[en] Mercuric chloride induces in the Brown-Norway rat a biphasic autoimmune disease characterized initially by linear IgG deposits along the glomerular basement membrane followed later by granular IgG deposition. In the present study, anti-glomerular basement membrane antibodies and immune complex-like material were sequentially assessed in serial serum samples. Both were transiently found at the same period. Glomerular linear IgG deposits were present on day 11 but circulating anti-glomerular basement membrane antibodies were only found later on day 16. Circulating immune complexes were first detectable on day 8 before the earliest granular IgG deposits were first observed in the spleen vessels on day 16. The disappearance of circulating anti-glomerular basement membrane antibodies and of circulating immune complexes, although HgCl2 injections were pursued, is in agreement with the self-limited character of mercuric chloride induced autoimmune disease and suggests the induction of immunosuppressive mechanisms.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Bellon, B.
Capron, M.
Druet, E.
Verroust, P.
Vial, M. C.
Sapin, C. C.
Girard, J. F.
Foidart, Jean-Michel ; Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique - Labo de biologie des tumeurs et du développement
Mahieu, P.
Druet, P.
Language :
English
Title :
Mercuric chloride induced autoimmune disease in Brown-Norway rats: sequential search for anti-basement membrane antibodies and circulating immune complexes.
Sapin C., Druet E., Druet P. (1977) Induction of anti‐glomerular basement membrane antibodies in the Brown‐Norway rat by mercuric chloride. Clin Exp Immunol 28:173-179.
Druet P., Druet E., Potdevin F., Sapin C. (1978) Immune type glomerulonephritis induced by HgCl2 in the Brown‐Norway rat. Ann Immunol (Institut Pasteur) 129 C:777-792.
Bernaudin JF, Druet E., Belair MF, Pinchon MC, Sapin C., Druet P. (1979) Extrarenal immune complex type deposits induced by mercuric chloride in the Brown‐Norway rat. Clin Exp Immunol 38:265-273.
Roman‐Franco AA, Turiello M., Albini B., Ossi E., Milgrom F., Andres GA. (1978) Anti‐basement membrane antibodies and antigen‐antibody complexes in rabbits injected with mercuric chloride. Clinical Immunology and Immunopathology 9:464-481.
Foidart JM, Berman JJ, Paglia L., Rennard S., Abe S., Perantoni A., Martin GR. (1980) Synthesis of fibronectin, laminin and several collagens by a liver‐derived epithelial line. Lab Invest 42:525-532.
Bellon B., Sapin C., Druet P. (1975) Comparaison de la sensibilité des techniques d'immunofluorescence et d'immunoperoxydase en méthodes directe et indirecte. Ann Immunol (Institut Pasteur) 126 C:15-22.
Mahieu P., Lambert PH, Miescher PA. (1974) Detection of anti‐glomerular basement membrane antibodies by a radio immunological technique. Clinical application in human nephropathies. J Clin Invest 54:128-137.
Druet E., Mahieu P., Foidart JM, Druet P., Magnetic solid phase enzyme immuno‐assay for the detection of anti‐glomerular basement membrane antibodies. J Immunol Methods; 1982.
Guesdon JL, Avrameas S. (1977) Magnetic solid phase enzyme‐immuno‐assay. Immunochemistry 14:443-447.
Avrameas S. (1969) Coupling of proteins with glutaraldehyde. Immunochemistry 6:43-52.
Porter R.R. (1969) The hydrolysis of rabbit gammaglobulin and antibodies with crystalline papain. Biochem J 73:119-126.
Druet P., Bariéty J., Laliberté F., Bellon B., Belair MF, Paing M. (1978) Distribution of heterologous anti‐peroxidase antibodies and their fragments in the superficial renal cortex of normal Wistar‐Munich rat. An ultrastructural study. Lab Invest 39:623-631.
Foidart JM, Bere EW, Yaar M., Rennard SI, Gullino M., Martin GR, Katz SI. (1980) Distribution and immuno‐electron microscopic localization of laminin, a non collagenous basement membrane glycoprotein. Lab Invest 42:336-342.
Theophilopoulos AN, Wilson CB, Dixon FJ. (1976) The Raji cell radio‐immune assay for detecting immune complexes in human sera. J Clin Invest 57:169-182.
Zanetti M., Bellon B., Verroust P., Druet P. (1980) A search for circulating immune complex‐like material during the course of auto‐immune complex glomerulonephritis in Lewis and Brown‐Norway rats. Clin Exp Immunol 42:86-94.
Nydegger UE, Lambert PH, Gerber H., Miescher PA. (1974) Circulating immune complexes in the serum in systemic lupus erythematosus (SLE) and in carriers of hepatitis B antigen: quantitation by binding to radio‐labelled Clq. J Clin Invest 54:297-309.
Mayer MM. (1961) Complement and complement fixation. Experimental immunochemistry , Kabat EA, Mayer MM,. Springfield(III):, Thomas; 133-240.
Capron M., Ayed K., Druet E., Sapin C., Mandet C., Druet P., Girard JF. (1980) Complement studies in BN rats with mercuric chloride induced immune glomerulonephritis. Ann Immunol (Institut Pasteur) 131 D:43-55.
Stenman S., Vaheri A. (1978) Distribution of a major connective tissue protein, fibronectin, in normal human tissues. J Exp Med 147:1054-1064.
Scheinman JI, Foidart JM, Michael AF. (1980) The immunohistology of glomerular antigens. V. The collagenous antigens of the glomerulus. Lab Invest 43:373-381.
Foidart JB, Pirard Y., Foidart JM, Dubois CH, Mahieu P. (1980) Anti‐type IV procollagen and anti‐laminin antibodies in Good‐pasture's syndrome. (Abstract.). Kidney Int 18:136.
Colten HR. (1977) Complement synthesis. Biological amplification systems in immunology , Day NK, Good RA,. New York:, Plenum Medical Book Company; 45-67.
Hinglais N., Druet P., Grossetête J., Sapin C., Bariéty J. (1979) Ultrastructural study of nephritis induced in Brown‐Norway rats by mercuric chloride. Lab Invest 41:150-159.
Michaud A., Sapin C., Aiach M., Druet P., Clotting abnormalities during the course of immune type glomerulonephritis induced by HgCl2 in the Brown‐Norway rat. European Society of Clinical Investigation. 14th Annual Meeting, Salzburg.; 1980, 25.
Theophilopoulos AN, Dixon FJ. (1979) The biology and detection of immune complexes. Advances in immunology , Dixon FJ, Kunkel HG.,. New York ;, Academic Press; 28:89-220.
Notkins AL, Mahar S., Sheele C., Goffman J. (1966) Infectious virus‐antibody complex in the blood of chronically infected mice. J Exp Med 124:81-97.
Oldstone MBA, Dixon FJ. (1970) Persistent lymphotic choriomeningitis viral infection. III. Virus‐anti‐viral antibody complexes and associated chronic disease following transplacental infection. J Immunol 105:829-837.
Andrews BS, Eisenberg RA, Theofilopoulos AN, Izui S., Wilson CB, McConahey PJ, Murphy ED, Roths JB, Dixon FJ. (1978) Spontaneous murine lupus like‐syndromes. Clinical and immunopathological manifestations in several strains. J Exp Med 148:1198-1215.
June CH, Contreras CE, Perrin LH, Lambert PH, Miescher PA. (1979) Circulating and tissue‐bound immune complex formation in murine malaria. J Immunol 122:2154-2166.
Ronco P., Woodrow D., Riviere V., Moss J., Verroust P., Guillon JC, Gresser I., Sloper JC, Morel‐Maroger L. (1980) Further studies of the inhibition of lymphocyte chorio‐meningitis‐induced glomerulonephritis by anti‐interferon globulin. Circulating immune complexes and ultrastructural studies. Lab Invest 43:37-46.
Cochrane CG, Koffler D. (1973) Immune complex disease in experimental animals and man. Advances in Immunology, 16 , Dixon FJ, Kunkel HG,. New York:, Academic Press; 185-264.
Weening JJ, Hoedemaeker PH, Bakker WW. (1981) Immunoregulation and antinuclear antibodies in mercury‐induced glomerulopathy in the rat. Clin Exp Immunol 45:64-71.
Hirsch F., Coudere J., Sapin C., Fournié, Polyclonal effect of HgCl2 in the rat. Its possible role in mercury induced glomerulonephritis. VIIIth International Congress of Nephrology, Athens,. Abstracts, p.; 1981, 138.
