeloablative allogeneic HSCT, in patient aged 40-60 years, RIC HSCT was associated with a higher risk of relapse but a lower incidence of transplant-related mortality leading to similar progression-gree and overall survivals. Prospective studies are ongoing to define which patients might most benefit from RIC HSCT, and to increase the anti-tumoral activity of the procedure while reducing the incidence and the severity of acute graft-versus-host disease (GVHD). In this article, we review the current status and perspectives of RIC HSCT.

File(s) associated to this reference

Fulltext file(s):

Open access
275.pdfPublisher postprint326.78 kBView/Open

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.