Scheen, André ; Université de Liège - ULiège > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale
Paquot, Nicolas ; Université de Liège - ULiège > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine)
Castillo, M. J.
Lefebvre, P. J.
Language :
English
Title :
How to Measure Insulin Action in Vivo
Publication date :
July 1994
Journal title :
Diabetes/Metabolism Reviews
ISSN :
0742-4221
eISSN :
1099-0895
Publisher :
John Wiley & Sons, Hoboken, United States - New York
Bergman RN, Finegood DT, Ader M (1985) Assessment of insulin sensitivity in vivo. Endocrine Rev 6:45-86.
Turner RC, Rudenski AS, Holman RR, Matthews DR, O'Rahilly SP (1987) Quantitative modelling of endocrine diseases as exemplified by diabetes. Clin Endocrinol (Oxford) 26:107-116.
Gerich JE (1993) Control of glycaemia. Baillière's Clin Endocrinol Metab 7:551-586.
Ader M, Bergman RN (1987) Insulin sensitivity in the intact organism. Baillière's Clin Endocrinol Metab 1:879-910.
Bergman RN, Yang YJ, Hope ID, Ader M (1990) The role of the transcapillary insulin transport in the efficiency of insulin action: studies with glucose clamps and the minimal model. Horm Metab Res 24:49-56.
Jansson P‐AE, Fowelin JP, Von Schenck HP, Smith UP, Lönnroth PN (1993) Measurement by microdialysis of the insulin concentration in subcutaneous interstitial fluid. Importance of the endothelial barrier for insulin. Diabetes 42:1469-1473.
Exton JH (1991) Some thoughts on the mechanism of action of insulin. Diabetes 40:521-526.
Moller DE, Flier JS (1991) Insulin resistance. Mechanisms, syndromes, and implications. N Engl J Med 325:938-948.
Moller DE Insulin Resistance, John Wiley, Chichester; 1993.
Reaven GM (1988) Role of insulin resistance in human disease. Diabetes 37:1595-1607.
Beck‐Nielsen H, Hother‐Nielsen O (1988) Insulin resistance. Diabetes Ann 4:565-591.
Scheen AJ, Castillo M, Lefèbvre PJ (1988) Insulin sensitivity in anorexia nervosa—a mirror image of obesity?. Diabetes/Metab Rev 4:681-690.
DeFronzo RA, Ferrannini E (1991) Insulin resistance: a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care 14:173-194.
Hollenbeck C, Reaven GM (1987) Variations in insulin‐stimulated glucose uptake in healthy individuals with normal glucose tolerance. J Clin Endocrinol Metab 64:1169-1173.
Rosenthal M, Haskel WL, Soloman R, Widstrom A, Reaven GM (1983) Demonstration of relationship between level of physical training and insulin‐stimulated glucose utilization in normal humans. Diabetes 32:408-411.
Lee A, Ader M, Bray GA, Bergman RN (1992) Diurnal variation in glucose tolerance. Cyclic suppression of insulin action and insulin secretion in normal‐weight, but not obese subjects. Diabetes 41:750-759.
Kahn CR (1978) Insulin resistance, insulin sensitivity, and insulin unresponsiveness: a necessary distinction. Metabolism 27:1893-1902.
Olefsky JM (1981) Insulin resistance and insulin action;. Diabetes 30:148-162.
Ferrannini E, De Fronzo RA (1992) Insulin actions in vivo: glucose metabolism. International Textbook of Diabetes Mellitus , Alberti KGMM, DeFronzo RA, Keen H, Zimmet P, John Wiley, Chichester; 409-438.
DeFronzo RA, Ferrannini E, Koivisto V (1983) New concepts in the pathogenesis and treatment of noninsulin‐dependent diabetes mellitus. Am J Med 75:52-81.
Reaven GM (1983) Insulin‐resistance in noninsulin‐dependent diabetes mellitus: does it exist and can it be measured?. Am J Med , (Suppl); 74:3-17.
Del Prato S, Ferrannini E, De Fronzo RA (1986) Evaluation of insulin sensitivity in man. Methods in Diabetes Research , Clark WL, Larner J, Pohl SL, Wiley, New York; 2:36-76.
Bergman RN, Hope ID, Yang YJ, Watanabe RM, Meador MA, Youn JH, Ader M (1989) Assessment of insulin sensitivity in vivo: a critical review. Diabetes/Metab Rev 5:411-429.
Fulcher GR, Walker M, Alberti KGMM (1992) The assesesment of insulin action in vivo. International Textbook of Diabetes Mellitus , Alberti KGMM, DeFronzo RA, Keen H, Zimmet P, John Wiley, Chichester; 513-529.
Scheen AJ, Lefèbvre PJ (1992) Assessment of insulin sensitivity in vivo. Application to the study of type 2 diabetes. Horm Res 38:19-27.
Groop LC, Widen E, Ferrannini E (1993) Insulin resistance and insulin deficiency in the pathogenesis of type 2 (non‐insulin‐dependent) diabetes mellitus: errors of metabolism or of methods?. Diabetologia 36:1326-1331.
Himsworth HP (1936) Diabetes mellitus. Its differentiation into insulin‐sensitive and insulin‐insensitive types. Lancet 1:127-130.
Lundbaek K (1962) Intravenous glucose tolerance as a tool in definition and diagnosis of diabetes mellitus. Br Med J 1:1507-1513.
Alford FP, Martin FIR, Pearson MJ (1971) The significance and interpretation of mildly abnormal oral glucose tolerance. Diabetologia 7:173-180.
Beck‐Nielsen H, Pedersen O, Lindskow HO (1979) Normalization of the insulin sensitivity and the cellular insulin binding during treatment of obese diabetics for one year. Acta Endocrinol (Copenh) 90:103-112.
Conard V (1955) Mesure de l'assimilation du glucose. Bases théoriques et applications cliniques. Acta Gastro‐Enterol Belg , 803, 845; 18:727-771.
Franckson JRM, Mesure de l'activité de l'insuline chez l'homme. PhD Thesis, University of Brussels, Brussels, Acta Med Belg; 1958.
Franckson JRM, Ooms HA, Bellens R, Conard V, Bastenie P (1962) Physiologic significance of the intravenous glucose tolerance test. Metabolism 11:482-500.
Franckson JRM, Malaisse W, Arnould Y, Rasio E, Ooms HA, Balasse E, Conard V, Bastenie PA (1966) Glucose kinetics in human obesity. Diabetologia 2:96-103.
Forbath N, Hetenyi G (1966) Glucose dynamics in normal subjects and diabetic patients before and after a glucose load. Diabetes 15:778-789.
Widen EIM, Eriksson JG, Ekstrand AV, Groop LC (1992) The relationship between first‐phase insulin secretion and glucose metabolism. Acta Endocrinol 127:289-293.
Bergman RN, Ider YZ, Bowden CR, Cobelli C (1979) Quantitative estimation of insulin sensitivity. Am J Physiol 236:E667.
Bergman RN, Phillips LS, Cobelli C (1981) Physiologic evaluation of factors controlling glucose tolerance in man. Measurement of insulin sensitivity and B‐cell glucose sensitivity from the response to intravenous glucose. J Clin Invest 68:1456-1467.
Yalow RS, Berson SA (1960) Plasma insulin concentrations in nondiabetic and early diabetic subjects. Determination by a new sensitive immunoassay technique. Diabetes 9:254-260.
Karam JH, Grodsky GM, Forsham PH (1963) Excessive insulin response to glucose in obese subjects as measured by immunochemical assay. Diabetes 12:197-204.
Reaven GM, Miller R (1968) Study of the relationship between glucose and insulin responses to an oral glucose load in man. Diabetes 17:560-569.
Steele R (1959) Influences of glucose loading and of injected insulin on hepatic glucose output. Ann NY Acad Sci 82:420-430.
De Bodo RC, Steele R, Altszuler N, Dunn A, Bishop JS (1963) On the hormonal regulation of carbohydrate metabolism: studies with 14C glucose. Recent Prog Horm Res 19:445-488.
Umpleby AM, Sönksen PH (1987) Measurement of the turnover of substrates of carbohydrate and protein metabolism using radioactive isotopes. Baillière's Clin Endocrinol Metab 1:773-796.
Vranic M (1992) Glucose turnover. A key to understanding the pathogenesis of diabetes (indirect effects of insulin). Diabetes 41:1188-1206.
(1984) Tracers in metabolic research. Radioisotope and stable isotope/mass spectrometry methods. Laboratory and Research Methods in Biology and Medicine , Wolfe RR, Alan R. Liss, New York; 9:1-287.
Radioactive and Stable Isotope Tracers in Biomedicine. Principles and Practice of Kinetics Analysis, Wolfe RR, Wiley‐Liss, New York; 1992.
Butler P, Bell P, Rizza R (1990) Choice and use of tracers;. Horm Metab Res , (Suppl); 24:20-25.
Overkamp D, Gautier JF, Renn W, Pickert A, Scheen AJ, Schmülling R‐M, Eggstein M, Lefèbvre PJ, Glucose turnover parameters in man in the basal state and after intravenous glucose: evaluation by two different tracer techniques. Am J Physiol Submitted.; .
Ferrannini E, Smith JD, Cobelli C, Toffolo G, Pilo A, De Fronzo RA (1985) Effect of insulin on the distribution and disposition of glucose in man. J Clin Invest 76:357-364.
Cobelli C, Mari A, Ferrannini E (1987) Non‐steady‐state: error analysis of Steele's model and developments for glucose kinetics. Am J Physiol 252:E679.
Bergman RN, Steil GM, Bradley DC, Watanabe RM (1992) Modeling of insulin action in vivo. Annu Rev Physiol 54:861-883.
Butler P, Caumo A, O'Brien P, Zerman A, Cobelli C, Rizza RA (1993) Methods for assessment of the rate of onset and offset of insulin action during nonsteady state in humans. Am J Physiol 264:E548.
Hother‐Nielsen O, Beck‐Nielsen H (1990) On the determination of basal glucose production rate in patients with type 2 (non‐insulin‐dependent) diabetes mellitus using primed‐continuous 3–3H‐glucose infusion. Diabetologia 33:603-610.
Radziuk J, Norwich KH, Vranic M (1978) Experimental validation of measurements of glucose turnover in nonsteady state. Am J Physiol 234:E84.
Argoud GM, Schade DS, Eaton RP (1987) Underestimation of hepatic glucose production by radioactive and stable tracers. Am J Physiol 252:E606.
McMahon MM, Schwenk WF, Haymond MW, Rizza RA (1989) Underestimation of glucose turnover measured with [6–3H]‐ and [6,6–2H2]‐but not [6–14C]glucose during hyperinsuline‐mia in humans. Diabetes 38:97-107.
Pedersen B, Moller N, Nielsen OH, Schmitz O (1989) Contamination of tritiated glucose tracers. Diabète Metab 15:102-103.
Butler PC, Kryshak EJ, Schwenk WF, Haymond MW, Rizza RA (1990) Hepatic and extrahepatic responses to insulin in NIDDM and nondiabetic humans: assessment in absence of artifact introduced by tritiated nonglucose contaminants. Diabetes 39:217-225.
Neely RDG, Rooney DP, Atkinson AB, Sheridan B, Ennis CN, Trimble ER, Bell PM (1990) Underestimation of glucose turnover determined using [6–3H] glucose tracer in non‐steady state: the role of a tritiated tracer impurity. Diabetologia 33:681-687.
Finegood DT, Bergman RG, Vranic M (1988) Modeling error and apparent isotope discrimination confound estimation of endogenous glucose production during euglycemic clamps. Diabetes 37:1025-1034.
Yki‐Järvinen H, Consoli A, Nurjhan N, Young AA, Gerich JE (1989) Mechanism for the underestimation of isotopically determined glucose disposal. Diabetes 38:744-751.
Molina JM, Baron AD, Edelman SV, Brechtel G, Wallace P, Olefsky JM (1990) Use of a variable tracer infusion method to determine glucose turnover in humans. Am J Physiol 258:E16.
Schwenk WF, Butler PC, Haymond MW, Rizza RA (1990) Underestimation of glucose turnover corrected with high‐performance liquid chromatography purification of [6–3H]‐glucose. Am J Physiol 258:E228.
Katz H, Butler P, Homan M, Zerman A, Caumo A, Cobelli C, Rizza R (1993) Hepatic and extrahepatic insulin action in humans: measurement in the absence of non‐steady‐state error. Am J Physiol 264:E561.
Levy JC, Brown G, Matthews DR, Turner RC (1989) Hepatic glucose output in humans measured with labelled glucose to reduce negative errors. Am J Physiol 257:E531.
Cobelli C, Toffolo G (1990) Constant specific activity input allows reconstruction of endogenous glucose concentration in non‐steady state. Am J Phsyiol 258:E1037.
Hother‐Nielsen O, Mengel A, Moller J, Rasmussen O, Schmitz O, Beck‐Nielsen H (1992) Assessment of glucose turnover rates in euglycaemic clamp studies using primed‐constant [3–3H]‐glucose infusion and labelled or unlabelled glucose infusates. Diabetic Medicine 9:840-849.
Ader M, Bergman RN (1990) Peripheral effects of insulin dominate suppression of fasting hepatic glucose production. Am J Physiol 258:E1020.
Ferrannini E, Björkman O, Reichard GA, Wahren J, Pilo A, Olsson M, De Fronzo RA (1985) The disposal of an oral glucose load in healthy subjects. A quantitative study. Diabetes 34:580-588.
Kelley O, Mitrakou A, Marsh H, Schwenk L, Benn J, Sonnenbverg G, Arcangeli M, Aoki T, Sorensen J, Berger M, Sönksen P, Gerich J (1988) Skeletal muscle glycolysis, oxidation, and storage of an oral glucose load. J Clin Invest 81:1563-1571.
DeFronzo RA, Bonadonna RC, Ferrannini E (1992) Pathogenesis of NIDDM. A balanced overview. Diabetes Care 15:318-368.
Butler PC, Home PD (1987) The measurement of metabolite exchange across muscle beds. Baillière's Clin Endocrinol Metab 1:863-878.
DeFronzo RA (1987) Use of the splanchnic/hepatic balance technique in the study of glucose metabolism. Baillière's Clin Endocrinol Metab 1:837-862.
Andres R, Cader G, Zierler KL (1956) The quantitatively minor role of carbohdyrate in oxidative metabolism by skeletal muscle in intact man in the basal state. Measurements of oxygen and glucose uptake and carbon dioxide and lactate production in forearm. J Clin Invest 35:671-682.
Zierler KL (1961) Theory of the use of arteriovenous concentration differences for measuring metabolism in steady and non‐steady states. Journal of Clinical Investigation 40:2111-2125.
Marin P, Rebuffe‐Scrive M, Smith U, Bjömtorp P (1987) Glucose uptake in human adipose tissue. Metabolism 36:1154-1160.
DeFronzo RA, Jacot E, Jéquier E, Maeder E, Wahren J, Felber J‐P (1981) The effect of insulin on the disposition of intravenous glucose. Results from indirect calorimetry and hepatic and femoral venous catheterization. Diabetes 30:1000-1007.
Rabinowitz D, Zierler KL (1962) Forearm metabolism in obesity and its response to intraarterial insulin. Characterization of insulin resistance and evidence for adaptive hyperinsulinemia. J Clin Invest 41:2173-2181.
Butterfield WJH, Whichelow MJ (1965) Peripheral glucose metabolism in control subjects and diabetic patients during glucose, glucose–insulin, and insulin sensitivity tests. Diabetologia 1:43-53.
Jackson RA, Perry G, Rogers J, Advoni U, Pilkington TRE (1973) Relationship between the basal glucose concentration, glucose tolerance, and forearm glucose uptake in maturity onset diabetes. Diabetes 22:751-761.
Kalant N, Leibovici D, Fukushima J, Ozaki S (1982) Insulin responsiveness of superficial forearm tissues in type 2 (non‐insulin‐dependent) diabetes. Diabetologia 22:239-244.
DeFronzo R, Gunnarsson R, Björkman O, Olsson M, Wahren J (1985) Effects of insulin on peripheral and splanchnic glucose metabolism in non‐insulin dependent (type II) diabetes mellitus. J Clin Invest 76:149-155.
Mitrakou A, Kelley D, Veneman T, Jensen T, Pangburn T, Reilly J, Gerich J (1990) Contribution of abnormal muscle and liver glucose metabolism to post‐prandial hyperglycemia in NIDDM. Diabetes 39:1381-1390.
Kelley DE, Mokan M, Mandarino LJ (1993) Metabolic pathways of glucose in skeletal muscle of lean NIDDM. Diabetes Care 16:1158-1166.
DelPrato S, Bonadonna RC, Bonora E, Gulli G, Solini A, Shank M, DeFronzo RA (1993) Characterization of cellular defects in insulin action in type 2 (non‐insulin‐dependent) diabetes mellitus. Journal of Clinical Investigation 91:484-494.
Yki‐Järvinen H, Young A, Lamkin C, Foley JE (1987) Kinetics of glucose disposal in whole body and across the forearm in man. Journal of Clinical Investigation 79:1713-1719.
Cobelli C, Saccomani MP, Ferrannini E, De Fronzo RA, Gelfand R, Bonadonna R (1989) A compartmental model to quantitate in vivo glucose transport in the human forearm. Am J Physiol 257:E943.
Bonadonna RC, Saccomani MP, Seely L, Zych KS, Ferrannini E, Cobelli C, DeFronzo RA (1993) Glucose transport in human skeletal muscle. The in vivo response to insulin. Diabetes 42:191-198.
Wahren J, Felig P (1971) Influence of endogenous insulin secretion on splanchnic glucose and amino acid metabolism. J Clin Invest 50:1702-1709.
Katz LD, Glickman MG, Rapoport S, Ferrannini E, DeFronzo RA (1983) Splanchnic and peripheral glucose disposal of oral glucose load in man. Diabetes 32:675-679.
DeFronzo RA, Ferrannini E, Hendler R, Felig P, Wahren J (1983) Regulation of splanchnic and peripheral glucose uptake by insulin and hyperglycemia in man. Diabetes 32:35-45.
DeFronzo RA, Ferrannini E (1987) Regulation of hepatic glucose metabolism in humans. Diabetes/Metab Rev 3:415-459.
Ferrannini E, Groop LC (1989) Hepatic glucose production in insulin‐resistant states. Diabetes/Metab Rev 5:711-725.
Shen SW, Reaven GM, Farquhar JW (1970) Comparison of impedance to insulin‐mediated glucose uptake in normal subjects and in subjects with latent diabetes. J Clin Invest 49:2151-2160.
Harano Y, Ohgaku S, Hidaka H, Haneda M, Kikkawa R, Shigeta Y, Abe H (1977) Glucose, insulin and somatostatin infusion for the determination of insulin sensitivity. J Clin Endocrinol Metab 45:1124-1127.
Reaven GM, Bernstein R, Davis B, Olefsky JM (1976) Nonketotic diabetes mellitus: insulin deficiency or insulin resistance?. Am J Med 60:80-88.
Nagulesparan M, Savage PJ, Unger RH, Bennett PH (1979) A simplified method using somatostatin to assess in vivo insulin resistance over a range of obesity. Diabetes 28:980-983.
Ratzmann KP, Besch W, Witt S, Schulz B (1981) Evaluation of insulin resistance during inhibition of endogenous insulin and glucagon secretion by somatostatin in non‐obese subjects with impaired glucose tolerance. Diabetologia 21:192-197.
Harano Y, Ohgaku S, Kosugi K, Yasuda H, Nakono T, Kobayashi M, Hidaka H, Izumi K, Kashiwagi A, Shigeta Y (1981) Clinical significance of altered insulin sensitivity in diabetes mellitus assessed by glucose, insulin, and somatostatin infusion. J Clin Endocrinol Metab 52:982-987.
Ho LT, Chang ZY, Wang JT, Liu YF, Chen Y‐DI, Reaven GM (1990) Insulin insensitivity in offspring of parents with type 2 diabetes mellitus. Diabetic Med 7:31-34.
Greenfield MS, Doberne L, Kraemer F, Tobey T, Reaven G (1981) Assessment of insulin resistance with the insulin suppression test and the euglycemic clamp. Diabetes 30:387-392.
Heine RJ, Home PD, Ponchner M, Orskov H, Hammond V, McCulloch AJ, Hanning I, Alberti KGMM (1985) A comparison of 3 methods for assessing insulin sensitivity in subjects with normal and abnormal glucose tolerance. Diabetes Res 2:113-120.
Heine RJ, Bilo HJG, Van der Meer J, Van der Veen EA (1986) Sequential infusions of glucose and insulin at prefixed rates: a simple method for assessing insulin sensitivity and insulin responsiveness. Diabetes Res 3:453-461.
Leslie RDG, Ganash A, Volkmann HP, Hanning L, Alberti KGMM (1988) Insensitivity to insulin in offspring of non‐insulin dependent diabetic patients. Diab Nutr Metab 3:235-237.
Nagi DK, Yudkin JS (1990) The reproducibility of the insulin sensitivity test (IST) without pancreatic suppression (modified Harano technique) as an index of insulin resistance in non‐insulin‐dependent diabetic subjects. Diabetic Med , Suppl; 7(2):P19.
Andres R, Swerdloff R, Pozefsky T, Coleman D (1966) Manual feedback technique for the control of blood glucose concentration. Automation in Analytical Chemistry , Skeggs LT Jr, Mediad, New York; 486-491.
Sherwin RS, Kramer KJ, Tobin JD, Insel PA, Liljenquist JE, Berman M, Andres R (1974) A model of the kinetics of insulin in man. J Clin Invest 53:1481-1492.
Insel PA, Liljenquist JE, Tobin JD, Sherwin RS, Watkins P, Andres R, Berman M (1975) Insulin control of glucose metabolism in man. A new kinetics study. J Clin Invest 55:1057-1066.
DeFronzo RA, Tobin JD, Andres R (1979) Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 232:E214.
Chen Y‐DI, Golay A, Swislocki ALM, Reaven GM (1987) Resistance to insulin suppression of plasma free fatty acid concentration and insulin stimulation of glucose uptake in noninsulin‐dependent diabetes mellitus. J Clin Endocrinol Metab 64:17-21.
Groop LC, Bonadonna RC, DelPrato S, Ratheiser K, Zyck K, Ferrannini E, DeFronzo RA (1989) Glucose and free fatty acid metabolism in non‐insulin‐dependent diabetes mellitus: evidence for multiple sites of insulin resistance. J Clin Invest 84:205-213.
Verdonk CA, Rizza RA, Westland RE, Nelson RL, Gerich JE, Service FJ (1980) Glucose clamping using the Biostator GCIIS. Horm Metab Res 12:133-135.
Ponchner M, Heine RJ, Pernet A, Hanning I, Francis AJ, Cook D, Orskov H, Alberti KGMM (1984) A comparison of the artificial pancreas (glucose controlled insulin infusion system) and a manual technique for assessing insulin sensitivity during euglycaemic clamping. Diabetologia 26:420-425.
Pacini G, Finegood DT, Bergman RN (1982) A minimal‐model‐based glucose clamp yielding insulin sensitivity independent of glycemia. Diabetes 31:432-441.
Pacini G, Bergman RN (1983) PACBERG: an adaptive program to control the blood sugar. Comput Programs Biomed 16:13-20.
Matthews DR, Hosker JP (1989) Unbiased and flexible computer program to achieve glucose clamping. Diabetes Care 12:156-159.
Andrews J, Klimes L, Vasquez B, Nagulesparan M, Reaven GM (1984) Can mixed venous blood be used to measure insulin action during the hyperinsulinemic clamp?. Horm Metab Res , (Suppl); 16:164-166.
McGuire EAH, Helderman JH, Tobin JD, Andres R, Berman M (1976) Effects of arterial versus venous sampling on analysis of glucose kinetics in man. J Appl Physiol 41:565-573.
Best JD, Alford FP, Martin IK, Pestell RG, Ward GM (1990) Practical application of methods for in vivo assessment of insulin secretion and action. Horm Metab Res 24:60-66.
Liu G, Chen YDI, Hollenbeck CB, Lardinois CK, Reaven GM (1984) Insulin‐stimulated glucose disposal increases with time in patients with non‐insulin dependent diabetes mellitus. Diabetes 33:643-647.
Doberne L, Greenfield MS, Rosenthal M, Widstrom A, Reaven G (1982) Effect of variations in basal plasma glucose concentration on glucose utilization (M) and metabolic clearance (MCR) rates during insulin clamp studies in patients with non‐insulin‐dependent diabetes mellitus. Diabetes 31:396-400.
Best JD, Taborsky GJ, Halter JB, Porte D (1981) Glucose disposal is not proportional to plasma glucose level in man. Diabetes 30:847-850.
Verdonk CA, Rizza RA, Gerich JE (1981) Effects of plasma glucose concentration on glucose utilization and glucose clearance in normal man. Diabetes 30:535-537.
DeFronzo RA, Ferrannini E (1982) Influence of plasma glucose and insulin concentration on plasma glucose clearance in man. Diabetes 31:683-688.
Proietto J, Nankervis A, Aitken P, Caruso G, Harewood M, Alford FP (1983) The physiological action of insulin on glucose uptake and its relevance to the interpretation of the metabolic clearance rate of glucose. Metabolism 32:1022-1028.
Gottesman I, Mandarino L, Gerich J (1984) Use of glucose uptake and glucose clearance for the evaluation of insulin action in vivo. Diabetes 33:184-191.
Radziuk J, Lickley HLA (1985) The metabolic clearance rate of glucose: measurement and meaning. Diabetologia 28:315-322.
Donner CC, Fraze E, Chen YDI, Hollenbeck CB, Foley JE, Reaven GM (1985) Presentation of a new method for specific measurement of in vivo insulin‐stimulated glucose disposal in humans: comparison of this approach with the insulin clamp and minimal model techniques. J Clin Endocrinol Metab 60:723-726.
Prager R, Wallace P, Olefsky J (1986) In vivo kinetics of insulin action on peripheral glucose disposal and hepatic glucose output in normal and obese subjects. J Clin Invest 78:472-481.
Doeden B, Rizza R (1987) Use of variable insulin infusion to assess insulin action in obesity: defects in both the kinetics and amplitude of response. J Clin Endocrinol Metab 64:902-908.
Doeden B, Rizza R (1988) Insulin action in insulin‐dependent diabetes mellitus (type I): measurement during constant and changing insulin concentrations. J Lab Clin Med 112:28-35.
Edelman SV, Laakso M, Wallace P, Brechtel G, Olefsky JM, Baron AD (1990) Kinetics of insulin‐mediated and non‐insulin‐mediated glucose uptake in humans. Diabetes 39:955-964.
Laakso M, Edelman SV, Olefsky JM, Brechtel G, Wallace P, Baron AD (1990) Kinetics of in vivo muscle insulin‐mediated glucose uptake in human obesity. Diabetes 39:965-974.
Jandrain B, Scheen AJ, Henrivaux P, Paolisso G, Luyckx AS, Lefèbvre PJ (1985) Insulin sensitivity and glucose tolerance during the menstrual cycle. Metabolic Complications of Human Obesities , ICS No. 682, Vague J, Björntorp P, Guy‐Grand B, Rebuffé‐Scrive M, Vague P, Excerpta Medica, Amsterdam; 241-247.
Scheen AJ, Etude quantitative de la sécrétion, de l'action et du métabolisme de l'insuline. Modèle de régulation glycémique chez le sujet normal, obèse et diabétique. PhD Thesis, University of Liège, Belgium; 1991.
Gin H, Brunei PG, Brother E, Aubertin J, Drouin P, Debry G (1984) Etude de la faisabilité et de la reproductibilité d'une technique de clamp euglycémique hyperinsulinémique. Diabète Metab 10:36-38.
Elahi D, Meneilly GS, Minaker KL, Andersen DK, Rowe JW (1989) Escape of hepatic glucose production during hyperglycemic clamp. Am J Physiol 257:E704.
Mitrakou A, Vuorinen‐Markkola H, Raptis G, Toft I, Mokan M, Strumph P, Pimenta W, Veneman T, Jenssen T, Bolli G, Korytkowski M, Yki‐Järvinen H, Gerich J (1992) Simultaneous assessment of insulin secretion and insulin sensitivity using a hyperglycemic clamp. J Clin Endocrinol Metab 75:379-382.
Baron AD, Brechtel G, Wallace P, Edelman SV (1988) Rates and tissue sites of non‐insulin‐ and insulin‐mediated glucose uptake in humans. Am J Physiol 255:E769.
Baron AD, Koltermann OG, Bell J, Mandarino LJ, Olefsky JM (1985) Rates of noninsulin‐mediated glucose uptake are elevated in type II diabetic subjects. J Clin Invest 76:1782-1788.
Ferrannini E, Locatelli L, Jéquier E, Felber JP (1989) Differential effects of insulin and hyperglycemia on intracellular glucose disposition in humans. Metabolism 38:459-465.
Thorburn AW, Gumbiner B, Brechtel G, Henry RR (1990) Effect of hyperinsulinemia and hyperglycemia on intracellular glucose and fat metabolism in healthy volunteers. Diabetes 39:22-30.
Gottesman I, Mandarino L, Verdonk C, Rizza R, Gerich J (1982) Insulin increases the maximum velocity for glucose uptake without altering the Michaelis constant in man. Evidence that insulin increases glucose uptake merely by providing additional transport sites. J. Clin Invest 70:1310-1314.
Gelfand RA, DeFronzo RA (1984) Hypoglycemic counterregulation in normal and diabetic man. Ann Clin Res 16:84-93.
Mitrakou A, Ryan C, Veneman T, Mokan M, Jenssen T, Kiss I, Durrant J, Cryer P, Gerich J (1991) Hierarchy of glycemic thresholds for counterregulatory hormone secretion, symptoms, and cerebral dysfunction. Am J Physiol 260:E67.
Kraegen EW, Chisholm DJ (1984) Insulin responses to varying profiles of subcutaneous insulin infusion: kinetic modelling studies. Diabetologia 26:208-213.
Jackson RA, Hamling JB, Blix PM, Sim BM, Hawa MI, Jaspan JB, Belin J, Nabarro JDN (1986) The influence of graded hyperglycemia with and without physiologic hyperinsulinemia on forearm glucose uptake and other metabolic responses in man. J Clin Endocrinol Metab 63:594-604.
Ebeling P, Bourey R, Koranyi L, Tuominen JA, Groop LC, Henriksson J, Mueckler M, Sovijärvi A, Koivisto VA (1993) Mechanism of enhanced insulin sensitivity in athletes. Increased blood flow, muscle glucose transport protein (GLUT‐4) concentration, and glycogen synthase activity. Journal of Clinical Investigation 92:1623-1631.
Yki‐Järvinen H, Puhakainen I, Koivisto VA (1991) Effect of free fatty acids on glucose uptake and nonoxidative glycolysis across human forearm tissues in the basal state and during insulin stimulation. The Journal of Clinical Endocrinology & Metabolism 72:1268-1277.
Yki‐Järvinen H, Sahlin K, Ren JM, Koivisto VA (1990) Localization of rate‐limiting defect for glucose disposal in skeletal muscle of insulin‐resistant type 1 diabetic patients. Diabetes 39:157-167.
Ferrannini E, Katz LD, Glickman MG, DeFronzo RA (1990) Influence of combined intravenous and oral glucose administration on splanchnic glucose uptake in man. Clin Physiol 10:527-538.
Jéquier E, Felber JP (1987) Indirect calorimetry. Baillière's Clinical Endocrinology and Metabolism 1:911-935.
Jéquier E, Acheson K, Schutz Y (1987) Assessment of energy expenditure and fuel utilization in man. Annu Rev Nutr 7:1187-1208.
Ferrannini E (1988) The theoretical bases of indirect calorimetry: a review. Metabolism 37:287-301.
Simonson DC, DeFronzo RA (1990) Indirect calorimetry: methodological and interpretative problems. Am J Physiol 258:E399.
McMahon MM, Marsh HM, Rizza RA (1991) Comparison of extracellular and net glucose oxidation measured isotopically and by indirect calorimetry during high and low glucose turnover. Am J Clin Nutr 53:1138-1142.
Felber JP, Ferrannini E, Golay A, Meyer HU, Thiébaud D, Curchod B, Maeder E, Jéquier E, DeFronzo RA (1987) Role of lipid oxidation in pathogenesis of insulin resistance of obesity and type II diabetes. Diabetes 36:1341-1350.
Felber JP, Haesler E, Jéquier E (1993) Metabolic origin of insulin resistance in obesity with and without type 2 (non‐insulin‐dependent) diabetes mellitus. Diabetologia 36:1221-1229.
Taylor R (1987) Use of adipose tissue for metabolic studies. Baillière's Clin Endocrinol Metab 1:1023-1025.
Agius L (1987) Human liver in vitro techniques for metabolic studies. Baillière's Clin Endocrinol Metab 1:999-1021.
Häring H, Obermaier‐Kusser B (1989) Insulin receptor kinase defects in insulin‐resistant tissues and their roles in the pathogenesis of NIDDM. Diabetes / Metabolism Reviews 5:431-441.
Nyomba BL, Ossowski VM, Saad MF, Bogardus C, Mott DM (1992) Tyrosine kinase activity of skeletal muscle during insulin infusion in humans. J. Clin Endocrinol Metab 75:218-223.
Garvey WT, Kolterman OG (1988) Correlation of in vivo and in vitro actions of insulin in obesity and noninsulin‐dependent diabetes mellitus: role of the glucose transport system. Diabetes / Metabolism Reviews 4:543-569.
Klip A, Paquet MR (1990) Glucose transport and glucose transporters in muscle and their metabolic regulation. Diabetes Care 13:228-243.
Bogardus C, Lillioja S, Stone K, Mott D (1984) Correlation between muscle glycogen synthase activity and in vivo insulin action in man. J Clin Invest 73:1185-1190.
Yki‐Järvinen H, Mott D, Young AA, Stone K, Bogardus C (1987) Regulation of glycogen synthase and phosphorylase activities by glucose and insulin in human skeletal muscle. Journal of Clinical Investigation 80:95-100.
Mandarino LJ (1989) Regulation of skeletal muscle pyruvate dehydrogenase and glycogen synthase in man. Diabetes/Metab Rev 5:475-486.
Kelley DE, Mokan M, Mandarino LJ (1992) Intracellular defects in glucose metabolism in obese patients with NIDDM. Diabetes 41:698-706.
Lönnroth P, Smith U (1990) Microdialysis—a novel technique for clinical investigations. Journal of Internal Medicine 227:295-300.
Arner P, Bülow J (1993) Assessment of adipose tissue metabolism in man: comparison of Fick and microdialysis techniques. Clin Sci 85:247-256.
Hagström‐Toft E, Arner P, Nälund B, Ungerstedt U, Bolinder J (1991) Effects of insulin deprivation and replacement on in vivo subcutaneous adipose tissue substrate metabolism in humans. Diabetes 40:666-671.
Jansson PA, Fowelin J, Smith U, Lönnroth P (1988) Characterization by microdialysis of intercellular glucose level in subcutaneous tissue in humans. Am J Physiol 255:218-220.
Hagström‐Toft E, Arner P, Johansson U, Eriksson LS, Ungerstedt U, Bolinder J (1992) Effect of insulin in human adipose tissue metabolism in situ. Interactions with beta‐adrenoceptors. Diabetologia 35:664-670.
Gottesman I, Mandarino L, Gerich J (1983) Estimation and kinetic analysis of insulin‐independent glucose uptake in human subjects. Am J Physiol 244:E632.
Rizza R, Mandarino L, Gerich J (1981) Dose–response characteristics for the effects of insulin on production and utilization of glucose in man. Am J Physiol 240:E630.
Proietto J, Harewood M, Aitken P, Nankervis A, Caruso G, Alford F (1982) Validation of a practical in vivo insulin dose–response curve in man. Metabolism 31:354-360.
Thiebaud D, Jacot E, DeFronzo R, Maeder E, Jéquier E, Felber JP (1982) The effect of graded doses of insulin on total glucose uptake, glucose oxidation, and glucose storage in man. Diabetes 31:957-963.
Mikines KJ, Sonne B, Farrell PA, Tronier B, Galbo H (1989) Effect of training on the dose–response relationship for insulin action in men. J Appl Physiol 66:695-703.
Kolterman O, Insel J, Salkow M, Olefsky J (1980) Mechanisms of insulin resistance in human obesity: evidence for receptor and postreceptor defects. J Clin Invest 65:1272-1284.
Olefsky JM, Kolterman OG, Scarlett JA (1982) Insulin action and resistance in obesity and noninsulin‐dependent type II diabetes mellitus. Am J Physiol 243:E15.
Bonadonna RC, Groop L, Kraemer N, Ferrannini E, DelPrato S, DeFronzo RA (1990) Obesity and insulin resistance in humans: a dose–response study. Metabolism 39:452-459.
Kolterman O, Gray R, Griffin J, Burstein P, Insel J, Scarlett J, Olefsky J (1981) Receptor and postreceptor defects contribute to the insulin resistance of noninsulin‐dependent diabetes mellitus. J Clin Invest 68:957-969.
Rizza R, Mandarino L, Gerich J (1981) Mechanism and significance of insulin resistance in noninsulin‐dependent diabetes mellitus. Diabetes 30:990-995.
Campbell PJ, Mandarino LJ, Gerich JE (1988) Quantification of the relative impairment in actions of insulin on hepatic glucose production and peripheral glucose uptake in non‐insulin‐dependent diabetes mellitus. Metabolism 37:15-21.
Ader M, Poulin RA, Yang YJ, Bergman RN (1992) Dose–response relationship between lymph insulin and glucose uptake reveals enhanced insulin sensitivity of peripheral tissues. Diabetes 41:241-253.
Scheen AJ, Paolisso G, Salvatore T, Lefèbvre PJ (1991) Improvement of insulin‐induced glucose disposal in obese patients with NIDDM after 1‐week treatment with fenfluramine. Diabetes Care 14:325-332.
Carson ER, Cobelli C, Finkelstein L The Mathematical Modeling of Metabolic and Endocrine Systems, Wiley, New York; 1983.
Carbohydrate Metabolism. Quantitative Physiology and Mathematical Modelling, Cobelli C, Bergman RN, (Eds):, John Wiley, Chichester; 1981.
Bergman RN, Cobelli C (1980) Minimal modeling, partition analysis, and the estimation of insulin sensitivity. Fed Proc 39:110-115.
Ng LL (1988) Application of modelling techniques to the assessment of insulin sensitivity in man. Diabetic Med 5:217-222.
Ng LL, Coppack SW, Zhang L, Hockaday TDR (1990) Application of minimal models to measuring insulin sensitivity. Horm Metabol Res 24:57-59.
Bergman RN (1989) Towards physiological understanding of glucose tolerance. Minimal‐model approach. Diabetes 38:1512-1527.
Cobelli C, Bier DM, Ferrannini E (1990) Modeling glucose metabolism in man: theory and practice. Horm Metab Res , (Suppl); 24:1-10.
Temple RC, Clark PMS, Hales CN (1992) Measurement of insulin secretion in type 2 diabetes: problems and pitfalls. Diabetic Med 9:503-512.
Turner RC, Holman RR, Matthews D, Hockaday TDR, Peto J (1979) Insulin deficiency and insulin resistance interaction in diabetes: estimation of their relative contribution by feedback analysis from basal plasma insulin and glucose concentrations. Metabolism 28:1086-1096.
Turner RC, Rudenski AS, Matthews DR, Levy JC, O'Rahilly SP, Hosker JP (1990) Application of structural model of glucose‐insulin relations to assess beta‐cell function and insulin sensitivity. Horm Metab Res , (Suppl); 24:66-71.
Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC (1985) Homeostasis model assessment: insulin resistance and B‐cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412-419.
(1988) V. Characteristics of newly presenting type 2 diabetic patients: estimated insulin sensitivity and islet B‐cell function. Diabetic Med 5:444-448.
Dowse GK, Qin H, Collins VR, Zimmet PZ, Alberti KGMM, Gareeboo H (1990) Determinants of estimated insulin resistance and B‐cell function in Indian, Creole and Chinese Mauritians. The Mauritius NCD Study Group. Diabetes Res Clin Pract 10:265-279.
Turner RC, Holman RR, Matthews DR, Peto J (1982) Relative contributions of insulin deficiency and insulin resistance in maturity‐onset diabetes. Lancet 1:596-598.
Rudenski AS, Hadden DR, Atkinson AB, Kennedy L, Matthews DR, Merrett JD, Pockaj B, Turner RC (1988) Natural history of pancreatic islet B‐cell function in type 2 diabetes mellitus studied over six years by homeostasis model assessment. Diabetic Med 5:36-41.
Rudenski AS, Matthews DR, Levy JC, Turner RC (1991) Understanding “insulin resistance”: both glucose resistance and insulin resistance are required to model human diabetes. Metabolism 40:908-917.
Reaven GM, Farquhar JW (1969) Steady state plasma insulin response to continuous glucose infusion in normal and diabetic subjects. Diabetes 18:273-279.
Hosker JP, Matthews DR, Rudenski AS, Burnett MA, Darling P, Bown EG, Turner RC (1985) Continuous infusion of glucose with model assessment: measurement of insulin resistance and B‐cell function in man. Diabetologia 28:401-411.
Hosker JP, Burnett MA, Matthews DR, Turner RC (1993) Prednisolone enhances B‐cell function independently of ambient glycemic levels in type II diabetes. Metabolism 42:1116-1120.
O'Rahilly SP, Nugent Z, Rudenski AS, Hosker JP, Burnett MA, Darling P, Turner RC (1986) Beta‐cell dysfunction, rather than insulin insensitivity, is the primary defect in familial type 2 diabetes. Lancet 2:360-363.
Cook JTE, Page RCL, Levy JC, Hammersley MS, Walravens EKN, Turner RC (1993) Hyperglycaemic progression in subjects with impaired glucose tolerance: association with decline in beta cell function. Diabetic Med 10:321-326.
Pacini G, Bergman RN (1986) MINMOD: a computer program to calculate insulin sensitivity and pancreatic responsivity from the frequently sampled intravenous glucose tolerance test. Comput Methods Programs Biomed 23:113-122.
Martin IK, Weber KM, Ward GM, Best JD, Boston RC (1990) Application of the SAAM modeling program to minimal model analysis of intravenous glucose tolerance test data. Comput Methods Programs Biomed 33:193-203.
Vega‐Catalan FJ (1990) A program to estimate insulin sensitivity and pancreatic responsivity from an IVGTT using the minimal modeling technique. Computers and Biomedical Research 23:1-9.
Duysinx BC, Scheen AJ, Gérard PL, Letiexhe M, Paquot N, Lefèbvre PJ (1994) Measurement of insulin sensitivity by the minimal model method using a simplified intravenous glucose tolerance test: validity and reproducibility. Diabete Metab 20.
Ader M, Pacini G, Yang YJ, Bergman RN (1985) Importance of glucose per se to intravenous glucose tolerance. Comparison of the minimal‐model prediction with direct measurements. Diabetes 34:1092-1103.
Steil GM, Bergman RN (1991) Reduced sampling for the minimal model estimate of insulin sensitivity from the modified and standard frequently sampled IVGTT (Abstract). Diabetes , Suppl; 40(1):38A.
Steil GM, Volund A, Kahn SE, Bergman RN (1993) Reduced sample number for calculation of insulin sensitivity and glucose effectiveness from the minimal model. Suitability for use in population studies. Diabetes 42:250-256.
Coates PA, Ollerton RL, Luzio SD, Ismail IS, Owens DR (1993) Reduced sampling protocols in estimation of insulin sensitivity and glucose effectiveness using the minimal model in NIDDM. Diabetes 42:1635-1641.
Cutfield WS, Bergman RN, Menon RK, Sperling MA (1990) The modified minimal model: application to measurement of insulin sensitivity in children. J Clin Endocrinol Metab 70:1644-1650.
Kahn SE, Prigeon RL, McCullog DK, Boyko EJ, Bergman RN, Schwartz MW, Neifing JL, Ward WK, Beard JC, Palmer JP, Porte D (1993) Quantification of the relationship between insulin sensitivity and B‐cell function in human subjects. Evidence for a hyperbolic function. Diabetes 42:1663-1672.
Beard JC, Ward WK, Halter JB, Wallum BJ, Porte D (1987) Relationship of islet function to insulin action in human obesity. J Clin Endocrinol Metab 65:59-64.
Weber KM, Martin IK, Best JD, Alford FP, Boston RC (1989) Alternative method for minimal model analysis of intravenous glucose tolerance data. Am J Physiol 256:E524.
Beard JC, Bergman RN, Ward WK, Porte D (1986) The insulin sensitivity index in nondiabetic man. Correlation between clamp‐derived and IVGTT‐derived values. Diabetes 35:362-369.
Yang YJ, Youn JH, Bergman RN (1987) Modified protocols improve insulin sensitivity estimation using the minimal model. Am J Physiol 253:E595.
Finegood DT, Hramiak IM, Dupre J (1990) A modified protocol for estimation of insulin sensitivity with the minimal model of glucose kinetics in patients with insulin‐dependent diabetes. J Clin Endocrinol Metab 70:1538-1549.
Welch S, Gebhart SSP, Bergman RN, Phillips LS (1990) Minimal model analysis of intravenous glucose tolerance test‐derived insulin sensitivity in diabetic subjects. J Clin Endocrinol Metab 71:1508-1518.
Ward GM, Weber KM, Walters IM, Aitken PM, Lee B, Best JD, Boston RC, Alford FP (1991) A modified minimal model analysis of insulin sensitivity and glucose‐mediated glucose disposal in insulin‐dependent diabetes. Metabolism 40:4-9.
Cobelli C, Pacini G, Toffolo G, Sacca L (1986) Estimation of insulin sensitivity and glucose clearance from minimal model: new insights from labelled IVGTT. Am J Physiol 250:E591.
Avogaro A, Bristow JD, Bier DM, Cobelli C, Toffolo G (1989) Stable‐label intravenous glucose tolerance test minimal model. Diabetes 38:1048-1055.
Caumo A, Giacca A, Morgese M, Pozza G, Micossi P, Cobelli C (1991) Minimal models of glucose disappearance: lessons from the labelled IVGTT. Diabetic Med 8:822-832.
Foley JE, Chen YDI, Lardinois CK, Hollenbeck CB, Liu GC, Reaven GM (1985) Estimates of in vivo insulin action in humans: comparison of the insulin clamp and the minimal model techniques. Horm Metab Res 17:406-409.
Bergman RN, Prager R, Volund A, Olefsky JM (1987) Equivalence of insulin sensitivity index in man derived by the minimal model method and the euglycemic glucose clamp. J Clin Invest 79:790-800.
Korytkowski M, Berga S, Horwitz M (1993) Comparison of the minimal model and hyperglycemic clamp techniques for measuring insulin sensitivity. Diabetes , Suppl; 42(1):169A.
Marchesini G, Pacini G, Bianchi G, Patrono D, Cobelli C (1990) Glucose disposal, B‐cell secretion, and hepatic insulin extraction in cirrhosis: a minimal model assessment. Gastroenterology 99:1715-1722.
Ward GM, Walters JM, Aitken PM, Best JD, Alford FP (1990) Effects of prolonged pulsatile hyperinsulinemia in humans. Enhancement of insulin sensitivity. Diabetes 39:501-507.
Pestell R, Alford F, Ramos R, Sawyer S, Best J, Ward G (1990) Insulin secretion, insulin sensitivity and glucose‐mediated disposal in thyrotoxicosis: a minimal model analysis. Clin Endocrinol 33:481-493.
Johnston C, Ward WK, Beard JC, McKnight B, Porte D (1990) Islet function and insulin sensitivity in the non‐diabetic offspring of conjugal type 2 diabetic patients. Diabetic Med 7:119-125.
Page R, Boolell M, Kalfas A, Sawyer S, Pestell R, Ward G, Alford F (1991) Insulin secretion, insulin sensitivity and glucose‐mediated glucose disposal in Cushing's disease: a minimal model analysis. Clin Endocrinol 35:509-517.
Walton C, Godsland IF, Proudler AJ, Felton CV, Wynn V (1992) Effect of body mass index and fat distribution on insulin sensitivity, secretion, and clearance in nonobese healthy men. J Clin Endocrinol Metab 75:170-175.
Godsland IF, Walton C, Felton C, Proudler A, Patel A, Wynn V (1992) Insulin resistance, secretion, and metabolism in users of oral contraceptives. J Clin Endocrinol Metab 74:64-70.
Martin BC, Warram JH, Krolewski AS, Bergman RN, Soeldner JS, Kahn CR (1992) Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25‐year follow‐up study. Lancet 340:925-929.
Bruce R, Godsland I, Stevenson J, Devenport M, Borth F, Crook D, Gathei M, Whitehead M, Wynn V (1992) Danazol induces resistance to both insulin and glucagon in young women. Clin Sci 82:211-217.
Martin BC, Warram JH, Rosner B, Rich SS, Soeldner JS, Krolewski AS (1992) Familial clustering of insulin sensitivity. Diabetes 41:850-854.
Godsland IF, Gangar K, Walton C, Cust MP, Whitehead MI, Wynn V, Stevenson JC (1993) Insulin resistance, secretion, and elimination in postmenopausal women receiving oral or transdermal hormone replacement therapy. Metabolism 42:846-853.
Walton C, Godsland IF, Proudler AJ, Wynn V, Stevenson JC (1993) The effects of the menopause on insulin sensitivity, secretion and elimination in non‐obese, healthy women. Eur J Clin Invset 23:466-473.
Letiexhe MR, Scheen AJ, Gérard PJ, Desaive C, Lefèbvre PJ (1994) Insulin secretion, clearance and action before and after gastroplasty in severely obese subjects. Int J Obesity 18:295-300.
Cook JS, Hoffman RP, Stene MA, Hansen JR (1993) Effects of maturational stage on insulin sensitivity during puberty. J Clin Endocrinol Metab 77:725-730.
Pacini G, Valerio A, Beccaro F, Nosadini R, Cobelli C, Crepaldi G (1988) Insulin sensitivity and beta‐cell responsivity are not decreased in elderly subjects with normal OGTT. J Am Geriatr Soc 36:317-323.
Haffner SM, Stern MP, Dunn J, Mobley M, Blackwell J, Bergman RN (1990) Diminished insulin sensitivity and increased insulin response in nonobese, nondiabetic Mexican Americans. Metabolism 39:842-847.
Osei K, Cottrell DA, Orabella MM (1991) Insulin sensitivity, glucose effectiveness, and body fat distribution pattern in nondiabetic offspring of patients with NIDDM. Diabetes Care 14:890-896.
Valdes CT, Elkind‐Hirsch KE (1991) Intravenous glucose tolerance test‐derived insulin sensitivity changes during the menstrual cycle. J Clin Endocrinol Metab 72:642-646.
Lovejoy J, Newby FD, Gebhart SSP, DiGirolamo M (1992) Insulin resistance in obesity is associated with elevated basal lactate levels and diminished lactate appearance following intravenous glucose and insulin. Metabolism 41:22-27.
Kahn SE, Bergman RN, Schwartz MW, Taborsky GJ, Porte D (1992) Short‐term hyperglycemia and hyperinsulinemia improve insulin action but do not alter glucose action in normal humans. Am J Physiol 262:E518.
Fukushima M, Nakai Y, Taniguchi A, Imura H, Nagata I, Tokuyama K (1993) Insulin sensitivity, insulin secretion and glucose effectiveness in anorexia nervosa: a minimal model analysis. Metabolism 42:1164-1168.
Kruszynska YT, Harry DS, Bergman RN, McIntyre N (1993) Insulin sensitivity, insulin secretion and glucose effectiveness in diabetic and non‐diabetic cirrhotic patients. Diabetologia 36:121-128.
Tokuyama K, Higaki Y, Fujitani J, Kiyonaga A, Tanaka H, Shindo M, Fukushima M, Nakai Y, Imura H, Nagata I, Taniguchi A (1993) Intravenous glucose tolerance test‐derived glucose effectiveness in physically trained humans. Am J Physiol 265:E298.
Allemann Y, Horber FF, Colombo M, Ferrari P, Shaw S, Jaeger P, Weidmann P (1993) Insulin sensitivity and body fat distribution in normotensive offspring of hypertensive parents. Lancet 341:327-331.
Abbate SL, Fujimoto WY, Brunzell JD, Kahn SE (1993) Effect of heparin on insulin‐glucose interactions measured by the minimal model technique: implications for reproducibility using this method. Metabolism 42:353-357.
Ferrari P, Alleman Y, Shaw S, Riesen W, Weidmann P (1991) Reproducibility of insulin sensitivity measured by the minimal model method. Diabetologia 34:527-530.
Scheen AJ, Letiexhe M, Gérard P, Castillo M, Lefèbvre PJ (1993) Insulin sensitivity estimated by the minimal model method in obese, normal, and anorectic women. Int J Obesity , Suppl; 17(2):96.
Steil GM, Buchanan TA, Murray J, Bergman RN (1993) Reproducibility of minimal model insulin sensitivity using full versus reduced sampling schedules (Abstract). Clin Res 41:68A.
Gautier JF, Scheen AJ, Jaminet C, Lefèbvre PJ (1991) SL 84.0418, a new potent alpha‐2 antagonist, increases insulin secretion after intravenous glucose in normal man. Diabetologia , Suppl; 34(2):A15.
Scheen AJ, Letiexhe M, Duysinx B, Paquot N, Lefèbvre PJ (1994) Estimation de la sensibilité à l'insuline par le “minimal model”: comparaison de différents protocoles d'hyperglycémie provoquée intraveineuse (Abstract). Diabète Metab , (Suppl); 20:3A.
Johnston C, Raghu P, McCulloch DK, Beard JC, Ward WK, Klaff LJ, KcKnight B, Bergman RN, Palmer JP (1987) Beta cell function and insulin sensitivity in non‐diabetic HLA identical siblings of insulin‐dependent diabetics. Diabetes 36:829-837.
Hramiak IM, Dupre J, Finegood DT (1993) Determinants of clinical remission in recent‐onset IDDM. Diabetes Care 16:125-132.
Taniguchi A, Nakai Y, Fukushima M, Kawamura H, Imura H, Nagata I, Tokuyama K (1992) Pathogenic factors responsible for glucose intolerance in patients with NIDDM. Diabetes 41:1540-1546.
Shennan NM, Godsland IF, Wynn V (1987) Derivation of a quantitative measure of insulin sensitivity from the intravenous tolbutamide test using the minimal model of glucose dynamics. Diabetologia 30:314-322.
Bonora E, Moghetti P, Zancanaro C, Cigolini M, Querena M, Cacciatori V, Corgnali A, Muggeo M (1989) Estimates of in vivo insulin action in man: comparison of insulin tolerance tests with euglycemic and hyperinsulinemic glucose clamps. J Clin Endocrinol Metab 68:374-378.
Akinmokun A, Selby PL, Ramaiya K, Alberti KGMM (1992) The short insulin tolerance test for determination of insulin sensitivity: a comparison with the euglycaemic clamp. Diabetic Med 9:432-437.
Grulet H, Durlach V, Hecart AC, Gross A, Leutenegger M (1993) Study of the rate of early glucose disappearance following insulin injection: insulin sensitivity index. Diabetes Res Clin Pract 20:201-207.
Hirst S, Phillips DIW, Vines SK, Clark PM, Hales CN (1993) Reproducibility of the short insulin tolerance test. Diabetic Med 10:839-842.
Dornhorst A, Edwards SGM, Nicholls JSD, Anyaoku V, McLaren D, Heslop KE, Elkeles RS, Beard RW, Johnston DG (1991) A defect in insulin release in women at risk of future non‐insulin‐dependent diabetes. Clin Sci 81:195-199.
Robinson S, Chan SP, Spacey S, Anyaoku V, Johnston DG, Franks S (1992) Postprandial thermogenesis is reduced in polycystic ovary syndrome and is associated with increased insulin resistance. Clin Endocrinol (Oxford) 36:537-543.
Galvin P, Ward G, Walters J, Pestell R, Koschmann M, Vaag Martin I, Best JD (1992) A simple method for quantitation of insulin sensitivity and insulin release from an intravenous glucose tolerance test. Diabetic Med 9:921-928.
Castillo M, Scheen AJ, Luyckx AS, Lefèbvre PJ (1985) A new test to simultaneously characterize the hepatic ability to increase blood glucose, the residual B‐cell function and the insulin sensitivity (Abstract). Diabetes Res Clin Pract , Suppl; 2(1):S90.
Castillo MJ, Scheen AJ, Lefèbvre PJ, A modified glucagon test allowing simultaneous estimation of insulin secretion and insulin sensitivity: application to obesity, IDDM and NIDDM. J Clin Endocrinol Metab, Submitted.; .
Scheen AJ, Castillo M, Salvatore T, Lefèbvre PJ (1989) Lack of deleterious effects of the alpha‐1 adrenoceptor blocking agent doxazosin on insulin secretion and insulin sensitivity in healthy men. Curr Ther Res 46:200-209.
Iles RA, Cohen RD (1987) NMR as a metabolic tool. Baillière's Clin Endocrinol Metab 1:937-966.
Jue T, Rothman DL, Tavitian BA, Shulman RG (1989) Natural‐abundance 13C‐NMR study of glycogen repletion in human liver and muscle. Proc Natl Acad Sci USA 86:1439-1442.
Shulman GI, Rothman DL, Smith D, Johnson CM, Blair JB, Shulman RG, DeFronzo RA (1985) Mechanism of liver glycogen repletion in vivo by nuclear magnetic resonance spectroscopy. J Clin Invest 76:1229-1236.
Jue T, Rothman DL, Shulman GI, Travitian BA, DeFronzo RA, Shulman RG (1989) Direct observation of glycogen synthesis in human muscle with 13C NMR. Proc Natl Acad Sci USA 86:4489-4491.
Shulman GI, Rothman DL, Jue T, Stein P, DeFronzo RA, Shulman RG (1990) Quantitation of muscle glycogen synthesis in normal subjects and subjects with non‐insulin‐dependent diabetes by 13C nuclear magnetic resonance spectroscopy. N Engl J Med 322:223-228.
Phelps ME, Mazziotta JC, Schelbert HR Positron Emission Tomography and Autoradiography: Principles and Applications for the Brain and Heart, Raven Press, New York; 1986.
Nuutila P, Koivisto VA, Knuuti J, Ruotsalainen U, Teräs M, Haaparanta M, Bergman J, Solin O, Voipio‐Pulkki L‐M, Wegelius U, Yki‐Järvinen H (1992) Glucose‐free fatty acid cycle operates in human heart and skeletal muscle in vivo. J Clin Invest 89:1767-1774.
Nuutila P, Knuuti J, Ruotsalainen U, Koivisto VA, Eronen E, Teräs M, Bergman J, Haaparanta M, Voipio‐Pulkki L‐M, Viikari J, Rönnemaa T, Wegelius U, Yki‐Järvinen H (1993) Insulin resistance is localized to skeletal but not heart muscle in type 1 diabetes. Am J Physiol 264:E756.