Increment in molecular weight of poly (dimethylamino-ethylmethacrylate) based polymers cause strong red blood cell aggregation but not hemolytic response.
Poly(2-dimethylamino-ethylmethacrylate); Hemocompatibility; red blood cells; hemagglutination; hemolysis; red blood cell aggregation
Abstract :
[en] Polycations are frequently reported to tailor drug delivery systems,
there is still a need to better correlate theirmacromolecular features with
their biocompatibility, in particular with blood. In this view, we have
analysed the RBC aggregation and hemolysis response caused by poly
(dimethylamino-ethylmethacrylate) or poly(ethyleneimine) under a
free form, i.e. without their preliminary association with polyanionic
drug. Our results highlight that the molecular weight of PDMAEMA
significantly affects theRBC aggregationwithout inducing any hemolysis.
Research center :
CEIB - Centre Interfacultaire des Biomatériaux - ULiège
Sevrin, Chantal ; Université de Liège - ULiège > Centre interfacultaire des biomatériaux (CEIB)
Grandfils, Christian ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine
Language :
English
Title :
Increment in molecular weight of poly (dimethylamino-ethylmethacrylate) based polymers cause strong red blood cell aggregation but not hemolytic response.
