[en] A 46,XX;47,XX,+9;47,XX,+?mar karyotype was detected in an amniotic fluid cell culture and confirmed in a subsequent fetal blood sample from a 40-year-old woman. After termination of the pregnancy, none of the 186 mitoses obtained from a second blood sample was trisomic for chromosome 9 (p less than 0.001). Selection against cells containing trisomy 9 is postulated to explain the disappearance of the lymphocyte clone.
Disciplines :
Genetics & genetic processes
Author, co-author :
Herens, Christian ; Centre Hospitalier Universitaire de Liège - CHU > PLAN COS
Pierquin, Geneviève ; Centre Hospitalier Universitaire de Liège - CHU > Génétique
Verloes, Alain ; Université de Liège - ULiège > Génétique générale et humaine
Schaaps, Jean-Pierre ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Embryologie
Frederic, J.
Language :
English
Title :
Mosaicism of 46,Xx/47,Xx,+9/47,Xx,+?Mar in the Same Amniotic Fluid with Apparent Loss of One Cell Line after Delivery
Publication date :
May 1989
Journal title :
Prenatal Diagnosis
ISSN :
0197-3851
eISSN :
1097-0223
Publisher :
John Wiley & Sons, Hoboken, United States - New Jersey
Buckton K.E., Spowart G., Newton M.S., Evans H.J. (1985) Forty four probands with an additional ‘marker’ chromosome. Hum. Genet. 69:353-370.
Francke U., Benirschke K., Jones O.W. (1975) Prenatal diagnosis of trisomy 9. Hum. Genet. 29:243-250.
Greenberg F., Elsas N.T., Reidy J.A., Chen A.T.L., Stone L.B. (1982) Autosomal mosaicism in amniotic fluid cells from a twin pregnancy. Am. J. Med. Genet. 11:109-112.
Hassold T. (1985) The origin of aneuploidy in humans. Aneuploidy: Etiology and Mechanisms , Vaughn‐Dellarco, V., Voytek, P., Hollaender, A. A., (Eds)., New York, Plenum Press; 103-116.
Hsu L.Y.F., Perlis T.E. (1984) United States survey on chromosome mosaicism and pseudomosaicism in prenatal diagnosis. Prenat. Diagn. 4:97-130.
Mohandas T., Canning N., Chu W., Passage M.B., Anderson C.E., Kaback N.M. (1985) Marker chromosomes: cytogenetic characterization and implications for prenatal diagnosis. Am. J. Med. Genet. 20:361-368.
Pfeiffer R.A., Ulmer R., Kniewald A., Wagner‐Theissen E. (1984) Prenatal diagnosis of trisomy 9 mosaicism possibly limited to fetal membranes. Prenat. Diagn. 4:387-389.
Sachs E.S., van Hemel J.O., Den Hollander J.C., Jahoda M.G.J. (1987) Marker chromosomes in a series of 10000 prenatal diagnoses. Cytogenetic and follow‐up studies. Prenat. Diagn. 7:81-89.
Sutherland G.R., Carter R.F., Morris L.L. (1976) Partial and complete trisomy 9: delineation of a trisomy 9 syndrome. Hum. Genet. 32:133-140.
Warburton D., Kwame A.‐Y., Francke U. (1987) Four new cases, and confirmation of the chromosomal origin of the supernumerary chromosome in one of the original Pallistermosaic syndrome cases. Am. J. Med. Genet. 27:275-283.
Wisniewski L.P., Doherty R.A. (1985) Supernumerary microchromosomes identified as inverted duplications of chromosome 15: a report of three cases. Hum. Genet. 69:161-163.
Wisniewski L.P., Hassold T., Heffelfinger J., Higgins J.V. (1979) Cytogenetic and clinical studies in five cases of inv dup (15). Hum. Genet. 50:259-270.
Zadeh T.M., Peters J., Sandlin C. (1987) Prenatal diagnosis of mosaic trisomy 9. Prenat. Diagn. 7:67-70.
