Environmental factors affecting thyroid function of wild sea bass (Dicentrarchus labrax) from European coasts

[en] Thyroid functional status of wild fish in relation with the contamination of their environment deserves further investigation. We here applied a multi-level approach of thyroid function assessment in 87 wild sea bass collected near several estuaries: namely the Scheldt, the Seine, the Loire, the Charente and the Gironde. Thyroxine (T4) and triiodothyronine (T3) concentrations in muscle were analyzed by radioimmunoassay. The activity of hepatic enzymes involved in extrathyroidal pathways of thyroid hormone metabolism, viz. deiodination, glucuronidation and sulfatation were analyzed. Last, follicle diameter and epithelial cell heights were measured. We observed changes that are predicted to lead to an increased conversion of T4–T3 and lowered thyroid hormone excretion. The changes in the metabolic pathways of thyroid hormones can be interpreted as a pathway to maintain thyroid hormone homeostasis. From all compounds tested, the higher chlorinated PCBs seemed to be the most implicated in this perturbation.

Research Center/Unit :

MARE - Centre Interfacultaire de Recherches en Océanologie - ULiège
AFFISH-RC - Applied and Fundamental FISH Research Center - ULiège

Disciplines :

Aquatic sciences & oceanology

Author, co-author :

Schnitzler, Joseph ; Université de Liège - ULiège > Département des sciences et gestion de l'environnement > Océanologie

Klaren, Peter

Bouquegneau, Jean-Marie ; Université de Liège - ULiège > Département des sciences et gestion de l'environnement > Océanologie

Das, Krishna ; Université de Liège - ULiège > Département des sciences et gestion de l'environnement > Océanologie

Language :

English

Title :

Environmental factors affecting thyroid function of wild sea bass (Dicentrarchus labrax) from European coasts

Publication date :

2012

Journal title :

Chemosphere

ISSN :

0045-6535

eISSN :

1879-1298

Publisher :

Elsevier Science, Oxford, United Kingdom

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

FRIA - Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture

Available on ORBi :

since 26 October 2011

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