Increment in molecular weight of poly (dimethylamino-ethylmethacrylate) based polymers cause strong red blood cell aggregation but not hemolytic response.

Polycations are frequently reported to tailor drug delivery systems,
there is still a need to better correlate theirmacromolecular features with
their biocompatibility, in particular with blood. In this view, we have
analysed the RBC aggregation and hemolysis response caused by poly
(dimethylamino-ethylmethacrylate) or poly(ethyleneimine) under a
free form, i.e. without their preliminary association with polyanionic
drug. Our results highlight that the molecular weight of PDMAEMA
significantly affects theRBC aggregationwithout inducing any hemolysis.