Reference : Intensive conventional chemotherapy (ACVBP regimen) compared with standard CHOP for p...
Scientific journals : Article
Human health sciences : Hematology
Intensive conventional chemotherapy (ACVBP regimen) compared with standard CHOP for poor-prognosis aggressive non-Hodgkin lymphoma
Tilly, Hervé [> >]
Lepage, Eric [> >]
Coiffier, Bertrand [> >]
Blanc, Michel [> >]
Herbrecht, Raoul [> >]
Bosly, André [> >]
Attal, Michel [> >]
Fillet, Georges mailto [Université de Liège - ULiège > Département des sciences cliniques > Hématologie - Oncologie médicale >]
Guettier, Catherine [> >]
Jo Molina, Thierry [> >]
Gisselbrecht, Christian [> >]
Reyes, Félix [> >]
American Society of Hematology
Yes (verified by ORBi)
[en] We conducted a randomized trial to compare the intensive conventional chemotherapy regimen ACVBP (doxorubicin, cyclophosphamide, vindesine, bleomycin, prednisone) with standard CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) in previously untreated patients with poor-risk aggressive lymphoma. Patients aged 61 to 69 years who had aggressive non-Hodgkin lymphoma with at least one prognostic factor of the age-adjusted international prognostic index (IPI) were included. ACVBP consisted of an induction phase of intensified chemotherapy and central nervous system (CNS) prophylaxis followed by a sequential consolidation phase. Of the 708 patients registered for the study, 635 were eligible. The rate of complete response was 58% in the ACVBP group and 56% in the CHOP group (P =.5). Treatment-related death occurred in 13% of the ACVBP group and 7% of the CHOP group (P =.014). At 5 years, the event-free survival was 39% in the ACVBP group and 29% in the CHOP group (P =.005). The overall survival was significantly longer for patients treated with ACVBP, at 5 years it was 46% compared with 38% for patients treated with CHOP (P =.036). CNS progressions or relapses were more frequent in the CHOP group (P =.004). Despite higher toxicity, the ACVBP regimen, used as first-line treatment for patients with poor-risk aggressive lymphoma, is superior to standard CHOP with regard to both event-free survival and overall survival. (C) 2003 by The American Society of Hematology.

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