Cholestase associée à l'administration de ticlopidine

Ticlopidine is a antitrombotic agent. Cholestasis is an unfrequent adverse effect of ticlopidine. Althought transient liver transaminases elevations have been decribed in nearly 5% of cases, only 18 cases of ticlopidine associated cholestasis have been published. No such a case has been described untill now in Latinoamerica. We describe the case of a 56 years old male with ticlopidine associated cholestasis. Liver biopsy showed acinar cholestasis and portal inflammatory infiltrate suggesting cholestasis due to hypersensitivity. The drug was discontinuated and not readministered. There was subsequently a progressive normalization of liver parameters. Althought rare, clinicians should be aware of this unfrequent adverse effect of ticlopidine.