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Increment in molecular weight of poly (dimethylamino-ethylmethacrylate) based polymers cause strong red blood cell aggregation but not hemolytic response.
Cerda Cristerna, Bernardino Isaac; Flores, Héctor; Pozos, Amaury et al.
2010 • In Journal of Controlled Release, 148 (1), p. 30-e31
Peer Reviewed verified by ORBi
Permalink
https://hdl.handle.net/2268/100167
DOI
10.1016/j.jconrel.2010.07.040
PubMed
21529606
 

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Keywords :
Poly(2-dimethylamino-ethylmethacrylate); Hemocompatibility; red blood cells; hemagglutination; hemolysis; red blood cell aggregation
Abstract :
[en] Polycations are frequently reported to tailor drug delivery systems, there is still a need to better correlate theirmacromolecular features with their biocompatibility, in particular with blood. In this view, we have analysed the RBC aggregation and hemolysis response caused by poly (dimethylamino-ethylmethacrylate) or poly(ethyleneimine) under a free form, i.e. without their preliminary association with polyanionic drug. Our results highlight that the molecular weight of PDMAEMA significantly affects theRBC aggregationwithout inducing any hemolysis.
Research Center/Unit :
CEIB - Centre Interfacultaire des Biomatériaux - ULiège
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Cerda Cristerna, Bernardino Isaac ;  Université de Liège - ULiège > GIGA - Utilisateurs machines
Flores, Héctor
Pozos, Amaury
Sevrin, Chantal ;  Université de Liège - ULiège > Centre interfacultaire des biomatériaux (CEIB)
Grandfils, Christian ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine
Language :
English
Title :
Increment in molecular weight of poly (dimethylamino-ethylmethacrylate) based polymers cause strong red blood cell aggregation but not hemolytic response.
Publication date :
20 November 2010
Journal title :
Journal of Controlled Release
ISSN :
0168-3659
eISSN :
1873-4995
Publisher :
Elsevier Science, Amsterdam, Netherlands
Volume :
148
Issue :
1
Pages :
e30-e31
Peer reviewed :
Peer Reviewed verified by ORBi
Additional URL :
http://www.sciencedirect.com/science/article/pii/S0168365910005213
Available on ORBi :
since 14 October 2011

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