[en] Anti-laminin antibodies were sought for in the serum of workers exposed to mercury vapour (Hg, n = 58), lead (Pb, n = 38) or cadmium (Cd, n = 47). Thirty-one workers removed from Cd exposure for an average of eight years were also examined. Compared with control workers matched for age and socio-economic status, the prevalence of circulating anti-laminin antibodies was not increased in workers exposed to Hg (mean duration of exposure: 7.9 years and mean urinary excretion of Hg: 72 micrograms/g creatinine) nor in those exposed to Pb (mean duration of exposure: 10.6 years and mean Pb levels in blood: 535 micrograms/l). In contrast, anti-laminin antibodies were significantly more prevalent in Cd-exposed workers whose urinary Cd exceeded 20 micrograms/g creatinine. This observation was made in both currently exposed workers and in workers removed from Cd exposure (mean duration of exposure: 9.4 and 24.6 years and mean urinary Cd: 7.8 and 13.4 micrograms/g creatinine respectively). These autoantibodies were found in Cd workers with normal renal function as well as in those with increased proteinuria.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Bernard, A. M.
Roels, H. R.
Foidart, Jean-Michel ; Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique
Lauwerys, R. L.
Language :
English
Title :
Search for anti-laminin antibodies in the serum of workers exposed to cadmium, mercury vapour or lead.
Publication date :
1987
Journal title :
International Archives of Occupational and Environmental Health
ISSN :
0340-0131
eISSN :
1432-1246
Publisher :
Springer Science & Business Media B.V., New York, United States - New York
Bernard A., Roels H., Hubermont G., Buchet J.P., Masson P.L., Lauwerys R.R. (1976) Characterization of the proteinuria in cadmium-exposed workers. Int Arch Occup Environ Health 38:19-30.
Bernard A., Lauwerys R. (1983) Continuous flow system for automation of latex immunoassay by particle counting. Clin Chem 29:1007-1011.
Bernard A., Lauwerys R., Gengoux P., Mahieu P., Foidart J.M., Druet P., Weening J.J. (1984) Anti-laminin and anti-type IV procollagen antibodies in Sprague-Dawley and Brown-Norway rats chronically exposed to cadmium. Toxicology 31:307-313.
Bernard A., Mahieu P., Foidart J.M., Lauwerys R. (1986) Anti-basement membrane antibodies in the serum of healthy subjects. N Engl J Med 314:1456-1457.
Bernard A., Foidart J.M., Mahieu P., Viau C., Lauwerys R. (1986) Detection of anti-laminin antibodies in sera by latex agglutination test. Clin Chem 32:1468-1472.
Druet P., Bernard A., Hirsch F., Weening J.J., Gengoux P., Mahieu P., Birkeland S. (1982) Immunologically mediated glomerulonephritis induced by heavy metals. Arch Toxicol 50:187-194.
Henry R.J. Clinical chemistry. Principles and technics, Harper and Row, New York; 1965.
Lauwerys R., Bernard A., Roels H., Buchet J.P., Gennart J.P., Mahieu P., Foidart J.M. (1983) Anti-laminin antibodies in workers exposed to mercury vapour. Toxicol Lett 17:113-116.
Lauwerys R. Industrial chemical exposure: guidelines for biological monitoring, Biomedical Publications, Davis, California; 1983.
Lawrence D.A. (1985) Immunotoxicity of heavy metals. Immunotoxicology and immunopharmacology , J.H., Dean, A., Munson, M., Luster, H., Amos, Raven Press, New York; 341-353.
Roels H.A., Buchet J.P., Lauwerys R., Bruaux P., Claeys-Thoreau F., Lafontaine A., Van Overschelde J., Verduyn G. (1978) Lead and cadmium absorption among children near a non-ferrous metal plant. A follow-up study of a test case. Environ Res 15:290-308.
Stonard M.D., Chater B.V., Duffield D.P., Sullivan J.J., Lockwood M. (1983) Circulating immune complexes in individuals occupationally exposed to mercury vapour. Chemical toxicology and clinical chemistry of metals , S.S., Brown, J., Savory, Proc 2nd Int Conf in Montreal, Academic Press, London; 135-138.
Wedeen R.P., Mallick D.K., Batuman V. (1979) Detection and treatment of occupational lead nephropathy. Arch Int Med 139:53-57.
