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Poster (Scientific congresses and symposiums)
Linearity and stationarity of the pharmacokinetics of tiludronate in horses
Delguste, Catherine; Doucet, Michèle; Amory, Hélène et al.
2005AAVPT 14 Biennal Symposium
 

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Keywords :
pharmacology; bisphosphonates; horses
Abstract :
[en] Two studies were conducted in order to assess the linearity and stationarity of the pharmacokinetics of tiludronate in horses. For each study, plasma concentrations of tiludronate were measured by HPLC-UV at regular intervals and noncompartmental analysis was performed. First, single intravenous administrations of 0.05 (group 1, n = 5), 0.1 (group 2, n = 5) and 0.2 mg/kg (group 3, n = 5) were performed in healthy male adult horses. A linear relationship between groups was found for C5min (C5min = 0.0726 + 11.8589 * dose) as well as for AUC0-inf (AUC0-inf = -0.632561 + 30.9649 * dose). Clearance ranged from 0.033 to 0.044 L/h/kg and was not significantly different between groups. MRT (h) were 3.96, 4.95 and 9.40 and VDss (L/kg) were 0.16, 0.19 and 0.28 for the 0.05, 0.1 and 0.2 mg/kg doses respectively. Second, 10 daily intravenous administrations at a dosage rate of 0.1 mg/kg were administered to 4 healthy horses. Plasma tiludronate concentrations were measured after the 1st and 10th dose as well as 8 hours after each dose. The mean plasma accumulation ratio between the 1st and the 10th dose was 1.31 ± 0.48. Medians of the tiludronate concentration values measured in plasma 8 hours post-dose were not statistically different between doses. Maximum and minimum concentrations of tiludronate (mg/L) following the last dose were 0.91 and 0.04 respectively. It was concluded that the pharmacokinetics of tiludronate in horses are linear from 0.05 to 0.2 mg/kg IV and stationary after 10 IV administrations of 0.1 mg/kg.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Delguste, Catherine ;  Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Département clinique des animaux de compagnie et des équidés
Doucet, Michèle;  Université de Montréal - UdeM > Biomédecine
Amory, Hélène ;  Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Médecine interne des équidés
Guyonnet, Jérôme;  CEVA Santé Animale
Thibaud, Dominique;  CEVA Santé Animale
Language :
English
Title :
Linearity and stationarity of the pharmacokinetics of tiludronate in horses
Publication date :
2005
Event name :
AAVPT 14 Biennal Symposium
Event organizer :
AAVPT
Event date :
mai 2005
Audience :
International
Funders :
Ceva Santé Animale [FR]
Available on ORBi :
since 20 June 2011

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