Reference : Hyperplasia of rat arteries smooth muscle cells associated with development and rever...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/83380
Hyperplasia of rat arteries smooth muscle cells associated with development and reversal of renal hypertension.
English
Rorive, G. L. [ > > ]
Carlier, P. J. [ > > ]
Foidart, Jean-Michel mailto [Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique - Labo de biologie des tumeurs et du développement >]
1980
Clinical Science
Blackwell Publishing
59
suppl 6
335s-338s
Yes (verified by ORBi)
International
0009-9287
Oxford
United Kingdom
[en] 1. Renal hypertension produces a marked and rapidly detectable hypertrophy of the rat aorta, due to smooth muscle cell hyperplasia and connective tissue deposition. 2. As we described previously for collagen synthesis, cell hyperplasia is a very early event which reaches a maximum at a time when the blood pressure is far from its highest level, and thereafter progressively decreases. 3. Reserpine prevents the vascular wall changes on the arterial as well as the venous side of the circulation. On the other hand, captopril although effective in preventing the blood pressure rise does not suppress the hyperplastic response. 4. The arterial hypertensive disease appears to be reversible, when renal ischaemia is corrected. The smooth muscle cell hyperplasia is, however, only partly and slowly reversible. 5. These data suggest that blood pressure is not the only determinant of the vascular wall response, and that the effect of a drug on the blood pressure does nt necessarily predict the vascular wall response.
http://hdl.handle.net/2268/83380

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